| UniProt/SwissProt ID: | PDP1_HUMAN |
| Description: | pyruvate dehyrogenase phosphatase catalytic subunit 1 [Source:HGNC Symbol;Acc:9279] |
| Location: | chr8 q22.1 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y46 | QSRLRyTPHPA | PhosphoSitePlus | |
| Dephosphorylation site |
| PDP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000428317 | D231H | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000297598 | D231H | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000428317 | T23I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000297598 | I518S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000428317 | I518S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000428317 | G141R | COSMIC | Melanoma | 21499247 | ENSP00000430380 | D231H | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000430380 | I518S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000430380 | T23I | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000297598 | G141R | COSMIC | Melanoma | 21499247 | ENSP00000430380 | G141R | COSMIC | Melanoma | 21499247 | ENSP00000297598 | T23I | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| PDP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PDP1_HUMAN | ODPA_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PDP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0010510 | regulation of acetyl-CoA biosynthetic process from | TAS | biological_process |
| GO:0004722 | protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0006090 | pyruvate metabolic process | TAS | biological_process |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase a | IEA | molecular_function |
| GO:0035970 | peptidyl-threonine dephosphorylation | IDA | biological_process |