| UniProt/SwissProt ID: | OPRK_HUMAN |
| Description: | opioid receptor, kappa 1 [Source:HGNC Symbol;Acc:8154] |
| Location: | chr8 q11.23 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S260 | SVRLLsGSREK | 7tm_1 | PhosphoSitePlus |
| S358 | ERQSTsRVRNT | PhosphoSitePlus | |
| S262 | RLLSGsREKDR | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| OPRK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000429706 | S78T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265572 | S186L | COSMIC | Melanoma | 21499247 | ENSP00000265572 | C345R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000429706 | R252H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265572 | S78T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000265572 | R252H | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| OPRK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OPRK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PDYN_HUMAN | OPRK_HUMAN | ligand -> receptor | HPMR |
| COLI_HUMAN | OPRK_HUMAN | ligand -> receptor | HPMR |
| OPRK_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| OPRK_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| OPRK_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| OPRK_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006955 | immune response | IDA | biological_process |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007610 | behavior | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0038048 | dynorphin receptor activity | IEA | molecular_function |
| GO:0038003 | opioid receptor signaling pathway | IDA | biological_process |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0007600 | sensory perception | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0051607 | defense response to virus | IDA | biological_process |