Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTC1_HUMAN
Description:patched 1 [Source:HGNC Symbol;Acc:9585]
Location:chr9 q22.32
Node attribute:PPI(target); receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y873IMPNNyKNGSDPatchedPhosphoSitePlus
S435ILKSFsDVSVIPatchedPhosphoSitePlus
S463LRWDCsKSQGAPatchedPhosphoSitePlus
S1331STEGHsGPSNRPhosphoSitePlus
Y884DGVLAyKLLVQPatchedPhosphoSitePlus

Dephosphorylation site
PTC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000332353A1101SCOSMICOvarian Cancer21720365
ENSP00000332353E835*COSMICCentral Nervous System Neoplasms9192811
ENSP00000332353E667ACOSMICIntestines Cancer9192811
ENSP00000332353R1442WCOSMICSkin Cancer21984974
ENSP00000332353Q160*COSMICSkin Cancer18854826
ENSP00000332353S683FCOSMICSkin Cancer19726763
ENSP00000332353T678ICOSMICSkin Cancer12007715
ENSP00000332353T362ICOSMICSkin Cancer12007715
ENSP00000332353P725SCOSMICCentral Nervous System Neoplasms9205058
ENSP00000332353Y788*COSMICSkin Cancer15656799
ENSP00000332353S480*COSMICSkin Cancer17597822
ENSP00000332353Q242fs*8COSMICCentral Nervous System Neoplasms18769486
ENSP00000332353L923PCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353R995SCOSMICSkin Cancer15656799
ENSP00000332353A1380VCOSMICSkin Cancer18854826
ENSP00000332353H328fs*14COSMICOther Cancer18502968
ENSP00000332353A563VCOSMICSkin Cancer17597822
ENSP00000332353Q938*COSMICSkin Cancer19726763
ENSP00000332353Y452*COSMICSkin Cancer18854826
ENSP00000332353E992GCOSMICBreast Cancer9192811
ENSP00000332353Q576*COSMICSkin Cancer21102684
ENSP00000332353R1308GDing2008, COSMICLung Cancer18948947
ENSP00000332353P641LCOSMICSkin Cancer10656695
ENSP00000332353S707FCOSMICSkin Cancer10656695
ENSP00000332353Q688KDing2008, COSMICLung Cancer18948947
ENSP00000332353F826fs*4COSMICSkin Cancer18854826
ENSP00000332353E149*COSMICSkin Cancer17597822
ENSP00000332353R665GCOSMICSkin Cancer8782823
ENSP00000332353S716fs*30COSMICSkin Cancer15656799
ENSP00000332353G1167WCOSMICSkin Cancer16204023
ENSP00000332353L175FCOSMICSkin Cancer8658145
ENSP00000332353Q905*COSMICSkin Cancer18854826
ENSP00000332353E684*COSMICSkin Cancer18854826
ENSP00000332353D879NCOSMICBreast Cancer20668451
ENSP00000332353T230ICOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353S331FCOSMICSkin Cancer15656799
ENSP00000332353P1302HCOSMICOther Cancer15308259
ENSP00000332353H944RCOSMICHead and Neck Cancer21798897
ENSP00000332353A1101SCOSMICOvarian Cancer21720365
ENSP00000332353V988ECOSMICOvarian Cancer21720365
ENSP00000332353W1018*COSMICSkin Cancer11159175
ENSP00000332353S1197FCOSMICSkin Cancer15656799
ENSP00000332353W1051*COSMICSkin Cancer17597822
ENSP00000332353S494FCOSMICSkin Cancer17597822
ENSP00000332353W863*COSMICSkin Cancer19726763
ENSP00000332353K100TBIOMARTBreast Cancer21930507, 21930502
ENSP00000332353C1365*COSMICOvarian Cancer21720365
ENSP00000389744K34TBIOMARTBreast Cancer21930507, 21930502
ENSP00000332353M319VCOSMICIntestines Cancer21234763
ENSP00000332353L923PCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353V763fs*9COSMICSkin Cancer15656799
ENSP00000332353E970fs*25COSMICSkin Cancer18854826
ENSP00000332353T1214fs*41COSMICOther Cancer15308259
ENSP00000332353F585fs*38COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353Q816*COSMICSkin Cancer18854826
ENSP00000332353I791TCOSMICSkin Cancer17597822
ENSP00000332353T691ICOSMICSkin Cancer12007715
ENSP00000332353P1202LCOSMICSkin Cancer10220428
ENSP00000332353P155SCOSMICSkin Cancer8782823
ENSP00000332353Q365*COSMICSkin Cancer10874304
ENSP00000332353R135*COSMICOther Cancer18502968
ENSP00000332353S1326fs*46COSMICLung Cancer18948947
ENSP00000332353G1212SCOSMICSkin Cancer15656799
ENSP00000332353Q1366KCOSMICOvarian Cancer21720365
ENSP00000332353E989*COSMICSkin Cancer8782823
ENSP00000332353Q466ECOSMICOvarian Cancer21720365
ENSP00000332353H671YCOSMICSkin Cancer10656695
ENSP00000332353D879fs*24COSMICOther Cancer18502968
ENSP00000332353M457fs*34COSMICOther Cancer15308259
ENSP00000332353Q184*COSMICSkin Cancer10656695
ENSP00000332353V1084fs*3COSMICSkin Cancer10220428
ENSP00000332353Q694*COSMICCentral Nervous System Neoplasms10874314
ENSP00000332353P1198SCOSMICSkin Cancer19726763
ENSP00000332353R1114WHPINeoplasms by Histologic Type9620294
ENSP00000332353E1242KHPINeoplasms by Histologic Type11286632
ENSP00000332353H944RCOSMICHead and Neck Cancer21798897
