Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	SMO_HUMAN
Description:	smoothened, frizzled family receptor [Source:HGNC Symbol;Acc:11119]
Location:	chr7 q32.1
Node attribute:	PPI(source); PPI(target)

Phosphorylation site

Position	PhosphoPeptide	Source
S32	GRGAAsSGNAT	PhosphoSitePlus
S47	RSAGGsARRSA	PhosphoSitePlus
S785	LMDADsDF___	PhosphoSitePlus
S43	GPGPRsAGGSA	PhosphoSitePlus

Dephosphorylation site

SMO_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000249373	A652V	COSMIC	Skin Cancer	12499255
ENSP00000249373	V404M	COSMIC	Intestines Cancer	15072830
ENSP00000249373	A324T	COSMIC	Biliary Tract Cancer	17287906
ENSP00000249373	R117L	COSMIC	Head and Neck Cancer	21798893
ENSP00000249373	R562Q	COSMIC	Skin Cancer	9422511
ENSP00000249373	D473H	COSMIC	Central Nervous System Neoplasms	19726788
ENSP00000249373	R290S	Ding2008, COSMIC	Lung Cancer	18948947
ENSP00000249373	W535L	OMIM, HPI	Neoplasms by Histologic Type	9422511, 9422511 11133163
ENSP00000249373	W535L	COSMIC	Skin Cancer	12499255
ENSP00000249373	T640A	COSMIC	Intestines Cancer	15072830
ENSP00000249373	R562Q	OMIM, HPI	Neoplasms by Histologic Type	9422511
ENSP00000249373	R199W	COSMIC	Skin Cancer	15656799
ENSP00000249373	Q148*	COSMIC	Skin Cancer	21984974
ENSP00000249373	K575M	COSMIC	Hepatocellular Carcinoma	16339184
ENSP00000249373	L412F	BIOMART	Brain Cancer	21930507, 21930502
ENSP00000249373	S533N	COSMIC	Central Nervous System Neoplasms	9581815

Differential expressed protein

SMO_HUMAN is not differential expressed protein.

Hyperphosphorylation site

SMO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
SMO_HUMAN	PTC1_HUMAN	other	KEGG
RAB23_HUMAN	SMO_HUMAN	other	KEGG

