Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PER1_HUMAN
Description:period circadian clock 1 [Source:HGNC Symbol;Acc:8845]
Location:chr17 p13.1
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S159RGKGRsGTLATPhosphoSitePlus
S72QRSSHsSSSGNPhosphoSitePlus
S1103FGSIDsSEAEAPhosphoSitePlus; HPRD
S979FNSRCsSPLQLPhosphoSitePlus; HPRD; phosphoELM
S1262GAKASsSQDLAPhosphoSitePlus; HPRD; phosphoELM
S1186LGAVHsWVRKGPhosphoSitePlus; HPRD; SysPTM
T702PVVGGtLSPLAPhosphoSitePlus
S1276EEEGRsSSSPAPhosphoSitePlus
T164SGTLAtLQYALPhosphoSitePlus; HPRD
S980NSRCSsPLQLNPhosphoSitePlus; HPRD; phosphoELM
S837RHHCRsKAKRSPhosphoSitePlus
S1100SKYFGsIDSSEPhosphoSitePlus; HPRD
T677PVSVGtKKDPPPhosphoSitePlus
T692SGEGAtPRKEPPhosphoSitePlus
S1279GRSSSsPALPTPhosphoSitePlus; HPRD
S757PGPAPsPAPSPPhosphoSitePlus
Y167LATLQyALACVPhosphoSitePlus
S592ALPCQsPDPELPhosphoSitePlus
S1104GSIDSsEAEAGPhosphoSitePlus; HPRD
Y107SSSIAySLLSAPhosphoSitePlus
S704VGGTLsPLALAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S1263AKASSsQDLAMPhosphoSitePlus; HPRD; phosphoELM
T161KGRSGtLATLQPhosphoSitePlus; HPRD
S815SSTAPsALGERPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
PER1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314420Q846*COSMICOvarian Cancer21720365
ENSP00000314420P403ACOSMICOvarian Cancer21720365
ENSP00000314420S1060LHPIColorectal Cancer16959974
ENSP00000314420E696QSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000314420D218NCOSMICMelanoma
ENSP00000314420P355SCOSMICMelanoma21499247
ENSP00000314420N985SSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000314420R1162WCOSMICLung Cancer20668451
ENSP00000314420S1060LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000314420L397MCOSMICHead and Neck Cancer21798893

Differential expressed protein
PER1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PER1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1D_HUMANPER1_HUMANkinase -> substrateKEGG
STK4_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
PER1_HUMANPER1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04710Circadian rhythm - mammal
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007623circadian rhythmIEAbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0032922circadian regulation of gene expressionIDAbiological_process
GO:0000988protein binding transcription factor activityIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0009416response to light stimulusIEAbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0009649entrainment of circadian clockTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function