Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PK3CG_HUMAN
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [Source:HGNC Symbol;Acc:8978]
Location:chr7 q22.3
Node attribute:kinase; effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1101QGEKHHPRD
T607EIVAKtYQLLAPI3KaPhosphoSitePlus
S620EVWDQsALDVGPI3KaPhosphoSitePlus
S1101QGEKHPIK3CGphosphoELM
Y757LSAEKyDVSSQPhosphoSitePlus
T250LQSFFtKMAKKPI3K_rbdPhosphoSitePlus
S1101QGEKHsARegPhos
T1024ALRHHtNLLIIPI3_PI4_kinasePhosphoSitePlus
T627LDVGLtMQLLDPI3KaPhosphoSitePlus
S230HRSTTsQTIKVPI3K_rbdPhosphoSitePlus
T228VIHRStTSQTIPI3K_rbdPhosphoSitePlus
S227IVIHRsTTSQTPI3K_rbdPhosphoSitePlus
T229IHRSTtSQTIKPI3K_rbdPhosphoSitePlus
S1101QGEKHsA____PhosphoSitePlus
S1101QGEKHsAPIK3R4RegPhos
S636LDCNFsDENVRPI3KaPhosphoSitePlus

Dephosphorylation site
PK3CG_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000419260R552CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000392258E511KCOSMICLung Cancer
ENSP00000392258R18QCOSMICCentral Nervous System Neoplasms18772890
ENSP00000352121E602VCOSMICLung Cancer20668451
ENSP00000352121S760RTCGAOvarian Cancer21720365, 18772890
ENSP00000392258E740KCOSMICBreast Cancer20668451
ENSP00000392258T1024KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000392258E602VCOSMICLung Cancer20668451
ENSP00000392258L379ICOSMICOvarian Cancer21720365
ENSP00000419260K52*COSMICLung Cancer18948947
ENSP00000419260T1024KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000419260P563RCOSMICLung Cancer18948947
ENSP00000392258K52*COSMICLung Cancer18948947
ENSP00000419260L843HCOSMICHead and Neck Cancer21798893
ENSP00000352121K364NCOSMICLung Cancer20668451
ENSP00000392258G491ECOSMICHead and Neck Cancer21798897
ENSP00000392258A445STCGAOvarian Cancer21720365, 18772890
ENSP00000392258P1004LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121G966WDing2008, COSMICLung Cancer18948947
ENSP00000352121R21WBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000352121K52*Ding2008, COSMICLung Cancer18948947
ENSP00000352121S760RCOSMICOvarian Cancer21720365
ENSP00000419260L58MCOSMICLung Cancer18948947
ENSP00000392258R178LCOSMICLung Cancer20668451
ENSP00000352121T1024KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000419260V616DBIOMARTBreast Cancer21930507, 21930502
ENSP00000352121P563RDing2008, COSMICLung Cancer18948947
ENSP00000419260R178LCOSMICLung Cancer20668451
ENSP00000352121S348ICOSMICLung Cancer20668451
ENSP00000419260L379ITCGAOvarian Cancer21720365, 18772890
ENSP00000419260S353FCOSMICSkin Cancer21984974
ENSP00000419260C936STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121T503MCOSMICBreast Cancer20668451
ENSP00000419260K364NCOSMICLung Cancer20668451
ENSP00000352121R18QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121A445STCGAOvarian Cancer21720365, 18772890
ENSP00000392258R552CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000352121D161ECOSMICLung Cancer20668451
ENSP00000419260A445STCGAOvarian Cancer21720365, 18772890
ENSP00000352121S353FCOSMICSkin Cancer21984974
ENSP00000419260G491ECOSMICHead and Neck Cancer21798897
ENSP00000352121C936SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000392258S348ICOSMICLung Cancer20668451
ENSP00000392258A445SCOSMICOvarian Cancer21720365
ENSP00000392258P526SCOSMICHead and Neck Cancer21798893
ENSP00000352121A621SCOSMICGastric Cancer21097718
ENSP00000352121R839CCOSMICPancreatic Cancer
ENSP00000392258R839CCOSMICPancreatic Cancer
ENSP00000352121E740KCOSMICBreast Cancer20668451
ENSP00000352121L379ICOSMICOvarian Cancer21720365
ENSP00000392258R552CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000419260A621SCOSMICGastric Cancer21097718
ENSP00000392258V616DBIOMARTBreast Cancer21930507, 21930502
ENSP00000392258L379ITCGAOvarian Cancer21720365, 18772890
ENSP00000392258D161ECOSMICLung Cancer20668451
ENSP00000419260S760RCOSMICOvarian Cancer21720365
ENSP00000419260R90WCOSMICGastric Cancer21097718
ENSP00000419260G966WCOSMICLung Cancer18948947
ENSP00000392258S446FCOSMICHead and Neck Cancer21798893
ENSP00000352121A445VBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000352121A666DCOSMICSkin Cancer21984974
ENSP00000419260E602VCOSMICLung Cancer20668451
