| UniProt/SwissProt ID: | PPAC_HUMAN |
| Description: | acid phosphatase 1, soluble [Source:HGNC Symbol;Acc:122] |
| Location: | chr2 p25.3 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S20 | GNICRsPIAEA | LMWPc | PhosphoSitePlus |
| S20 | GNICRsPIAEA | HPRD | |
| Y50 | AATSGyEIGNP | LMWPc | PhosphoSitePlus |
| Y133 | IEDPYyGNDSD | RegPhos | |
| Y133 | IEDPYyGNDSD | LCK | HPRD; RegPhos |
| Y132 | IIEDPyYGNDS | LMWPc | PhosphoSitePlus |
| T79 | VARQItKEDFA | LMWPc | PhosphoSitePlus |
| Y133 | IEDPYyGNDSD | LMWPc | PhosphoSitePlus |
| Y132 | IIEDPyYGNDS | HPRD; phosphoELM; RegPhos | |
| Y133 | IEDPYyGNDSD | FYN | HPRD; RegPhos |
| T32 | FRKLVtDQNIS | HPRD | |
| T85 | KEDFAtFDYIL | LMWPc | PhosphoSitePlus |
| S62 | DYRGQsCMKRH | LMWPc | PhosphoSitePlus |
| Y132 | IIEDPyYGNDS | LCK | HPRD; RegPhos |
| S137 | YYGNDsDFETV | LMWPc | PhosphoSitePlus |
| Y120 | ELLGSyDPQKQ | LMWPc | PhosphoSitePlus |
| Y132 | IIEDPyYGNDS | FYN | HPRD; RegPhos |
| T141 | DSDFEtVYQQC | LMWPc | PhosphoSitePlus |
| Y88 | FATFDyILCMD | LMWPc | PhosphoSitePlus |
| Y143 | DFETVyQQCVR | LMWPc | PhosphoSitePlus |
| Dephosphorylation site |
| PPAC_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PPAC_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000272065 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.28 | 18646787 | ENSP00000272065 | hepatitis B virus | Normal vs. Cancer | cell line | Up | 2.7 | 19626621 | ENSP00000272065 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 0.47 | 19016532 |
| Hyperphosphorylation site |
| PPAC_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LCK_HUMAN | PPAC_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | PPAC_HUMAN | kinase -> substrate | RegPhos |
| FYN_HUMAN | PPAC_HUMAN | kinase -> substrate | RegPhos |
| PPAC_HUMAN | SPTN1_HUMAN | phosphatase -> substrate | HPRD |
| PPAC_HUMAN | ZAP70_HUMAN | phosphatase -> substrate | HPRD; NetPath |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04520 | Adherens junction |
| hsa00740 | Riboflavin metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009898 | internal side of plasma membrane | IDA | cellular_component |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | biological_process |
| GO:0003993 | acid phosphatase activity | IEA | molecular_function |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |