Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NTRK1_HUMAN
Description:neurotrophic tyrosine kinase, receptor, type 1 [Source:HGNC Symbol;Acc:8031]
Location:chr1 q23.1
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y755QAPPVyLDVNTRK1HPRD
Y721CPPEVyAIMRGHPRD
Y490IENPQyFSDACNTRK1HPRD
Y640AAGMVyLAGLHRegPhos
Y785QAPPVyLDVNTRK1HPRD
Y676MSRDIySTDYYautocatalysisRegPhos
Y757CPPEVyAIMRGPkinase_TyrPhosphoSitePlus
Y680IYSTDyYRVGGautocatalysisRegPhos
Y681YSTDYyRVGGRRegPhos
Y670MSRDIySTDYYHPRD
Y676MSRDIySTDYYTRKAphosphoELM; RegPhos
Y674IYSTDyYRVGGHPRD
Y791QAPPVyLDVLGTRKARegPhos
Y675YSTDYyRVGGRHPRD
Y701PESILyRKFTTPkinase_TyrPhosphoSitePlus
Y645YSTDYyRVGGRHPRD
Y751CPPEVyAIMRGHPRD
Y460IENPQyFSDACNTRK1HPRD
Y680IYSTDyYRVGGPkinase_TyrPhosphoSitePlus
Y680IYSTDyYRVGGTRKAphosphoELM; RegPhos
Y676MSRDIySTDYYPkinase_TyrPhosphoSitePlus
Y496IENPQyFSDACTRKAphosphoELM; RegPhos
Y791QAPPVyLDVTRKAphosphoELM
Y496IENPQyFSDACPhosphoSitePlus
Y681YSTDYyRVGGRTRKAphosphoELM; RegPhos
Y676MSRDIySTDYYRegPhos
Y644IYSTDyYRVGGHPRD
Y681YSTDYyRVGGRautocatalysisRegPhos
Y680IYSTDyYRVGGRegPhos
S123SRLNLsFNALELRR_8PhosphoSitePlus
Y681YSTDYyRVGGRPkinase_TyrPhosphoSitePlus
Y640MSRDIySTDYYHPRD
Y496IENPQyFSDACautocatalysisRegPhos
Y791QAPPVyLDVLGPhosphoSitePlus
S672GDFGMsRDIYSPkinase_TyrPhosphoSitePlus
Y791QAPPVyLDVLGautocatalysisRegPhos
Y757CPPEVyAIMRGphosphoELM; RegPhos

Dephosphorylation site
NTRK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376120R613WTCGAOvarian Cancer21720365, 18772890
ENSP00000431418L641MBIOMARTBreast Cancer21930507, 21930502
ENSP00000357179L635MBIOMARTBreast Cancer21930507, 21930502
ENSP00000376120R547GCOSMICMelanoma19718025
ENSP00000376120R744GTCGAOvarian Cancer21720365, 18772890
ENSP00000376120L605MBIOMARTBreast Cancer21930507, 21930502
ENSP00000376120A5TCOSMICGastric Cancer21097718
ENSP00000376120R557WCOSMICHead and Neck Cancer21798893
ENSP00000376120D501ECOSMICOvarian Cancer21720365
ENSP00000376120M349ICOSMICMelanoma19718025
ENSP00000376120H453YCOSMICSkin Cancer21984974
ENSP00000376120V384MTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000376120T234MCOSMICOvarian Cancer21720365

Differential expressed protein
NTRK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NTRK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NGF_HUMANNTRK1_HUMANligand -> receptorHPMR
NTF4_HUMANNTRK1_HUMANligand -> receptorHPMR
ZAGL2_HUMANNTRK1_HUMANkinase -> substrateRegPhos
NTRK1_HUMANNTRK1_HUMANkinase -> substrateRegPhos
NGF_HUMANNTRK1_HUMANotherKEGG
BDNF_HUMANNTRK1_HUMANotherKEGG
NTF3_HUMANNTRK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05216Thyroid cancer
hsa05200Pathways in cancer
hsa04144Endocytosis
hsa04722Neurotrophin signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa04210Apoptosis
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0060385axonogenesis involved in innervationIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0014823response to activityIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0010976positive regulation of neuron projection developmeIDAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0031667response to nutrient levelsIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0050965detection of temperature stimulus involved in sensIEAbiological_process
GO:0042490mechanoreceptor differentiationIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0043068positive regulation of programmed cell deathIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0030424axonIEAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009314response to radiationIEAbiological_process
GO:0035094response to nicotineIEAbiological_process
GO:0007611learning or memoryIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayIDAbiological_process
GO:0043068positive regulation of programmed cell deathISSbiological_process
GO:0005166neurotrophin p75 receptor bindingIEAmolecular_function
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0007568agingIEAbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0010623developmental programmed cell deathISSbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0071316cellular response to nicotineIEAbiological_process
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0021553olfactory nerve developmentIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0032320positive regulation of Ras GTPase activityIDAbiological_process
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0048678response to axon injuryIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0051599response to hydrostatic pressureIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0043121neurotrophin bindingTASmolecular_function
GO:0048485sympathetic nervous system developmentISSbiological_process
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0046579positive regulation of Ras protein signal transducIDAbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0030183B cell differentiationIEAbiological_process
GO:0010623developmental programmed cell deathIEAbiological_process
GO:0005768endosomeTAScellular_component
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:1901215negative regulation of neuron deathIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0060385axonogenesis involved in innervationISSbiological_process
GO:0048406nerve growth factor bindingIDAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0050966detection of mechanical stimulus involved in sensoIEAbiological_process
GO:0010465nerve growth factor receptor activityIDAmolecular_function
GO:0007264small GTPase mediated signal transductionTASbiological_process