ENSP00000419260R552CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121G491VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000419260S446FCOSMICHead and Neck Cancer21798893
ENSP00000419260P1004LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121R552CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000392258K364NCOSMICLung Cancer20668451
ENSP00000352121C936STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000419260R1021SCOSMICHead and Neck Cancer21798893
ENSP00000392258C936SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000392258G966WCOSMICLung Cancer18948947
ENSP00000352121G426ECOSMICLung Cancer
ENSP00000392258R90WCOSMICGastric Cancer21097718
ENSP00000392258G426ECOSMICLung Cancer
ENSP00000419260R18QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000392258P563RCOSMICLung Cancer18948947
ENSP00000352121G491ECOSMICHead and Neck Cancer21798897
ENSP00000352121R90WCOSMICGastric Cancer21097718
ENSP00000352121A445SCOSMICOvarian Cancer21720365
ENSP00000419260E511KCOSMICLung Cancer
ENSP00000419260A445SCOSMICOvarian Cancer21720365
ENSP00000392258S760RCOSMICOvarian Cancer21720365
ENSP00000352121L58MDing2008, COSMICLung Cancer18948947
ENSP00000392258T503MCOSMICBreast Cancer20668451
ENSP00000352121N66KCOSMICLung Cancer20668451
ENSP00000419260P526SCOSMICHead and Neck Cancer21798893
ENSP00000392258N66KCOSMICLung Cancer20668451
ENSP00000352121R18QCOSMICCentral Nervous System Neoplasms18772890
ENSP00000419260R839CCOSMICPancreatic Cancer
ENSP00000392258A621SCOSMICGastric Cancer21097718
ENSP00000419260L379ICOSMICOvarian Cancer21720365
ENSP00000392258R1021SCOSMICHead and Neck Cancer21798893
ENSP00000392258L58MCOSMICLung Cancer18948947
ENSP00000352121T1024KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000419260G426ECOSMICLung Cancer
ENSP00000352121R542WCOSMICBreast Cancer20668451
ENSP00000392258R18QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121R552CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000352121S446FCOSMICHead and Neck Cancer21798893
ENSP00000352121P1004LTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000392258P1004LCOSMICSkin Cancer21984974
ENSP00000419260E740KCOSMICBreast Cancer20668451
ENSP00000392258T1024KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000419260D161ECOSMICLung Cancer20668451
ENSP00000392258R542WCOSMICBreast Cancer20668451
ENSP00000352121P1004LCOSMICSkin Cancer21984974
ENSP00000352121P526SCOSMICHead and Neck Cancer21798893
ENSP00000419260T503MCOSMICBreast Cancer20668451
ENSP00000352121L843HCOSMICHead and Neck Cancer21798893
ENSP00000352121E511KCOSMICLung Cancer
ENSP00000419260S348ICOSMICLung Cancer20668451
ENSP00000392258L843HCOSMICHead and Neck Cancer21798893
ENSP00000352121R1021SCOSMICHead and Neck Cancer21798893
ENSP00000419260R542WCOSMICBreast Cancer20668451
ENSP00000419260T1024KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000419260P1004LCOSMICSkin Cancer21984974
ENSP00000419260A666DCOSMICSkin Cancer21984974
ENSP00000419260N66KCOSMICLung Cancer20668451
ENSP00000352121L379ITCGAOvarian Cancer21720365, 18772890
ENSP00000419260R18QCOSMICCentral Nervous System Neoplasms18772890
ENSP00000392258S760RTCGAOvarian Cancer21720365, 18772890
ENSP00000352121R178LCOSMICLung Cancer20668451
ENSP00000392258A666DCOSMICSkin Cancer21984974
ENSP00000392258S353FCOSMICSkin Cancer21984974
ENSP00000419260S760RTCGAOvarian Cancer21720365, 18772890
ENSP00000419260C936SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000352121V616DBIOMARTBreast Cancer21930507, 21930502
ENSP00000392258C936STCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352121Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.3615169874

Hyperphosphorylation site
PK3CG_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG3_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG12_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG8_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG11_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG1_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBB3_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG10_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GNAQ_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG13_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBB1_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBB5_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG5_HUMANPK3CG_HUMANGprotein -> effectorgpDB
