| UniProt/SwissProt ID: | NUCL_HUMAN |
| Description: | nucleolin [Source:HGNC Symbol;Acc:7667] |
| Location: | chr2 q37.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T405 | LPYKVtQDELK | RRM_1 | PhosphoSitePlus |
| S609 | RETGSsKGFGF | RRM_1 | PhosphoSitePlus |
| T304 | EGTEPtTAFNL | PhosphoSitePlus; HPRD | |
| T92 | KKAAAtPAKKT | PhosphoSitePlus; HPRD | |
| S184 | AAAPAsEDEDD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S580 | FVKGLsEDTTE | RRM_1 | PhosphoSitePlus |
| T606 | VTDREtGSSKG | RRM_1 | PhosphoSitePlus |
| S145 | AKKEDsDEEED | PhosphoSitePlus; HPRD; phosphoELM | |
| S608 | DRETGsSKGFG | RRM_1 | PhosphoSitePlus |
| T121 | KALVAtPGKKG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T214 | EAMETtPAKGK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y473 | GQNQDyRGGKN | PhosphoSitePlus | |
| S619 | FVDFNsEEDAK | RRM_1 | PhosphoSitePlus; SysPTM |
| S67 | KKVVVsPTKKV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S580 | FVKGLsEDTTE | HPRD; phosphoELM | |
| T641 | DGNKVtLDWAK | RRM_1 | PhosphoSitePlus |
| S28 | EVEEDsEDEEM | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T367 | KALELtGLKVF | RRM_1 | PhosphoSitePlus |
| S595 | ESFDGsVRARI | HPRD | |
| T113 | GKKGAtPGKAL | PhosphoSitePlus; HPRD | |
| T707 | PQGKKtKFE__ | PhosphoSitePlus | |
| S153 | EEDDDsEEDEE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y525 | GKSKGyAFIEF | RRM_1 | PhosphoSitePlus |
| T405 | LPYKVtQDELK | HPRD | |
| S542 | KEALNsCNKRE | RRM_1 | PhosphoSitePlus |
| Y463 | SISLYyTGEKG | PhosphoSitePlus | |
| S496 | SNLSYsATEET | HPRD | |
| S460 | DGRSIsLYYTG | RRM_1 | PhosphoSitePlus |
| Y402 | AKNLPyKVTQD | RRM_1 | PhosphoSitePlus |
| S206 | DEEDDsEEEAM | PhosphoSitePlus; HPRD; phosphoELM | |
| T480 | GGKNStWSGES | PhosphoSitePlus | |
| T498 | LSYSAtEETLQ | RRM_1 | PhosphoSitePlus |
| T367 | KALELtGLKVF | HPRD; phosphoELM | |
| S458 | EIDGRsISLYY | HPRD | |
| T97 | TPAKKtVTPAK | PhosphoSitePlus; HPRD | |
| T602 | RARIVtDRETG | RRM_1 | PhosphoSitePlus |
| T498 | LSYSAtEETLQ | HPRD | |
| S458 | EIDGRsISLYY | RRM_1 | PhosphoSitePlus |
| Y351 | TRKFGyVDFES | RRM_1 | PhosphoSitePlus |
| S423 | EIRLVsKDGKS | RRM_1 | PhosphoSitePlus |
| T487 | SGESKtLVLSN | PhosphoSitePlus | |
| T84 | KKAAVtPGKKA | PhosphoSitePlus; HPRD | |
| T99 | AKKTVtPAKAV | PhosphoSitePlus; HPRD; phosphoELM | |
| S356 | YVDFEsAEDLE | RRM_1 | PhosphoSitePlus |
| S34 | EDEEMsEDEED | PhosphoSitePlus; HPRD; phosphoELM | |
| S428 | SKDGKsKGIAY | RRM_1 | PhosphoSitePlus |
| S532 | FIEFAsFEDAK | RRM_1 | PhosphoSitePlus |
| T69 | VVVSPtKKVAV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S563 | QGPRGsPNARS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T305 | GTEPTtAFNLF | PhosphoSitePlus; HPRD | |
| Y462 | RSISLyYTGEK | PhosphoSitePlus | |
| T105 | PAKAVtTPGKK | PhosphoSitePlus; HPRD; phosphoELM | |
| S41 | DEEDDsSGEEV | PhosphoSitePlus; HPRD; phosphoELM | |
| S619 | FVDFNsEEDAK | HPRD; phosphoELM; SysPTM | |
| T464 | ISLYYtGEKGQ | PhosphoSitePlus | |
| Y433 | SKGIAyIEFKT | RRM_1 | PhosphoSitePlus |
| T213 | EEAMEtTPAKG | PhosphoSitePlus; HPRD; phosphoELM | |
| S42 | EEDDSsGEEVV | PhosphoSitePlus; HPRD; phosphoELM | |
| T301 | QKVEGtEPTTA | PhosphoSitePlus; HPRD | |
| T76 | KVAVAtPAKKA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T106 | AKAVTtPGKKG | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NUCL_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318195 | D36N | COSMIC | Skin Cancer | 21984974 | ENSP00000318195 | N541H | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000318195 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000318195 | Breast Cancer | Normal vs. Cancer | tissue | Up | 20560667 | ENSP00000318195 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | ENSP00000318195 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 17655343 | ENSP00000318195 | Melanoma | Treatment (none vs. kojic acid treatment) | cell line | Down | 0.45 | 18630942 |
| Hyperphosphorylation site |
| NUCL_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCI_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NUCL_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NUCL_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0005654 | nucleoplasm | IEA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005938 | cell cortex | IDA | cellular_component |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0030529 | ribonucleoprotein complex | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001525 | angiogenesis | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0042162 | telomeric DNA binding | IDA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |