| UniProt/SwissProt ID: | PTBP1_HUMAN |
| Description: | polypyrimidine tract binding protein 1 [Source:HGNC Symbol;Acc:9583] |
| Location: | chr19 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S459 | KDYGNsPLHRF | HPRD | |
| T22 | DELFStCVTNG | PhosphoSitePlus | |
| S16 | GTKRGsDELFS | PhosphoSitePlus; phosphoELM; SysPTM | |
| S272 | YNNDKsRDYTR | PhosphoSitePlus | |
| S16 | GTKRGsDELFS | PRKACA | HPRD; SysPTM |
| T446 | EDQGLtKDYGN | HPRD | |
| T427 | EDQGLtKDYGN | PhosphoSitePlus; HPRD | |
| S53 | KGDSRsAGVPS | PhosphoSitePlus | |
| S21 | SDELFsTCVTN | PhosphoSitePlus | |
| S141 | LKTDSsPNQAR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S16 | GTKRGsDELFS | PKA_group | phosphoELM; RegPhos; SysPTM |
| S433 | KDYGNsPLHRF | PhosphoSitePlus; HPRD; RegPhos; SysPTM | |
| Y430 | GLTKDyGNSPL | PhosphoSitePlus | |
| S443 | FKKPGsKNFQN | PhosphoSitePlus; HPRD | |
| Y193 | VENLFyPVTLD | PhosphoSitePlus | |
| S16 | GTKRGsDELFS | PKACa | RegPhos; SysPTM |
| S469 | FKKPGsKNFQN | HPRD | |
| S462 | FKKPGsKNFQN | HPRD | |
| Y127 | RGQPIyIQFSN | HPRD; phosphoELM; RegPhos | |
| S140 | ELKTDsSPNQA | PhosphoSitePlus; HPRD; SysPTM | |
| S37 | SSNSAsAANGN | HPRD | |
| Y127 | RGQPIyIQFSN | RRM_5 | PhosphoSitePlus |
| S452 | KDYGNsPLHRF | HPRD | |
| T453 | EDQGLtKDYGN | HPRD | |
| Y267 | SLNVKyNNDKS | PhosphoSitePlus | |
| T138 | HKELKtDSSPN | PhosphoSitePlus; HPRD | |
| S35 | IMSSNsASAAN | HPRD | |
| S131 | IYIQFsNHKEL | RRM_5 | PhosphoSitePlus |
| T12 | DIAVGtKRGSD | PhosphoSitePlus | |
| Dephosphorylation site |
| PTBP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000349428 | T138I | COSMIC | Skin Cancer | 21984974 | ENSP00000349428 | A311V | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000014112 | *532R | COSMIC | Breast Cancer | 20668451 | ENSP00000014112 | *532R | COSMIC | Breast Cancer | 20668451 | ENSP00000349428 | T71M | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000349428 | T71M | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000349428 | G310R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000349428 | F222L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000349428 | G310R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000349428 | F222L | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000014112 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000014112 | Breast Cancer | Treatment (Antiestrogen-sensitive vs. Antiestrogen-resistant) | cell line | Up | 14557597 | ENSP00000014112 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Down | 0.4 | 20804217 | ENSP00000014112 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| PTBP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK9_HUMAN | PTBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK03_HUMAN | PTBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | PTBP1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | PTBP1_HUMAN | kinase -> substrate | HPRD |
| CDKL5_HUMAN | PTBP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PTBP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0033119 | negative regulation of RNA splicing | IDA | biological_process |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0005730 | nucleolus | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0036002 | pre-mRNA binding | IDA | molecular_function |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0000381 | regulation of alternative mRNA splicing, via splic | IDA | biological_process |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0008187 | poly-pyrimidine tract binding | TAS | molecular_function |
| GO:0048025 | negative regulation of mRNA splicing, via spliceos | IDA | biological_process |
| GO:0051148 | negative regulation of muscle cell differentiation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003723 | RNA binding | TAS | molecular_function |