GBG2_HUMANPK3CG_HUMANGprotein -> effectorgpDB
PI3R4_HUMANPK3CG_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANPK3CG_HUMANkinase -> substrateRegPhos
PK3CG_HUMANTPM2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05222Small cell lung cancer
hsa04666Fc gamma R-mediated phagocytosis
hsa05164Influenza A
hsa04722Neurotrophin signaling pathway
hsa04210Apoptosis
hsa04662B cell receptor signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa05162Measles
hsa05166HTLV-I infection
hsa05100Bacterial invasion of epithelial cells
hsa04380Osteoclast differentiation
hsa05221Acute myeloid leukemia
hsa04664Fc epsilon RI signaling pathway
hsa04630Jak-STAT signaling pathway
hsa00562Inositol phosphate metabolism
hsa04370VEGF signaling pathway
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04910Insulin signaling pathway
hsa05211Renal cell carcinoma
hsa04973Carbohydrate digestion and absorption
hsa04012ErbB signaling pathway
hsa05160Hepatitis C
hsa05145Toxoplasmosis
hsa04150mTOR signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05218Melanoma
hsa04620Toll-like receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04930Type II diabetes mellitus
hsa05213Endometrial cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa04960Aldosterone-regulated sodium reabsorption
hsa04062Chemokine signaling pathway
hsa05146Amoebiasis
hsa04660T cell receptor signaling pathway
hsa05223Non-small cell lung cancer
hsa05215Prostate cancer
hsa05210Colorectal cancer
hsa04810Regulation of actin cytoskeleton
hsa04725Cholinergic synapse
hsa05203Viral carcinogenesis
hsa04670Leukocyte transendothelial migration
hsa05169Epstein-Barr virus infection
hsa04510Focal adhesion
hsa04914Progesterone-mediated oocyte maturation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043406positive regulation of MAP kinase activityIDAbiological_process
GO:0042110T cell activationTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0001816cytokine productionTASbiological_process
GO:0032252secretory granule localizationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0006897endocytosisIEAbiological_process
GO:0043303mast cell degranulationTASbiological_process
GO:0004672protein kinase activityTASmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIEAbiological_process
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase actIEAmolecular_function
GO:0002679respiratory burst involved in defense responseTASbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIDAbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0010818T cell chemotaxisTASbiological_process
GO:0055118negative regulation of cardiac muscle contractionTASbiological_process
GO:0002675positive regulation of acute inflammatory responseIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0097284hepatocyte apoptotic processIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0035747natural killer cell chemotaxisTASbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0030593neutrophil chemotaxisTASbiological_process
GO:0042098T cell proliferationTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:00059441-phosphatidylinositol-4-phosphate 3-kinase, classIDAcellular_component
GO:0006954inflammatory responseTASbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityIEAmolecular_function
GO:0016020membraneIDAcellular_component
GO:0005942phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0051897positive regulation of protein kinase B signaling IDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0033628regulation of cell adhesion mediated by integrinTASbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0010897negative regulation of triglyceride catabolic procIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0002250adaptive immune responseTASbiological_process
GO:0072672neutrophil extravasationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0070527platelet aggregationTASbiological_process
GO:0035004phosphatidylinositol 3-kinase activityTASmolecular_function
GO:0046875ephrin receptor bindingIPImolecular_function