Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:P85A_HUMAN
Description:phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [Source:HGNC Symbol;Acc:8979]
Location:chr5 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y337NTEDQySLVEDINSRHPRD
Y607NTEDQySLVEDInsRRegPhos; SysPTM
Y310KTRDQyLMWLTINSRHPRD
Y688EPYNLySSLKEphosphoELM; RegPhos
S83GRKKIsPPTPKPhosphoSitePlus
S608TEDQYsLVEDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y528RIMHNyDKLKSIncA; DUF1338PhosphoSitePlus
Y580KTRDQyLMWLTINSRHPRD; phosphoELM; RegPhos
Y688EPYNLySSLKELCKHPRD; RegPhos
Y12QYRALyDYKKESH3_2PhosphoSitePlus
T490EAFNEtIKIFEIncA; DUF1338PhosphoSitePlus
Y167EYDRLyEEYTRHPRD
Y368KMHGDyTLTLRSH2PhosphoSitePlus
T369MHGDYtLTLRKSH2PhosphoSitePlus
Y197EYDRLyEEYTRHPRD
Y607NTEDQySLVEDDUF1338PhosphoSitePlus; SysPTM
Y452KKLHEyNTQFQHPRD; phosphoELM
Y68KMHGDyTLTLRHPRD
Y368KMHGDyTLTLRInsRRegPhos
Y59GWLNGyNETTGSH3_2PhosphoSitePlus
S328TWNVGsSNRNKHPRD
Y467EYDRLyEEYTRIncA; DUF1338PhosphoSitePlus
Y76GTYVEyIGRKKSH3_2PhosphoSitePlus
Y418EPYNLySSLKELCKHPRD
Y73DFPGTyVEYIGSH3_2PhosphoSitePlus
T603LGNENtEDQYSDUF1338PhosphoSitePlus
Y426DVKLLyPVSKYIncAPhosphoSitePlus
Y98KMHGDyTLTLRHPRD
T454LHEYNtQFQEKIncA; DUF1338PhosphoSitePlus
Y679KTATGyGFAEPSH2PhosphoSitePlus
Y657SKQGCyACSVVSH2PhosphoSitePlus
Y556KQAAEyREIDKIncA; DUF1338PhosphoSitePlus
S329WNVGSsNRNKAHPRD
Y307NTEDQySLVEDINSRHPRD
Y580KTRDQyLMWLTDUF1338PhosphoSitePlus
S359WNVGSsNRNKAHPRD
Y98KMHGDyTLTLRINSRHPRD
T576IQLRKtRDQYLDUF1338PhosphoSitePlus
Y280KTRDQyLMWLTINSRHPRD
Y388EPYNLySSLKELCKHPRD
Y152KKLHEyNTQFQHPRD
S265NARVLsEIFSPRhoGAPPhosphoSitePlus
S629WNVGSsNRNKAHPRD
Y286KQAAEyREIDKHPRD
Y203IPAAVySEMISRhoGAPPhosphoSitePlus
Y607NTEDQySLVEDSRCphosphoELM; SysPTM
Y368KMHGDyTLTLRHPRD; RegPhos
S338TEDQYsLVEDDHPRD
Y556KQAAEyREIDKHPRD; phosphoELM
Y508RYSKEyIEKFKIncA; DUF1338PhosphoSitePlus
Y580KTRDQyLMWLTInsRRegPhos
S147KGLECsTLYRTRhoGAPPhosphoSitePlus
Y607NTEDQySLVEDphosphoELM; RegPhos; SysPTM
S628TWNVGsSNRNKHPRD
T623HHDEKtWNVGSphosphoELM; RegPhos
Y607NTEDQySLVEDINSRHPRD; phosphoELM; RegPhos; SysPTM
Y368KMHGDyTLTLRINSRHPRD; phosphoELM; RegPhos
T152STLYRtQSSSNRhoGAPPhosphoSitePlus
S608TEDQYsLVEDDPIK3CAphosphoELM; RegPhos
T471LYEEYtRTSQEIncA; DUF1338PhosphoSitePlus
Y256KQAAEyREIDKHPRD
Y452KKLHEyNTQFQIncA; DUF1338PhosphoSitePlus
Y470RLYEEyTRTSQIncA; DUF1338PhosphoSitePlus
Y580KTRDQyLMWLTphosphoELM
Y504QTQERySKEYIIncA; DUF1338PhosphoSitePlus
Y688EPYNLySSLKESH2PhosphoSitePlus
Y467EYDRLyEEYTRHPRD; phosphoELM; RegPhos
Y68KMHGDyTLTLRINSRHPRD
S358TWNVGsSNRNKHPRD
S308TEDQYsLVEDDHPRD
Y182KKLHEyNTQFQHPRD
T148GLECStLYRTQRhoGAPPhosphoSitePlus
S154LYRTQsSSNLARhoGAPPhosphoSitePlus
Y607NTEDQySLVEDSrcRegPhos; SysPTM
Y463EKSREyDRLYEIncA; DUF1338PhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S308ENTEDQYsLVEDDEDPPM1AHPRD
S338ENTEDQYsLVEDDEDPPM1AHPRD
S608ENTEDQYsLVEDDEDPPM1AHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000274335R358*COSMICUterine Cancer21478295
ENSP00000429277R358*COSMICUterine Cancer21478295
ENSP00000429277G71*COSMICLung Cancer
ENSP00000274335N564KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000429277N527KCOSMICIntestines Cancer19962665
ENSP00000428056N527KCOSMICIntestines Cancer19962665
ENSP00000274335R649QCOSMICIntestines Cancer19962665
ENSP00000429277D560YCOSMICCentral Nervous System Neoplasms18772890
ENSP00000274335R348*COSMICIntestines Cancer19962665
ENSP00000428056D13VBIOMARTBreast Cancer21930507, 21930502
ENSP00000428056Y334*COSMICUterine Cancer21478295
ENSP00000428056R348*COSMICIntestines Cancer19962665
ENSP00000274335L570PCOSMICUterine Cancer21984976
ENSP00000429277D464HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000428056D560YCOSMICCentral Nervous System Neoplasms18772890
ENSP00000274335R642*COSMICIntestines Cancer19962665
ENSP00000428056E666KCOSMICIntestines Cancer19962665
ENSP00000274335E666KCOSMICIntestines Cancer19962665
ENSP00000429277L570PCOSMICUterine Cancer21984976
ENSP00000429277K567ECOSMICUterine Cancer21984976
ENSP00000274335D13VBIOMARTBreast Cancer21930507, 21930502
ENSP00000428056R543ICOSMICIntestines Cancer19962665
ENSP00000429277I290VCOSMICHead and Neck Cancer21798893
ENSP00000274335R301*COSMICUterine Cancer21478295