ENSP00000332353Q466*COSMICSkin Cancer16204023
ENSP00000332353Q361*COSMICEsophageal Cancer9523206
ENSP00000332353S410NCOSMICSkin Cancer12007715
ENSP00000332353G484RCOSMICSkin Cancer19287961
ENSP00000332353Y222*COSMICSkin Cancer10874304
ENSP00000332353W926CCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353Q688*COSMICSkin Cancer11159175
ENSP00000332353S616NCOSMICSkin Cancer11159175
ENSP00000332353R441HCOSMICBreast Cancer20668451
ENSP00000332353L341FDing2008, COSMICLung Cancer18948947
ENSP00000332353W926CCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353W256*COSMICSkin Cancer8782823
ENSP00000332353Q466ECOSMICOvarian Cancer21720365
ENSP00000332353T1195SCOSMICSkin Cancer9205058
ENSP00000332353F585fs*38COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353G774ECOSMICSkin Cancer15656799
ENSP00000332353C327*COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353A736VCOSMICSkin Cancer10656695
ENSP00000332353E539*COSMICSkin Cancer17597822
ENSP00000332353W926*COSMICSkin Cancer15656799
ENSP00000332353E680*COSMICSkin Cancer18854826
ENSP00000332353V1164ICOSMICCentral Nervous System Neoplasms9233770
ENSP00000332353E127fs*10COSMICSkin Cancer15656799
ENSP00000332353P1306SCOSMICSkin Cancer10874304
ENSP00000332353T959fs*3COSMICSkin Cancer15656799
ENSP00000332353P1196SCOSMICSkin Cancer8782823
ENSP00000332353M1139ICOSMICCentral Nervous System Neoplasms9233770
ENSP00000332353W129*COSMICSkin Cancer18854826
ENSP00000332353R1394*COSMICCentral Nervous System Neoplasms18772890
ENSP00000332353A451fs*5COSMICCentral Nervous System Neoplasms21325292
ENSP00000332353E165*COSMICSkin Cancer18854826
ENSP00000332353G1163SCOSMICSkin Cancer11159175
ENSP00000332353L1016FCOSMICSkin Cancer17597822
ENSP00000332353G1093*COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353V829MHPINeoplasms by Histologic Type11286632
ENSP00000332353V188fs*32COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353Y955HCOSMICBreast Cancer9192811
ENSP00000332353V988ECOSMICOvarian Cancer21720365
ENSP00000332353G1396RCOSMICSkin Cancer17597822
ENSP00000332353N349fs*18COSMICSkin Cancer15656799
ENSP00000332353V474ICOSMICOvarian Cancer21720365
ENSP00000332353Q1284HCOSMICOther Cancer15308259
ENSP00000332353C327*COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353P702LCOSMICSkin Cancer10220428
ENSP00000332353P670SCOSMICSkin Cancer10220428
ENSP00000332353T416SCOSMICOther Cancer18502968
ENSP00000332353S1292FCOSMICOther Cancer15308259
ENSP00000332353E237KCOSMICHead and Neck Cancer11159175
ENSP00000332353V829MCOSMICSkin Cancer21184537
ENSP00000332353P644SCOSMICSkin Cancer19726763
ENSP00000332353A478VCOSMICSkin Cancer12007715
ENSP00000332353W399*COSMICSkin Cancer16204023
ENSP00000332353E1066*COSMICHead and Neck Cancer11159175
ENSP00000332353R962TCOSMICSkin Cancer21699520
ENSP00000332353W278*COSMICSkin Cancer18854826
ENSP00000332353W387*COSMICSkin Cancer10874304
ENSP00000332353P689LCOSMICSkin Cancer19726763
ENSP00000332353R195MCOSMICSkin Cancer21102684
ENSP00000332353G1093*COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353R602*COSMICCentral Nervous System Neoplasms10564585
ENSP00000332353F743LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000332353W844CCOSMICCentral Nervous System Neoplasms19726761
ENSP00000332353P252SCOSMICSkin Cancer12007715
ENSP00000332353V442fs*14COSMICSkin Cancer18854826
ENSP00000332353R770*COSMICSkin Cancer11159175
ENSP00000332353M561RCOSMICHead and Neck Cancer11573822
ENSP00000332353E1242KCOSMICSkin Cancer21184537
ENSP00000332353R441HCOSMICBreast Cancer20668451
ENSP00000332353W236*COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353V1034LCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353G545ECOSMICSkin Cancer18854826
ENSP00000332353V763ICOSMICSkin Cancer10656695
ENSP00000332353R682LDing2008, COSMICLung Cancer18948947
ENSP00000332353Q242*COSMICSkin Cancer18854826
ENSP00000332353V188fs*32COSMICCentral Nervous System Neoplasms21163964
ENSP00000332353V474ICOSMICOvarian Cancer21720365
ENSP00000332353G288DCOSMICSkin Cancer10656695
ENSP00000332353N814fs*16COSMICSkin Cancer18854826
ENSP00000332353P681LCOSMICSkin Cancer10874304
ENSP00000332353P504QCOSMICSkin Cancer16204023
ENSP00000332353Y955*COSMICSkin Cancer18854826
ENSP00000332353S1079ICOSMICSkin Cancer15656799
ENSP00000332353G238ECOSMICSkin Cancer19726763
ENSP00000332353L431QCOSMICSkin Cancer11159175
