Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OSTP_HUMAN
Description:secreted phosphoprotein 1 [Source:HGNC Symbol;Acc:11255]
Location:chr4 q22.1
Node attribute:substrate; ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S27ADSGSsEEKQLOsteopontinPhosphoSitePlus
S311LDSASsEVN__OsteopontinPhosphoSitePlus
S191DEDITsHMESEHPRD; RegPhos
S308SHELDsASSEVRegPhos
S62PQNAVsSEETNOsteopontinPhosphoSitePlus
S195TSHMEsEELNGHPRD; RegPhos
S123HQSDEsHHSDEOsteopontinPhosphoSitePlus
S81SKSNEsHDHMDRegPhos
T213KDSYEtSQLDDHPRD
S254KANDEsNEHSDOsteopontinPhosphoSitePlus
S267DSQELsKVSREHPRD; RegPhos
S311LDSASsEHPRD
S219PSDWDsRGKDSHPRD; RegPhos
S231ESNEHsDVIDSHPRD
S234QLDDQsAETHSOsteopontinPhosphoSitePlus
S297LDSASsEHPRD
T66VSSEEtNDFKQOsteopontinPhosphoSitePlus
S227KANDEsNEHSDHPRD
S267DSQELsKVSREOsteopontinPhosphoSitePlus
S24VKQADsGSSEEOsteopontinPhosphoSitePlus
T185QYPDAtDEDITOsteopontinPhosphoSitePlus
S26QADSGsSEEKQRegPhos
S263SDVIDsQELSKOsteopontinPhosphoSitePlus
S280SHEFHsHEDMLHPRD; RegPhos
S99DDHVDsQDSIDRegPhos
S129HHSDEsDELVTOsteopontinPhosphoSitePlus
S99DDHVDsQDSIDOsteopontinPhosphoSitePlus
S129HHSDEsDELVTRegPhos
S215DLNAPsDWDSROsteopontinPhosphoSitePlus
T66VSSEEtNDFKQRegPhos
Y225RGKDSyETSQLHPRD
S283ELDSAsSEHPRD
S263SDVIDsQELSKHPRD; RegPhos
S284LDSASsEHPRD
T158QYPDAtDEDITHPRD
T185QYPDAtDEDITHPRD; RegPhos
S236SDVIDsQELSKHPRD
S148DGRGDsVVYGLCSNK2A2HPRD
S148DGRGDsVVYGLCSNK2A1HPRD
S244ESNEHsDVIDSHPRD
S275SREFHsHEFHSHPRD; RegPhos
S224SRGKDsYETSQHPRD; RegPhos
S162DGRGDsVVYGLCK2a1RegPhos
S197SRGKDsYETSQHPRD
S62PQNAVsSEETNHPRD; RegPhos
S24VKQADsGSSEEHPRD; RegPhos
S76QETLPsKSNESOsteopontinPhosphoSitePlus
S310ELDSAsSEVNRegPhos
S253DSQELsKVSREHPRD
S270ELSKVsREFHSHPRD
S177DEDITsHMESEHPRD
T147ATEVFtPVVPTOsteopontinPhosphoSitePlus
S308SHELDsASSEHPRD
S105QDSIDsNDSDDRegPhos
S126DESHHsDESDEOsteopontinPhosphoSitePlus
S162DGRGDsVVYGLPKCaRegPhos
S63QNAVSsEETNDHPRD; RegPhos
T152TPVVPtVDTYDOsteopontinPhosphoSitePlus
S207QLDDQsAETHSHPRD
S148DGRGDsVVYGLPRKCAHPRD
S120DDSHQsDESHHOsteopontinPhosphoSitePlus
S266SHEFHsHEDMLHPRD
S289LKFRIsHELDSHPRD
S303LKFRIsHELDSHPRD; RegPhos
S168TSHMEsEELNGHPRD
S195TSHMEsEELNGOsteopontinPhosphoSitePlus
S240KANDEsNEHSDHPRD
S256ELSKVsREFHSHPRD
S248SREFHsHEFHSHPRD
S261SREFHsHEFHSHPRD
S210SRGKDsYETSQHPRD
S117DDTDDsHQSDERegPhos
S308SHELDsASSEVOsteopontinPhosphoSitePlus
S126DESHHsDESDERegPhos
S162DGRGDsVVYGLPKG1RegPhos
S78TLPSKsNESHDOsteopontinPhosphoSitePlus
S81SKSNEsHDHMDOsteopontinPhosphoSitePlus
T223DQSAEtHSHKQHPRD
T210DQSAEtHSHKQHPRD
T143TDLPAtEVFTPOsteopontinPhosphoSitePlus
S281SHELDsASSEHPRD
S214DSYETsQLDDQHPRD
S275SREFHsHEFHSOsteopontinPhosphoSitePlus
S310ELDSAsSEVN_OsteopontinPhosphoSitePlus
T134SDELVtDFPTDOsteopontinPhosphoSitePlus
S188DLNAPsDWDSRHPRD
S296ELDSAsSEHPRD
S181TSHMEsEELNGHPRD
S220QLDDQsAETHSHPRD
S148DGRGDsVVYGLPRKG1HPRD
S270ELSKVsREFHSOsteopontinPhosphoSitePlus
S240DSQELsKVSREHPRD
S219PSDWDsRGKDSOsteopontinPhosphoSitePlus
S253SHEFHsHEDMLHPRD
S205PSDWDsRGKDSHPRD
Y198RGKDSyETSQLHPRD
S303LKFRIsHELDSOsteopontinPhosphoSitePlus
S258ESNEHsDVIDSHPRD
S243ELSKVsREFHSHPRD
S258ESNEHsDVIDSOsteopontinPhosphoSitePlus
S215DLNAPsDWDSRHPRD; RegPhos
S117DDTDDsHQSDEOsteopontinPhosphoSitePlus
S102VDSQDsIDSNDRegPhos
S164DEDITsHMESEHPRD
S224SRGKDsYETSQOsteopontinPhosphoSitePlus