ENSP00000428056R642*COSMICIntestines Cancer19962665
ENSP00000428056R639*COSMICUterine Cancer21984976
ENSP00000428056A682VCOSMICIntestines Cancer19962665
ENSP00000274335D548GCOSMICUterine Cancer21478295
ENSP00000428056G376RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000428056R574TCOSMICOther Cancer21533174
ENSP00000274335R386GCOSMICUterine Cancer21984976
ENSP00000428056R358*COSMICUterine Cancer21478295
ENSP00000274335G376RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000274335D560YCOSMICCentral Nervous System Neoplasms18772890
ENSP00000274335K459ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000428056K459ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000274335N260SCOSMICUterine Cancer21984976
ENSP00000429277A634PCOSMICBreast Cancer20668451
ENSP00000428056L570PCOSMICUterine Cancer21984976
ENSP00000274335A634PCOSMICBreast Cancer20668451
ENSP00000429277N260SCOSMICUterine Cancer21984976
ENSP00000429277R348*COSMICIntestines Cancer19962665
ENSP00000274335Y334*COSMICUterine Cancer21478295
ENSP00000274335K567ECOSMICUterine Cancer21984976
ENSP00000428056N260SCOSMICUterine Cancer21984976
ENSP00000429277D548GCOSMICUterine Cancer21478295
ENSP00000428056R461*COSMICIntestines Cancer
ENSP00000274335R162*COSMICIntestines Cancer19962665
ENSP00000274335N285HCOSMICIntestines Cancer19962665
ENSP00000274335R461*COSMICIntestines Cancer
ENSP00000429277D13VBIOMARTBreast Cancer21930507, 21930502
ENSP00000428056R649QCOSMICIntestines Cancer19962665
ENSP00000274335T473SCOSMICUterine Cancer21984976
ENSP00000429277N285HCOSMICIntestines Cancer19962665
ENSP00000429277R386GCOSMICUterine Cancer21984976
ENSP00000428056N285HCOSMICIntestines Cancer19962665
ENSP00000274335R574TCOSMICOther Cancer21533174
ENSP00000429277Y334*COSMICUterine Cancer21478295
ENSP00000274335D464HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000429277N564KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000429277E666KCOSMICIntestines Cancer19962665
ENSP00000429277G376RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000429277K459ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000429277L449SCOSMICBreast Cancer19962665
ENSP00000429277R642*COSMICIntestines Cancer19962665
ENSP00000274335I290VCOSMICHead and Neck Cancer21798893
ENSP00000274335L449SCOSMICBreast Cancer19962665
ENSP00000428056A634PCOSMICBreast Cancer20668451
ENSP00000274335K448fs*32COSMICLymphoma
ENSP00000429277R301*COSMICUterine Cancer21478295
ENSP00000274335N527KCOSMICIntestines Cancer19962665
ENSP00000429277E495*COSMICUterine Cancer21478295
ENSP00000429277R543ICOSMICIntestines Cancer19962665
ENSP00000428056R162*COSMICIntestines Cancer19962665
ENSP00000428056T473SCOSMICUterine Cancer21984976
ENSP00000274335G71*COSMICLung Cancer
ENSP00000274335C498*COSMICUterine Cancer21478295
ENSP00000429277R574TCOSMICOther Cancer21533174
ENSP00000379855D13VBIOMARTBreast Cancer21930507, 21930502
ENSP00000428056K448fs*32COSMICLymphoma
ENSP00000429277R649QCOSMICIntestines Cancer19962665
ENSP00000274335E495*COSMICUterine Cancer21478295
ENSP00000429277K448fs*32COSMICLymphoma
ENSP00000428056C498*COSMICUterine Cancer21478295
ENSP00000428056R301*COSMICUterine Cancer21478295
ENSP00000429277T473SCOSMICUterine Cancer21984976
ENSP00000429277A682VCOSMICIntestines Cancer19962665
ENSP00000274335A682VCOSMICIntestines Cancer19962665
ENSP00000428056G71*COSMICLung Cancer
ENSP00000429277R162*COSMICIntestines Cancer19962665
ENSP00000428056D464HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000429277R639*COSMICUterine Cancer21984976
ENSP00000428056N564KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000428056D548GCOSMICUterine Cancer21478295
ENSP00000429277C498*COSMICUterine Cancer21478295
ENSP00000274335R639*COSMICUterine Cancer21984976
ENSP00000428056I290VCOSMICHead and Neck Cancer21798893
ENSP00000428056R386GCOSMICUterine Cancer21984976
ENSP00000274335R543ICOSMICIntestines Cancer19962665
ENSP00000428056E495*COSMICUterine Cancer21478295
ENSP00000428056L449SCOSMICBreast Cancer19962665
ENSP00000428056K567ECOSMICUterine Cancer21984976
ENSP00000429277R461*COSMICIntestines Cancer

Differential expressed protein
P85A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