ENSP00000332353Y630fs*63COSMICSkin Cancer9620294
ENSP00000332353V994fs*1COSMICCentral Nervous System Neoplasms9041183
ENSP00000332353D898GCOSMICSkin Cancer18854826
ENSP00000332353K96*COSMICSkin Cancer17597822
ENSP00000332353Q417*COSMICSkin Cancer11159175
ENSP00000332353G854*COSMICHead and Neck Cancer15656799
ENSP00000332353A1243GCOSMICOther Cancer15308259
ENSP00000332353V439ACOSMICSkin Cancer12007715
ENSP00000332353Q361PCOSMICSkin Cancer10220428
ENSP00000332353T1214MCOSMICSkin Cancer12007715
ENSP00000332353I159LCOSMICSkin Cancer17597822
ENSP00000332353R1114WCOSMICSkin Cancer9620294
ENSP00000332353P568LCOSMICSkin Cancer19726763
ENSP00000332353D1305YCOSMICOther Cancer16931872
ENSP00000332353D879NCOSMICBreast Cancer20668451
ENSP00000332353Q338*COSMICOther Cancer19362041
ENSP00000332353V1034LCOSMICCentral Nervous System Neoplasms21163964
ENSP00000332353Q816LCOSMICEsophageal Cancer9523206

Differential expressed protein
PTC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SHH_HUMANPTC1_HUMANligand -> receptorHPMR
IHH_HUMANPTC1_HUMANligand -> receptorHPMR
SMO_HUMANPTC1_HUMANotherKEGG
IHH_HUMANPTC1_HUMANotherKEGG
GLI1_HUMANPTC1_HUMANTF -> target geneKEGG
GLI1_HUMANPTC1_HUMANTF -> target geneTRANSFAC
SP1_HUMANPTC1_HUMANTF -> target geneTRANSFAC
GLI3_HUMANPTC1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa04340Hedgehog signaling pathway
hsa05217Basal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008589regulation of smoothened signaling pathwayIEAbiological_process
GO:0003007heart morphogenesisIEAbiological_process
GO:0060603mammary gland duct morphogenesisIEAbiological_process
GO:0072661protein targeting to plasma membraneIDAbiological_process
GO:0009953dorsal/ventral pattern formationISSbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIMPbiological_process
GO:0061005cell differentiation involved in kidney developmenIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0010875positive regulation of cholesterol effluxIDAbiological_process
GO:0071397cellular response to cholesterolIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0043616keratinocyte proliferationIEAbiological_process
GO:0097108hedgehog family protein bindingIPImolecular_function
GO:0040008regulation of growthIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0007346regulation of mitotic cell cycleIEAbiological_process
GO:0072203cell proliferation involved in metanephros developIEAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0008544epidermis developmentIEAbiological_process
GO:0008158hedgehog receptor activityIEAmolecular_function
GO:0042593glucose homeostasisIEAbiological_process
GO:0030496midbodyIEAcellular_component
GO:0021997neural plate axis specificationIEAbiological_process
GO:0001841neural tube formationIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0009887organ morphogenesisISSbiological_process
GO:0021532neural tube patterningIMPbiological_process
GO:0005901caveolaIDAcellular_component
GO:0005119smoothened bindingIPImolecular_function
GO:0060037pharyngeal system developmentIMPbiological_process
GO:0010157response to chlorateIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0005113patched bindingIEAmolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0030332cyclin bindingIEAmolecular_function
GO:0045879negative regulation of smoothened signaling pathwaISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032880regulation of protein localizationIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0040015negative regulation of multicellular organism growIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process
GO:0035108limb morphogenesisIMPbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0035137hindlimb morphogenesisIEAbiological_process
GO:0072001renal system developmentIEPbiological_process
GO:0060644mammary gland epithelial cell differentiationIEAbiological_process
GO:0016485protein processingIEAbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0015485cholesterol bindingIDAmolecular_function
GO:0061053somite developmentIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0051782negative regulation of cell divisionIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045668negative regulation of osteoblast differentiationIMPbiological_process
GO:0032403protein complex bindingIEAmolecular_function