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05217	Basal cell carcinoma
hsa05200	Pathways in cancer
hsa04340	Hedgehog signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0060684	epithelial-mesenchymal cell signaling	IEA	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0001649	osteoblast differentiation	IBA	biological_process
GO:0007228	positive regulation of hh target transcription fac	ISS	biological_process
GO:0048702	embryonic neurocranium morphogenesis	IBA	biological_process
GO:0032474	otolith morphogenesis	IBA	biological_process
GO:0007224	smoothened signaling pathway	IEA	biological_process
GO:0048752	semicircular canal morphogenesis	IBA	biological_process
GO:0016021	integral to membrane	IEA	cellular_component
GO:0021938	smoothened signaling pathway involved in regulatio	IEA	biological_process
GO:0002052	positive regulation of neuroblast proliferation	IBA	biological_process
GO:0010468	regulation of gene expression	IEA	biological_process
GO:0003140	determination of left/right asymmetry in lateral m	IEA	biological_process
GO:0048565	digestive tract development	IEA	biological_process
GO:0031069	hair follicle morphogenesis	IEA	biological_process
GO:0043066	negative regulation of apoptotic process	IBA	biological_process
GO:2000826	regulation of heart morphogenesis	ISS	biological_process
GO:0001947	heart looping	ISS	biological_process
GO:0021904	dorsal/ventral neural tube patterning	IBA	biological_process
GO:0072372	primary cilium	IEA	cellular_component
GO:2000826	regulation of heart morphogenesis	IEA	biological_process
GO:0005929	cilium	IBA	cellular_component
GO:0005929	cilium	IEA	cellular_component
GO:0002052	positive regulation of neuroblast proliferation	IEA	biological_process
GO:0001649	osteoblast differentiation	IEA	biological_process
GO:0004888	transmembrane signaling receptor activity	IEA	molecular_function
GO:0050821	protein stabilization	IEA	biological_process
GO:0007368	determination of left/right symmetry	IEA	biological_process
GO:0031017	exocrine pancreas development	IBA	biological_process
GO:0001755	neural crest cell migration	IEA	biological_process
GO:0001570	vasculogenesis	IBA	biological_process
GO:0005113	patched binding	IPI	molecular_function
GO:0043392	negative regulation of DNA binding	IEA	biological_process
GO:0007228	positive regulation of hh target transcription fac	IEA	biological_process
GO:0048853	forebrain morphogenesis	IEA	biological_process
GO:0045944	positive regulation of transcription from RNA poly	IEA	biological_process
GO:0042813	Wnt-activated receptor activity	IBA	molecular_function
GO:0061113	pancreas morphogenesis	IEA	biological_process
GO:0021984	adenohypophysis development	IBA	biological_process
GO:0003007	heart morphogenesis	IEA	biological_process
GO:0042307	positive regulation of protein import into nucleus	IEA	biological_process
GO:0002053	positive regulation of mesenchymal cell proliferat	IEA	biological_process
GO:0007371	ventral midline determination	IEA	biological_process
GO:0017147	Wnt-protein binding	IBA	molecular_function
GO:0021508	floor plate formation	IBA	biological_process
GO:0042475	odontogenesis of dentin-containing tooth	IEA	biological_process
GO:0004930	G-protein coupled receptor activity	IEA	molecular_function
GO:0021910	smoothened signaling pathway involved in ventral s	IEA	biological_process
GO:0021904	dorsal/ventral neural tube patterning	IEA	biological_process
GO:0090190	positive regulation of branching involved in urete	IEA	biological_process
GO:0060070	canonical Wnt receptor signaling pathway	IBA	biological_process
GO:0007494	midgut development	ISS	biological_process
GO:0021696	cerebellar cortex morphogenesis	IBA	biological_process
GO:0005737	cytoplasm	IBA	cellular_component
GO:0090190	positive regulation of branching involved in urete	ISS	biological_process
GO:0001708	cell fate specification	IEA	biological_process
GO:0042693	muscle cell fate commitment	IBA	biological_process
GO:0048853	forebrain morphogenesis	ISS	biological_process
GO:0035264	multicellular organism growth	IEA	biological_process
GO:0048846	axon extension involved in axon guidance	IBA	biological_process
GO:0048557	embryonic digestive tract morphogenesis	IBA	biological_process
GO:0072285	mesenchymal to epithelial transition involved in m	ISS	biological_process
GO:0072001	renal system development	IEP	biological_process
GO:0003007	heart morphogenesis	IBA	biological_process
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular_component
GO:0010002	cardioblast differentiation	IBA	biological_process
GO:0007389	pattern specification process	IEA	biological_process
GO:0009953	dorsal/ventral pattern formation	IEA	biological_process
GO:0021910	smoothened signaling pathway involved in ventral s	IBA	biological_process
GO:0001755	neural crest cell migration	IBA	biological_process
GO:0051799	negative regulation of hair follicle development	IEA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0050679	positive regulation of epithelial cell proliferati	IEA	biological_process
GO:0001503	ossification	IEA	biological_process
GO:0048589	developmental growth	IEA	biological_process
GO:0072285	mesenchymal to epithelial transition involved in m	IEA	biological_process
GO:0034504	protein localization to nucleus	IEA	biological_process
GO:0060644	mammary gland epithelial cell differentiation	IEA	biological_process
GO:0001701	in utero embryonic development	IEA	biological_process
GO:0005886	plasma membrane	IBA	cellular_component
GO:2000036	regulation of stem cell maintenance	IEA	biological_process
GO:0007368	determination of left/right symmetry	IBA	biological_process
GO:0061053	somite development	IEA	biological_process
GO:0001947	heart looping	IEA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0005119	smoothened binding	IPI	molecular_function
GO:0008144	drug binding	IDA	molecular_function
GO:0072372	primary cilium	TAS	cellular_component
GO:0010628	positive regulation of gene expression	IEA	biological_process
GO:0050679	positive regulation of epithelial cell proliferati	IBA	biological_process
GO:0060830	ciliary receptor clustering involved in smoothened	IBA	biological_process
GO:0071397	cellular response to cholesterol	IEA	biological_process
GO:0043025	neuronal cell body	IBA	cellular_component
GO:0042475	odontogenesis of dentin-containing tooth	IBA	biological_process
GO:0045880	positive regulation of smoothened signaling pathwa	IBA	biological_process
GO:0005794	Golgi apparatus	IDA	cellular_component
GO:0005901	caveola	IDA	cellular_component
GO:0010629	negative regulation of gene expression	ISS	biological_process
GO:0030857	negative regulation of epithelial cell differentia	IEA	biological_process
GO:0007371	ventral midline determination	ISS	biological_process
GO:0061053	somite development	ISS	biological_process
GO:0010628	positive regulation of gene expression	ISS	biological_process
GO:0002053	positive regulation of mesenchymal cell proliferat	IBA	biological_process
GO:0043392	negative regulation of DNA binding	ISS	biological_process
GO:0021938	smoothened signaling pathway involved in regulatio	IBA	biological_process
GO:0021696	cerebellar cortex morphogenesis	IEA	biological_process
GO:0045880	positive regulation of smoothened signaling pathwa	IEA	biological_process
GO:0007494	midgut development	IEA	biological_process
GO:0007224	smoothened signaling pathway	IEP	biological_process
GO:0043066	negative regulation of apoptotic process	IEA	biological_process
GO:0048663	neuron fate commitment	IBA	biological_process
GO:0001570	vasculogenesis	IEA	biological_process
GO:0008144	drug binding	IEA	molecular_function
GO:0010629	negative regulation of gene expression	IEA	biological_process
GO:0030165	PDZ domain binding	IBA	molecular_function
GO:0007166	cell surface receptor signaling pathway	IEA	biological_process
GO:0048703	embryonic viscerocranium morphogenesis	IBA	biological_process
GO:0008284	positive regulation of cell proliferation	IEA	biological_process
GO:0048468	cell development	IEA	biological_process
GO:0007417	central nervous system development	IEA	biological_process
GO:0008406	gonad development	IBA	biological_process
GO:0007283	spermatogenesis	IBA	biological_process
GO:0021953	central nervous system neuron differentiation	IBA	biological_process
GO:0003323	type B pancreatic cell development	IEA	biological_process
GO:0031076	embryonic camera-type eye development	IBA	biological_process
GO:0071397	cellular response to cholesterol	ISS	biological_process
GO:0021561	facial nerve development	IBA	biological_process
GO:0021953	central nervous system neuron differentiation	IEA	biological_process
GO:0003140	determination of left/right asymmetry in lateral m	ISS	biological_process
GO:0000122	negative regulation of transcription from RNA poly	IEA	biological_process
GO:0031102	neuron projection regeneration	IBA	biological_process
GO:0060248	detection of cell density by contact stimulus invo	IMP	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network