Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NGF_HUMAN
Description:nerve growth factor (beta polypeptide) [Source:HGNC Symbol;Acc:7808]
Location:chr1 p13.2
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S84KRRLRsPRVLFPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
NGF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358525*242SCOSMICBreast Cancer16959974
ENSP00000358525R95CCOSMICSkin Cancer21984974
ENSP00000358525R49CCOSMICHead and Neck Cancer

Differential expressed protein
NGF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NGF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NGF_HUMANTNR16_HUMANligand -> receptorHPMR
NGF_HUMANNTRK1_HUMANligand -> receptorHPMR
NGF_HUMANSORT_HUMANligand -> receptorHPMR
NGF_HUMANNTRK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04210Apoptosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0009314response to radiationIEAbiological_process
GO:0000186activation of MAPKK activityTASbiological_process
GO:0019233sensory perception of painIEAbiological_process
GO:0045664regulation of neuron differentiationIEAbiological_process
GO:0050772positive regulation of axonogenesisTASbiological_process
GO:0010193response to ozoneIEAbiological_process
GO:0005163nerve growth factor receptor bindingIPImolecular_function
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0005102receptor bindingIEAmolecular_function
GO:0032455nerve growth factor processingTASbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0031954positive regulation of protein autophosphorylationIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0051388positive regulation of nerve growth factor receptoIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0045773positive regulation of axon extensionIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0005768endosomeTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0050770regulation of axonogenesisTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0045786negative regulation of cell cycleTASbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:2000648positive regulation of stem cell proliferationIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0035094response to nicotineIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0042493response to drugIEAbiological_process