Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SHH_HUMAN
Description:sonic hedgehog [Source:HGNC Symbol;Acc:10848]
Location:chr7 q36.3
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y253AKKVFyVIETRHintPhosphoSitePlus

Dephosphorylation site
SHH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000297261G231SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000297261E368KCOSMICLung Cancer20668451
ENSP00000297261V254MCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000297261LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineDown17449014

Hyperphosphorylation site
SHH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SHH_HUMANBOC_HUMANligand -> receptorHPMR
SHH_HUMANCDON_HUMANligand -> receptorHPMR
SHH_HUMANPTC1_HUMANligand -> receptorHPMR
SHH_HUMANHHIP_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05217Basal cell carcinoma
hsa04340Hedgehog signaling pathway
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060439trachea morphogenesisIEAbiological_process
GO:0007417central nervous system developmentISSbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0034504protein localization to nucleusIEAbiological_process
GO:0060768regulation of epithelial cell proliferation involvIEAbiological_process
GO:0016539intein-mediated protein splicingIEAbiological_process
GO:0060684epithelial-mesenchymal cell signalingIEAbiological_process
GO:0030336negative regulation of cell migrationISSbiological_process
GO:0007228positive regulation of hh target transcription facIEAbiological_process
GO:0030324lung developmentISSbiological_process
GO:0031016pancreas developmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0061053somite developmentIEAbiological_process
GO:0007442hindgut morphogenesisIEAbiological_process
GO:0060173limb developmentIEAbiological_process
GO:0005539glycosaminoglycan bindingIEAmolecular_function
GO:0043588skin developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0060459left lung developmentIEAbiological_process
GO:0033092positive regulation of immature T cell proliferatiIEAbiological_process
GO:0048568embryonic organ developmentIEAbiological_process
GO:0005113patched bindingIEAmolecular_function
GO:0045445myoblast differentiationIEAbiological_process
GO:0045880positive regulation of smoothened signaling pathwaIEAbiological_process
GO:0045059positive thymic T cell selectionISSbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0021938smoothened signaling pathway involved in regulatioIEAbiological_process
GO:2000357negative regulation of kidney smooth muscle cell dIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0014858positive regulation of skeletal muscle cell prolifIEAbiological_process
GO:0005113patched bindingIDAmolecular_function
GO:0048468cell developmentIEAbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0030162regulation of proteolysisIEAbiological_process
GO:0060463lung lobe morphogenesisIEAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0060738epithelial-mesenchymal signaling involved in prostIDAbiological_process
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0045060negative thymic T cell selectionISSbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0008209androgen metabolic processISSbiological_process
GO:0090370negative regulation of cholesterol effluxISSbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0007228positive regulation of hh target transcription facISSbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048864stem cell developmentIEAbiological_process
GO:0033089positive regulation of T cell differentiation in tISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0001947heart loopingISSbiological_process
GO:0009880embryonic pattern specificationTASbiological_process
GO:0021940positive regulation of cerebellar granule cell preIEAbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0048646anatomical structure formation involved in morphogIEAbiological_process
GO:0043237laminin-1 bindingISSmolecular_function
GO:0060447bud outgrowth involved in lung branchingIEAbiological_process
GO:0060662salivary gland cavitationIEAbiological_process
GO:0090370negative regulation of cholesterol effluxIEAbiological_process
GO:0007405neuroblast proliferationISSbiological_process
GO:0048645organ formationIEAbiological_process
GO:0061189positive regulation of sclerotome developmentIDAbiological_process
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0030902hindbrain developmentISSbiological_process
GO:0007267cell-cell signalingISSbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0060840artery developmentIEAbiological_process
GO:0048859formation of anatomical boundaryIEAbiological_process
GO:0030162regulation of proteolysisISSbiological_process
GO:0051781positive regulation of cell divisionIDAbiological_process
GO:2000357negative regulation of kidney smooth muscle cell dISSbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0003140determination of left/right asymmetry in lateral mISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0051155positive regulation of striated muscle cell differIEAbiological_process
GO:0048617embryonic foregut morphogenesisIEAbiological_process
GO:0007411axon guidanceISSbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0009953dorsal/ventral pattern formationISSbiological_process
GO:0042127regulation of cell proliferationISSbiological_process
GO:0001569patterning of blood vesselsISSbiological_process
GO:0043369CD4-positive or CD8-positive, alpha-beta T cell liIDAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0010463mesenchymal cell proliferationIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0001822kidney developmentIEAbiological_process
GO:2000062negative regulation of ureter smooth muscle cell dISSbiological_process
GO:0060438trachea developmentIEAbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0007405neuroblast proliferationIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0007224smoothened signaling pathwayISSbiological_process
GO:0007596blood coagulationIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:2000358positive regulation of kidney smooth muscle cell dIEAbiological_process
GO:0048856anatomical structure developmentIEAbiological_process
GO:0001656metanephros developmentISSbiological_process
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0060769positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0043369CD4-positive or CD8-positive, alpha-beta T cell liIEAbiological_process
GO:0072001renal system developmentIEPbiological_process
GO:0060516primary prostatic bud elongationIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0060782regulation of mesenchymal cell proliferation involIEAbiological_process
GO:0060020Bergmann glial cell differentiationIEAbiological_process
GO:0060174limb bud formationIEAbiological_process
