| UniProt/SwissProt ID: | TPM2_HUMAN |
| Description: | tropomyosin 2 (beta) [Source:HGNC Symbol;Acc:12011] |
| Location: | chr9 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S158 | HIAEDsDRKYE | Tropomyosin | PhosphoSitePlus |
| S87 | EADVAsLNRRI | HPRD | |
| Y221 | TKEDKyEEEIK | Tropomyosin | PhosphoSitePlus |
| Y267 | AQKMKyKAISE | Tropomyosin | PhosphoSitePlus |
| T108 | QERLAtALQKL | Tropomyosin | PhosphoSitePlus |
| S63 | EKYSEsVKEAQ | Tropomyosin | PhosphoSitePlus |
| Y60 | DEVEKySESVK | Tropomyosin | PhosphoSitePlus |
| T252 | AKLEKtIDDLE | HPRD | |
| S283 | LNDITsL____ | Tropomyosin | PhosphoSitePlus |
| T53 | KKLKGtEDEVE | Tropomyosin | PhosphoSitePlus |
| T252 | AKLEKtIDDLE | Tropomyosin | PhosphoSitePlus |
| T79 | AEKKAtDAEAD | Tropomyosin | PhosphoSitePlus |
| S87 | EADVAsLNRRI | Tropomyosin | PhosphoSitePlus |
| S61 | EVEKYsESVKE | PIK3CG | HPRD |
| Y162 | DSDRKyEEVAR | Tropomyosin | PhosphoSitePlus |
| Y261 | LEDEVyAQKMK | Tropomyosin | PhosphoSitePlus |
| T282 | ALNDItSL___ | Tropomyosin | PhosphoSitePlus |
| Dephosphorylation site |
| TPM2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354219 | V64L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000367542 | E122D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000354219 | E122D | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000354219 | Breast Cancer | Metastasis | cell line | Up | 16637015 | ENSP00000354219 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.1 | 19142970 | ENSP00000354219 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.2 | 19142970 | ENSP00000354219 | Oral Cancer | Normal vs. Cancer | tissue | Up | 6 | 16889763 | ENSP00000354219 | Breast Cancer | Metastasis | cell line | Up | 16637015 | ENSP00000354219 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 16762624 | ENSP00000354219 | Lung Cancer | Cancer vs. Cancer | cell line | Up | 17284061 | ENSP00000354219 | Breast Cancer | Normal vs. Cancer | tissue | Up | 20560667 | ENSP00000354219 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.6 | 20739354 | ENSP00000354219 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.6 | 20739354 | ENSP00000354219 | Ovarian Cancer | Metastasis | cell line | Down | 17892554 | ENSP00000354219 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 4.7 | 15761955 | ENSP00000354219 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 16051329 | ENSP00000354219 | Uterine Cancer | Normal vs. Cancer | tissue | Down | 19771267 | ENSP00000354219 | pancreatic ductal adenocarcinoma | Normal vs. Cancer | tissue | Up | 17492507 |
| Hyperphosphorylation site |
| TPM2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PK3CG_HUMAN | TPM2_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05414 | Dilated cardiomyopathy |
| hsa04260 | Cardiac muscle contraction |
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003779 | actin binding | IDA | molecular_function |
| GO:0043462 | regulation of ATPase activity | IDA | biological_process |
| GO:0005862 | muscle thin filament tropomyosin | TAS | cellular_component |
| GO:0008307 | structural constituent of muscle | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030049 | muscle filament sliding | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006936 | muscle contraction | TAS | biological_process |