| UniProt/SwissProt ID: | PACS1_HUMAN |
| Description: | phosphofurin acidic cluster sorting protein 1 [Source:HGNC Symbol;Acc:30032] |
| Location: | chr11 q13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S278 | DIDNYsEEEEE | CK2_group | phosphoELM; RegPhos |
| S113 | EVDRSsSSCVP | PhosphoSitePlus | |
| S411 | MSQSSsQTEIG | PhosphoSitePlus | |
| Y303 | GQDLFyEDEDL | PhosphoSitePlus | |
| S493 | TDLQGsASPSK | PhosphoSitePlus; HPRD; phosphoELM | |
| S112 | WEVDRsSSSCV | PhosphoSitePlus | |
| S278 | DIDNYsEEEEE | CK2a1-rs | RegPhos |
| S381 | YNPSDsGPEME | HPRD; phosphoELM | |
| S278 | DIDNYsEEEEE | CSNK2A1 | HPRD |
| S115 | DRSSSsCVPRL | PhosphoSitePlus | |
| S278 | DIDNYsEEEEE | CK2a1 | RegPhos |
| Y672 | HPVAKyLGSVD | Pacs-1 | PhosphoSitePlus |
| S28 | SGVAQsPQQPP | PhosphoSitePlus; RegPhos | |
| T319 | TRRKLtSTSAI | PhosphoSitePlus | |
| T46 | PPQQPtPPKLA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S407 | FFEGMsQSSSQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S322 | KLTSTsAITRQ | PhosphoSitePlus | |
| S687 | SSFLDsGWRDL | Pacs-1 | PhosphoSitePlus |
| T504 | VEGVHtPRQKR | PhosphoSitePlus; HPRD; phosphoELM | |
| S651 | LANKTsDWLGY | Pacs-1 | PhosphoSitePlus |
| S495 | LQGSAsPSKVE | PhosphoSitePlus; HPRD; phosphoELM | |
| S252 | EIKIYsLSSQP | PhosphoSitePlus | |
| T526 | PLSERtNSSDS | PhosphoSitePlus; HPRD | |
| S410 | GMSQSsSQTEI | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S510 | PRQKRsTPLKE | PhosphoSitePlus | |
| T124 | RLFSLtLKKLV | HPRD | |
| T488 | MKSSKtDLQGS | PhosphoSitePlus | |
| S255 | IYSLSsQPIDH | PhosphoSitePlus | |
| Y370 | DLDELyDSLEM | PhosphoSitePlus | |
| S528 | SERTNsSDSER | PhosphoSitePlus; HPRD; phosphoELM | |
| S320 | RRKLTsTSAIT | PhosphoSitePlus | |
| Y680 | SVDSKySSSFL | Pacs-1 | PhosphoSitePlus |
| S114 | VDRSSsSCVPR | PhosphoSitePlus | |
| Y613 | TRIQRyCNCNS | Pacs-1 | PhosphoSitePlus |
| S430 | GKDTTsPMELA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S497 | GSASPsKVEGV | PhosphoSitePlus; HPRD; phosphoELM | |
| S845 | KRDASsKNTLK | Pacs-1 | PhosphoSitePlus |
| Y549 | PRKVVyDQLNQ | Pacs-1 | PhosphoSitePlus |
| S531 | TNSSDsERSPD | PhosphoSitePlus; HPRD; phosphoELM | |
| T413 | QSSSQtEIGSL | PhosphoSitePlus | |
| T511 | RQKRStPLKER | PhosphoSitePlus | |
| S529 | ERTNSsDSERS | PhosphoSitePlus; HPRD; phosphoELM | |
| T848 | ASSKNtLKSVF | Pacs-1 | PhosphoSitePlus |
| Y104 | VQMNLyATWEV | PhosphoSitePlus | |
| S534 | SDSERsPDLGH | PhosphoSitePlus; HPRD; phosphoELM | |
| S278 | DIDNYsEEEEE | PhosphoSitePlus | |
| S779 | SLTVPsTSPPS | Pacs-1 | PhosphoSitePlus |
| T429 | LGKDTtSPMEL | HPRD; RegPhos | |
| S844 | DKRDAsSKNTL | Pacs-1 | PhosphoSitePlus |
| Y251 | AEIKIySLSSQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S379 | EMYNPsDSGPE | PhosphoSitePlus; HPRD; phosphoELM | |
| T321 | RKLTStSAITR | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S278 | SPDIDNYsEEEEESF | PPP2CB | HPRD |
| S278 | SPDIDNYsEEEEESF | PPP2CA | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316454 | R203W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316454 | R709G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316454 | R709G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316454 | V602M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316454 | S59C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316454 | V602M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316454 | S59C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000316454 | R203W | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| PACS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PACS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | PACS1_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | PACS1_HUMAN | kinase -> substrate | RegPhos |
| PP2AA_HUMAN | PACS1_HUMAN | phosphatase -> substrate | HPRD |
| PP2AB_HUMAN | PACS1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PACS1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0044325 | ion channel binding | IPI | molecular_function |
| GO:0000042 | protein targeting to Golgi | IEA | biological_process |
| GO:0030137 | COPI-coated vesicle | IEA | cellular_component |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0050690 | regulation of defense response to virus by virus | TAS | biological_process |
| GO:0072661 | protein targeting to plasma membrane | IMP | biological_process |