Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NUCL_HUMAN
Description:nucleolin [Source:HGNC Symbol;Acc:7667]
Location:chr2 q37.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T405LPYKVtQDELKRRM_1PhosphoSitePlus
S609RETGSsKGFGFRRM_1PhosphoSitePlus
T304EGTEPtTAFNLPhosphoSitePlus; HPRD
T92KKAAAtPAKKTPhosphoSitePlus; HPRD
S184AAAPAsEDEDDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S580FVKGLsEDTTERRM_1PhosphoSitePlus
T606VTDREtGSSKGRRM_1PhosphoSitePlus
S145AKKEDsDEEEDPhosphoSitePlus; HPRD; phosphoELM
S608DRETGsSKGFGRRM_1PhosphoSitePlus
T121KALVAtPGKKGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T214EAMETtPAKGKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y473GQNQDyRGGKNPhosphoSitePlus
S619FVDFNsEEDAKRRM_1PhosphoSitePlus; SysPTM
S67KKVVVsPTKKVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S580FVKGLsEDTTEHPRD; phosphoELM
T641DGNKVtLDWAKRRM_1PhosphoSitePlus
S28EVEEDsEDEEMPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T367KALELtGLKVFRRM_1PhosphoSitePlus
S595ESFDGsVRARIHPRD
T113GKKGAtPGKALPhosphoSitePlus; HPRD
T707PQGKKtKFE__PhosphoSitePlus
S153EEDDDsEEDEEPhosphoSitePlus; HPRD; phosphoELM
Y525GKSKGyAFIEFRRM_1PhosphoSitePlus
T405LPYKVtQDELKHPRD
S542KEALNsCNKRERRM_1PhosphoSitePlus
Y463SISLYyTGEKGPhosphoSitePlus
S496SNLSYsATEETHPRD
S460DGRSIsLYYTGRRM_1PhosphoSitePlus
Y402AKNLPyKVTQDRRM_1PhosphoSitePlus
S206DEEDDsEEEAMPhosphoSitePlus; HPRD; phosphoELM
T480GGKNStWSGESPhosphoSitePlus
T498LSYSAtEETLQRRM_1PhosphoSitePlus
T367KALELtGLKVFHPRD; phosphoELM
S458EIDGRsISLYYHPRD
T97TPAKKtVTPAKPhosphoSitePlus; HPRD
T602RARIVtDRETGRRM_1PhosphoSitePlus
T498LSYSAtEETLQHPRD
S458EIDGRsISLYYRRM_1PhosphoSitePlus
Y351TRKFGyVDFESRRM_1PhosphoSitePlus
S423EIRLVsKDGKSRRM_1PhosphoSitePlus
T487SGESKtLVLSNPhosphoSitePlus
T84KKAAVtPGKKAPhosphoSitePlus; HPRD
T99AKKTVtPAKAVPhosphoSitePlus; HPRD; phosphoELM
S356YVDFEsAEDLERRM_1PhosphoSitePlus
S34EDEEMsEDEEDPhosphoSitePlus; HPRD; phosphoELM
S428SKDGKsKGIAYRRM_1PhosphoSitePlus
S532FIEFAsFEDAKRRM_1PhosphoSitePlus
T69VVVSPtKKVAVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S563QGPRGsPNARSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T305GTEPTtAFNLFPhosphoSitePlus; HPRD
Y462RSISLyYTGEKPhosphoSitePlus
T105PAKAVtTPGKKPhosphoSitePlus; HPRD; phosphoELM
S41DEEDDsSGEEVPhosphoSitePlus; HPRD; phosphoELM
S619FVDFNsEEDAKHPRD; phosphoELM; SysPTM
T464ISLYYtGEKGQPhosphoSitePlus
Y433SKGIAyIEFKTRRM_1PhosphoSitePlus
T213EEAMEtTPAKGPhosphoSitePlus; HPRD; phosphoELM
S42EEDDSsGEEVVPhosphoSitePlus; HPRD; phosphoELM
T301QKVEGtEPTTAPhosphoSitePlus; HPRD
T76KVAVAtPAKKAPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T106AKAVTtPGKKGPhosphoSitePlus; HPRD

Dephosphorylation site
NUCL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318195D36NCOSMICSkin Cancer21984974
ENSP00000318195N541HCOSMICPancreatic Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000318195Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000318195Breast CancerNormal vs. CancertissueUp20560667
ENSP00000318195breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000318195acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000318195MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.4518630942

Hyperphosphorylation site
NUCL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCI_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANNUCL_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NUCL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIEAcellular_component
GO:0005654nucleoplasmIEAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005938cell cortexIDAcellular_component
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001525angiogenesisIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003723RNA bindingIDAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0042162telomeric DNA bindingIDAmolecular_function
GO:0005634nucleusIDAcellular_component


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