Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PA24A_HUMAN
Description:phospholipase A2, group IVA (cytosolic, calcium-dependent) [Source:HGNC Symbol;Acc:9035]
Location:chr1 q31.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T31RATKVtKGAFGC2PhosphoSitePlus
S458GSDYQsDNQASPLA2_BPhosphoSitePlus
S724RRQNPsRCSVSHPRD; phosphoELM
S729SRCSVsLSNVEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S454NEDAGsDYQSDPLA2_BPhosphoSitePlus
T447HEPKGtENEDAPLA2_BPhosphoSitePlus
S727NPSRCsVSLSNRPS6KA5HPRD
S435VSNDSsDSDDEPLA2_BPhosphoSitePlus
S505TSYPLsPLSDFMAPK14HPRD
Y456DAGSDyQSDNQPLA2_BPhosphoSitePlus
S505TSYPLsPLSDFErk2(MAPK1RegPhos
S515FATQDsFDDDEHPRD
S727NPSRCsVSLSNMKNK1HPRD
S505TSYPLsPLSDFMAPK_groupphosphoELM; RegPhos
Y535EFERIyEPLDVHPRD; phosphoELM
T512LSDFAtQDSFDHPRD
S437NDSSDsDDESHPLA2_BPhosphoSitePlus
T21YSHKFtVVVLRC2PhosphoSitePlus
S435VSNDSsDSDDEHPRD; phosphoELM
Y359IGMAKyGTFMAPLA2_BPhosphoSitePlus
S505TSYPLsPLSDFMAPK1phosphoELM
S505TSYPLsPLSDFPLA2_BPhosphoSitePlus
S441DSDDEsHEPKGHPRD
S505TSYPLsPLSDFp38aRegPhos
T21YSHKFtVVVLRHPRD
S454NEDAGsDYQSDHPRD; phosphoELM; RegPhos
S515FATQDsFDDDEPLA2_BPhosphoSitePlus
S727NPSRCsVSLSNPhosphoSitePlus; phosphoELM; RegPhos
T268PLLLLtPQKVKHPRD; phosphoELM
S727NPSRCsVSLSNMAPKAPK5HPRD; RegPhos
S434IVSNDsSDSDDPLA2_BPhosphoSitePlus
S178LGPKNsEGLHSPhosphoSitePlus; HPRD
S515FATQDsFDDDECaMK2aRegPhos
S727NPSRCsVSLSNMSK1RegPhos
S431TKHIVsNDSSDPLA2_BPhosphoSitePlus
S515FATQDsFDDDECaM-KII_alphaphosphoELM
S437NDSSDsDDESHHPRD; phosphoELM; RegPhos
S505TSYPLsPLSDFHPRD; phosphoELM; RegPhos
S183SEGLHsARDVPPhosphoSitePlus
S228YVAGLsGSTWYphosphoELM; RegPhos
S228YVAGLsGSTWYPLA2_BPhosphoSitePlus
S508PLSPLsDFATQHPRD
S434IVSNDsSDSDDHPRD; phosphoELM
S431TKHIVsNDSSDHPRD; phosphoELM; RegPhos
S463SDNQAsWIHRMPLA2_BPhosphoSitePlus
T268PLLLLtPQKVKPLA2_BPhosphoSitePlus
Y535EFERIyEPLDVPLA2_BPhosphoSitePlus
S727NPSRCsVSLSNMNK1RegPhos

Dephosphorylation site
PA24A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356436V70ECOSMICLung Cancer20668451
ENSP00000356436K155NCOSMICLung Cancer20668451
ENSP00000356436L744VBIOMARTBreast Cancer21930507, 21930502
ENSP00000356436H442QSjoblom2006, HPIBreast Cancer16959974, 21720365, 18772890
ENSP00000356436P288LCOSMICSkin Cancer21984974
ENSP00000356436H442QTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000356436A597TBIOMARTGastric Cancer21930507, 21930502

Differential expressed protein
PA24A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PA24A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANPA24A_HUMANkinase -> substrateHPRD
KS6A5_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
MKNK1_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
MK01_HUMANPA24A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANPA24A_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04726Serotonergic synapse
hsa01100Metabolic pathways
hsa00590Arachidonic acid metabolism
hsa04975Fat digestion and absorption
hsa00592alpha-Linolenic acid metabolism
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa00591Linoleic acid metabolism
hsa00565Ether lipid metabolism
hsa04724Glutamatergic synapse
hsa04664Fc epsilon RI signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa00564Glycerophospholipid metabolism
hsa04666Fc gamma R-mediated phagocytosis
hsa04972Pancreatic secretion
hsa04010MAPK signaling pathway
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071236cellular response to antibioticIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0005743mitochondrial inner membraneTAScellular_component
GO:0004620phospholipase activityIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0006654phosphatidic acid biosynthetic processTASbiological_process
GO:0036150phosphatidylserine acyl-chain remodelingTASbiological_process
GO:0036149phosphatidylinositol acyl-chain remodelingTASbiological_process
GO:0036152phosphatidylethanolamine acyl-chain remodelingTASbiological_process
GO:0006690icosanoid metabolic processNASbiological_process
GO:0004622lysophospholipase activityIEAmolecular_function
GO:0005544calcium-dependent phospholipid bindingIDAmolecular_function
GO:0008152metabolic processIEAbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0035965cardiolipin acyl-chain remodelingTASbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0046456icosanoid biosynthetic processIEAbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0009395phospholipid catabolic processIEAbiological_process
GO:0005829cytosolNAScellular_component
GO:0036151phosphatidylcholine acyl-chain remodelingTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0004623phospholipase A2 activityNASmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0046474glycerophospholipid biosynthetic processTASbiological_process
GO:0036148phosphatidylglycerol acyl-chain remodelingTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0050482arachidonic acid secretionIEAbiological_process
GO:0016787hydrolase activityTASmolecular_function
GO:0006663platelet activating factor biosynthetic processNASbiological_process
GO:0044281small molecule metabolic processTASbiological_process


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