Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ODPA_HUMAN
Description:pyruvate dehydrogenase (lipoamide) alpha 1 [Source:HGNC Symbol;Acc:8806]
Location:chrX p22.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T303GVSYRtREEIQE1_dhPhosphoSitePlus
T240RAAAStDYYKRE1_dhPhosphoSitePlus
S293RYHGHsMSDPGPDHK3phosphoELM; RegPhos
S293RYHGHsMSDPGPDHK1phosphoELM; RegPhos
S293RYHGHsMSDPGPDHK2phosphoELM; RegPhos
S293RYHGHsMSDPGPDHK4phosphoELM; RegPhos
S295HGHSMsDPGVSE1_dhPhosphoSitePlus
S300SDPGVsYRTREPDHK3phosphoELM; RegPhos
Y272RFAAAyCRSGKE1_dhPhosphoSitePlus
S232YGMGTsVERAAE1_dhPhosphoSitePlus; SysPTM
Y366LEELGyHIYSSPhosphoSitePlus
T116TDHLItAYRAHE1_dhPhosphoSitePlus
Y242AASTDyYKRGDE1_dhPhosphoSitePlus
T231RYGMGtSVERAHPRD; phosphoELM
S300SDPGVsYRTREphosphoELM; RegPhos
S300SDPGVsYRTREPDK1HPRD
S300SDPGVsYRTREPDK2HPRD
S300SDPGVsYRTREPDK4HPRD
Y369LGYHIySSDPPHPRD
S300SDPGVsYRTREPDHK2phosphoELM; RegPhos
S300SDPGVsYRTREPDHK1phosphoELM; RegPhos
S300SDPGVsYRTREPDHK4phosphoELM; RegPhos
S232YGMGTsVERAAPDHK1RegPhos; SysPTM
S232YGMGTsVERAAPDHK3RegPhos; SysPTM
S295HGHSMsDPGVSHPRD; phosphoELM; RegPhos
S232YGMGTsVERAAPDK1HPRD; SysPTM
S232YGMGTsVERAAPDK3HPRD; SysPTM
Y118HLITAyRAHGFE1_dhPhosphoSitePlus
Y289LQTYRyHGHSMHPRD; phosphoELM; RegPhos
S293RYHGHsMSDPGPDK4HPRD
S293RYHGHsMSDPGPDK3HPRD
S293RYHGHsMSDPGPDK1HPRD
Y227CENNRyGMGTSE1_dhPhosphoSitePlus
Y227CENNRyGMGTSHPRD
S293RYHGHsMSDPGphosphoELM; RegPhos
Y243ASTDYyKRGDFE1_dhPhosphoSitePlus
Y301DPGVSyRTREEHPRD; phosphoELM; RegPhos
S152KGKGGsMHMYAE1_dhPhosphoSitePlus
S232YGMGTsVERAAHPRD; phosphoELM; RegPhos; SysPTM
S293RYHGHsMSDPGPDK2HPRD
Y301DPGVSyRTREEE1_dhPhosphoSitePlus
Y289LQTYRyHGHSME1_dhPhosphoSitePlus
S300SDPGVsYRTREE1_dhPhosphoSitePlus
S293RYHGHsMSDPGE1_dhPhosphoSitePlus
T231RYGMGtSVERAE1_dhPhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S232NRYGMGTsVERAAASPDP1HPRD
S293TYRYHGHsMSDPGVSPDP1HPRD
S300SMSDPGVsYRTREEIPDP1HPRD

Mutation site
ODPA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000440761Breast CancerTreatment (none vs. SEL1L treatment)cell lineDown0.3215880780
ENSP00000440761Breast CancerNormal vs. CancertissueDown0.4720739354

Hyperphosphorylation site
ODPA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDK3_HUMANODPA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PDK4_HUMANODPA_HUMANkinase -> substrateRegPhos
PDK2_HUMANODPA_HUMANkinase -> substrateRegPhos
PDPK1_HUMANODPA_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PDK1_HUMANODPA_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANODPA_HUMANkinase -> substrateRegPhos
PDP1_HUMANODPA_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00010Glycolysis / Gluconeogenesis
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00650Butanoate metabolism
hsa00020Citrate cycle (TCA cycle)
hsa00620Pyruvate metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006090pyruvate metabolic processTASbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0006086acetyl-CoA biosynthetic process from pyruvateIDAbiological_process
GO:0005759mitochondrial matrixTAScellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0010510regulation of acetyl-CoA biosynthetic process fromTASbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0006096glycolysisIEAbiological_process
GO:0004739pyruvate dehydrogenase (acetyl-transferring) activIEAmolecular_function
GO:0004738pyruvate dehydrogenase activityIEAmolecular_function
GO:0055114oxidation-reduction processIEAbiological_process
GO:0006099tricarboxylic acid cycleIDAbiological_process
GO:0045254pyruvate dehydrogenase complexIDAcellular_component
GO:0016624oxidoreductase activity, acting on the aldehyde orIEAmolecular_function


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