T171QYPDAtDEDITHPRD
S191DEDITsHMESEOsteopontinPhosphoSitePlus
S102VDSQDsIDSNDOsteopontinPhosphoSitePlus
Y211RGKDSyETSQLHPRD
S192PSDWDsRGKDSHPRD
T138VTDFPtDLPATOsteopontinPhosphoSitePlus
S27ADSGSsEEKQLRegPhos
T237DQSAEtHSHKQHPRD
S294SHELDsASSEHPRD
S76QETLPsKSNESRegPhos
S162DGRGDsVVYGLCK2a1-rsRegPhos
S162DGRGDsVVYGLCK2a2RegPhos
S105QDSIDsNDSDDOsteopontinPhosphoSitePlus
S234QLDDQsAETHSHPRD; RegPhos
S228DSYETsQLDDQOsteopontinPhosphoSitePlus
S201DLNAPsDWDSRHPRD
T200KDSYEtSQLDDHPRD
S123HQSDEsHHSDERegPhos
S310ELDSAsSEHPRD
S276LKFRIsHELDSHPRD
S228DSYETsQLDDQHPRD; RegPhos
S120DDSHQsDESHHRegPhos
S201DSYETsQLDDQHPRD
S291VVDPKsKEEDKOsteopontinPhosphoSitePlus
S26QADSGsSEEKQOsteopontinPhosphoSitePlus
S249SDVIDsQELSKHPRD
S108IDSNDsDDVDDRegPhos
S63QNAVSsEETNDOsteopontinPhosphoSitePlus
S108IDSNDsDDVDDOsteopontinPhosphoSitePlus
S280SHEFHsHEDMLOsteopontinPhosphoSitePlus
T227KDSYEtSQLDDHPRD
S254KANDEsNEHSDHPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S148TYDGRGDsVVYGLRSACP5HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378517Q229KCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378517Brain CancerNormal vs. CancertissueUp2.518056677
ENSP00000378517Brain CancerNormal vs. CancertissueUp418056677

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S117OsteopontinDVDDTDDsHQSDESHX-linked hypophosphatemia19775205PhosphoSitePlus
S126OsteopontinQSDESHHsDESDELVX-linked hypophosphatemia19775205PhosphoSitePlus
S120OsteopontinDTDDSHQsDESHHSDX-linked hypophosphatemia19775205PhosphoSitePlus
S123OsteopontinDSHQSDEsHHSDESDX-linked hypophosphatemia19775205PhosphoSitePlus
S129OsteopontinESHHSDEsDELVTDFX-linked hypophosphatemia19775205PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
OSTP_HUMANITAV_HUMANligand -> receptorHPMR
OSTP_HUMANCD44_HUMANligand -> receptorHPMR
CSK22_HUMANOSTP_HUMANkinase -> substrateHPRD
CSK21_HUMANOSTP_HUMANkinase -> substrateHPRD
KPCA_HUMANOSTP_HUMANkinase -> substrateHPRD
ZAGL2_HUMANOSTP_HUMANkinase -> substrateRegPhos
KGP1_HUMANOSTP_HUMANkinase -> substrateHPRD
PPA5_HUMANOSTP_HUMANphosphatase -> substrateHPRD
OSTP_HUMANIRF7_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04512ECM-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007566embryo implantationTASbiological_process
GO:0046697decidualizationTASbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0031214biomineral tissue developmentIEAbiological_process
GO:0010811positive regulation of cell-substrate adhesionIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0048545response to steroid hormone stimulusIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0050840extracellular matrix bindingIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0031988membrane-bounded vesicleIEAcellular_component
GO:0042995cell projectionIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0005615extracellular spaceIDAcellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0005125cytokine activityIEAmolecular_function
GO:0033280response to vitamin DIDAbiological_process
GO:0048685negative regulation of collateral sprouting of intIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0007155cell adhesionIEAbiological_process


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