| UniProt/SwissProt ID: | NID1_HUMAN |
| Description: | nidogen 1 [Source:HGNC Symbol;Acc:7821] |
| Location: | chr1 q42.3 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T114 | ADLDTtDGLGK | PhosphoSitePlus | |
| T113 | LADLDtTDGLG | PhosphoSitePlus | |
| T100 | GLFPPtFGAVA | PhosphoSitePlus | |
| S327 | GADTYsVPSVL | PhosphoSitePlus | |
| T1193 | QPHKQtRLYGI | PhosphoSitePlus | |
| T1098 | SYMDGtNRRIL | Ldl_recept_b | PhosphoSitePlus |
| T517 | TGGEFtRQAEV | G2F | PhosphoSitePlus |
| T1184 | AISKEtDAFQP | PhosphoSitePlus | |
| Y326 | GGADTySVPSV | PhosphoSitePlus | |
| T909 | REVEGtRTRPG | Thyroglobulin_1 | PhosphoSitePlus |
| Dephosphorylation site |
| NID1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000264187 | V875I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264187 | F1036S | HPI | Colorectal Cancer | 16959974 | ENSP00000264187 | V449G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355554 | V449G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355554 | V742I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000264187 | Q172* | COSMIC | Skin Cancer | 21984974 | ENSP00000264187 | F1036S | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264187 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3.7 | 18715028 | ENSP00000264187 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.67 | 20739354 | ENSP00000264187 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.67 | 20739354 |
| Hyperphosphorylation site |
| NID1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NID1_HUMAN | PTPRF_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| NID1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0010811 | positive regulation of cell-substrate adhesion | IEA | biological_process |
| GO:0007160 | cell-matrix adhesion | IEA | biological_process |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0071944 | cell periphery | IEA | cellular_component |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0032836 | glomerular basement membrane development | IEA | biological_process |
| GO:0005605 | basal lamina | IEA | cellular_component |
| GO:0050840 | extracellular matrix binding | IEA | molecular_function |
| GO:0030198 | extracellular matrix organization | IEA | biological_process |
| GO:0005518 | collagen binding | IEA | molecular_function |
| GO:0043237 | laminin-1 binding | IEA | molecular_function |