P85A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANP85A_HUMANkinase -> substrateRegPhos
LCK_HUMANP85A_HUMANkinase -> substrateHPRD; RegPhos; NetPath
KIT_HUMANP85A_HUMANkinase -> substrateNetPath
FYN_HUMANP85A_HUMANkinase -> substrateNetPath
IL2RG_HUMANP85A_HUMANkinase -> substrateNetPath
INSR_HUMANP85A_HUMANkinase -> substrateRegPhos
PK3CA_HUMANP85A_HUMANkinase -> substrateRegPhos
P85A_HUMANAKT1_HUMANkinase -> substrateNetPath
PPM1A_HUMANP85A_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa05222Small cell lung cancer
hsa04722Neurotrophin signaling pathway
hsa04662B cell receptor signaling pathway
hsa05210Colorectal cancer
hsa05203Viral carcinogenesis
hsa04664Fc epsilon RI signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa05162Measles
hsa04660T cell receptor signaling pathway
hsa05220Chronic myeloid leukemia
hsa04910Insulin signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04725Cholinergic synapse
hsa05218Melanoma
hsa05100Bacterial invasion of epithelial cells
hsa05146Amoebiasis
hsa05214Glioma
hsa04370VEGF signaling pathway
hsa04210Apoptosis
hsa04930Type II diabetes mellitus
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04150mTOR signaling pathway
hsa05221Acute myeloid leukemia
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05212Pancreatic cancer
hsa04670Leukocyte transendothelial migration
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05160Hepatitis C
hsa05223Non-small cell lung cancer
hsa04630Jak-STAT signaling pathway
hsa04012ErbB signaling pathway
hsa04973Carbohydrate digestion and absorption
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa05164Influenza A
hsa04914Progesterone-mediated oocyte maturation
hsa05211Renal cell carcinoma
hsa04650Natural killer cell mediated cytotoxicity
hsa04666Fc gamma R-mediated phagocytosis
hsa05169Epstein-Barr virus infection
hsa04810Regulation of actin cytoskeleton

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043560insulin receptor substrate bindingIEAmolecular_function
GO:0050900leukocyte migrationTASbiological_process
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005158insulin receptor bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030183B cell differentiationIEAbiological_process
GO:0043551regulation of phosphatidylinositol 3-kinase activiISSbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007596blood coagulationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005829cytosolTAScellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0008286insulin receptor signaling pathwayIPIbiological_process
GO:0045671negative regulation of osteoclast differentiationIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0034644cellular response to UVIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0046326positive regulation of glucose importISSbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0051531NFAT protein import into nucleusIEAbiological_process
GO:0019903protein phosphatase bindingIPImolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, classISScellular_component
GO:0048009insulin-like growth factor receptor signaling pathIPIbiological_process
GO:0005942phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0035014phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043125ErbB-3 class receptor bindingIDAmolecular_function
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:00055451-phosphatidylinositol bindingNASmolecular_function
GO:0001953negative regulation of cell-matrix adhesionIEAbiological_process
GO:0046854phosphatidylinositol phosphorylationISSbiological_process
GO:0090004positive regulation of establishment of protein loISSbiological_process
GO:0043559insulin bindingIDAmolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005168neurotrophin TRKA receptor bindingIPImolecular_function
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0005068transmembrane receptor protein tyrosine kinase adaISSmolecular_function
GO:0043548phosphatidylinositol 3-kinase bindingISSmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0014065phosphatidylinositol 3-kinase cascadeIDAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process