GO:2000063positive regulation of ureter smooth muscle cell dISSbiological_process
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0030850prostate gland developmentIEAbiological_process
GO:0051146striated muscle cell differentiationIEAbiological_process
GO:0021978telencephalon regionalizationIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0048839inner ear developmentIEAbiological_process
GO:0072136metanephric mesenchymal cell proliferation involveIEAbiological_process
GO:0045109intermediate filament organizationIEAbiological_process
GO:2000062negative regulation of ureter smooth muscle cell dIEAbiological_process
GO:0030901midbrain developmentIEAbiological_process
GO:0046639negative regulation of alpha-beta T cell differentIEAbiological_process
GO:0032435negative regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0072136metanephric mesenchymal cell proliferation involveISSbiological_process
GO:0001658branching involved in ureteric bud morphogenesisISSbiological_process
GO:2000358positive regulation of kidney smooth muscle cell dISSbiological_process
GO:0060425lung morphogenesisIEAbiological_process
GO:0060664epithelial cell proliferation involved in salivaryIEAbiological_process
GO:0007418ventral midline developmentTASbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0002320lymphoid progenitor cell differentiationIMPbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0048538thymus developmentISSbiological_process
GO:0001570vasculogenesisISSbiological_process
GO:0035115embryonic forelimb morphogenesisIEAbiological_process
GO:0042733embryonic digit morphogenesisISSbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0060442branching involved in prostate gland morphogenesisIEAbiological_process
GO:2000063positive regulation of ureter smooth muscle cell dIEAbiological_process
GO:0030323respiratory tube developmentIEAbiological_process
GO:0048714positive regulation of oligodendrocyte differentiaIEAbiological_process
GO:0014003oligodendrocyte developmentIEAbiological_process
GO:0042481regulation of odontogenesisISSbiological_process
GO:0033089positive regulation of T cell differentiation in tIEAbiological_process
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0006897endocytosisIEAbiological_process
GO:0060484lung-associated mesenchyme developmentIEAbiological_process
GO:0048754branching morphogenesis of a tubeISSbiological_process
GO:0030539male genitalia developmentISSbiological_process
GO:0045121membrane raftISScellular_component
GO:2000729positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0060685regulation of prostatic bud formationIEAbiological_process
GO:0046638positive regulation of alpha-beta T cell differentISSbiological_process
GO:0080125multicellular structure septum developmentIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0030539male genitalia developmentIEAbiological_process
GO:0001948glycoprotein bindingIEAmolecular_function
GO:0007417central nervous system developmentIEAbiological_process
GO:0007398ectoderm developmentIEAbiological_process
GO:0030326embryonic limb morphogenesisISSbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0030850prostate gland developmentISSbiological_process
GO:0004871signal transducer activityIDAmolecular_function
GO:0042476odontogenesisIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0030901midbrain developmentISSbiological_process
GO:0048643positive regulation of skeletal muscle tissue deveIEAbiological_process
GO:0042177negative regulation of protein catabolic processIEAbiological_process
GO:2000729positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0033092positive regulation of immature T cell proliferatiISSbiological_process
GO:0045880positive regulation of smoothened signaling pathwaISSbiological_process
GO:0048598embryonic morphogenesisIEAbiological_process
GO:0009986cell surfaceISScellular_component
GO:0016020membraneIEAcellular_component
GO:0009790embryo developmentISSbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:1900180regulation of protein localization to nucleusIDAbiological_process
GO:0014706striated muscle tissue developmentIEAbiological_process
GO:0007507heart developmentISSbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathIEAbiological_process
GO:0046638positive regulation of alpha-beta T cell differentIEAbiological_process
GO:0007389pattern specification processISSbiological_process
GO:0042307positive regulation of protein import into nucleusIEAbiological_process
GO:0003140determination of left/right asymmetry in lateral mIEAbiological_process
GO:0060441epithelial tube branching involved in lung morphogIEAbiological_process
GO:0005615extracellular spaceISScellular_component
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0045596negative regulation of cell differentiationISSbiological_process
GO:0043237laminin-1 bindingIEAmolecular_function
GO:0048706embryonic skeletal system developmentIEAbiological_process
GO:1900175regulation of nodal signaling pathway involved in NASbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0060783mesenchymal smoothened signaling pathway involved IEAbiological_process
GO:0060428lung epithelium developmentIEAbiological_process
GO:0048468cell developmentISSbiological_process
GO:0060458right lung developmentIEAbiological_process
GO:0002320lymphoid progenitor cell differentiationIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0034244negative regulation of transcription elongation frIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0014902myotube differentiationIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0060916mesenchymal cell proliferation involved in lung deIEAbiological_process
GO:0021513spinal cord dorsal/ventral patterningIEAbiological_process
GO:0061053somite developmentISSbiological_process
GO:0045059positive thymic T cell selectionIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0008219cell deathIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0001755neural crest cell migrationISSbiological_process
GO:0016015morphogen activityNASmolecular_function
GO:0043010camera-type eye developmentIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030878thyroid gland developmentIEAbiological_process
GO:0060523prostate epithelial cord elongationIEAbiological_process
GO:0048864stem cell developmentISSbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0048663neuron fate commitmentISSbiological_process
GO:0008209androgen metabolic processIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0001708cell fate specificationISSbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0030010establishment of cell polarityIEAbiological_process
GO:0030900forebrain developmentISSbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0008233peptidase activityIEAmolecular_function