Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NTF3_HUMAN
Description:neurotrophin 3 [Source:HGNC Symbol;Acc:8023]
Location:chr12 p13.31
Node attribute:ligand; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y99RQQRRyNSPRVPhosphoSitePlus
Y123YLMEDyVGSPVPhosphoSitePlus
Y139SRRKRyAEHKSPhosphoSitePlus

Dephosphorylation site
NTF3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000328738R138WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000328738R241WCOSMICPancreatic Cancer
ENSP00000328738V128MCOSMICHead and Neck Cancer21798893
ENSP00000397297R151WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000397297R251WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000328738G125RCOSMICOvarian Cancer21720365
ENSP00000328738R238WBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
NTF3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NTF3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NTF3_HUMANNTRK3_HUMANligand -> receptorHPMR
NTF3_HUMANNTRK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005576extracellular regionIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0045687positive regulation of glial cell differentiationIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0048406nerve growth factor bindingIEAmolecular_function
GO:0050918positive chemotaxisIDAbiological_process
GO:0050732negative regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0007411axon guidanceIEAbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0042552myelinationIEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0005165neurotrophin receptor bindingIEAmolecular_function
GO:0007274neuromuscular synaptic transmissionIEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0000187activation of MAPK activityIDAbiological_process
GO:0048484enteric nervous system developmentIEAbiological_process
GO:0008083growth factor activityIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0050930induction of positive chemotaxisIDAbiological_process
GO:2000251positive regulation of actin cytoskeleton reorganiIDAbiological_process
GO:0032856activation of Ras GTPase activityIDAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0042490mechanoreceptor differentiationIEAbiological_process
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0048699generation of neuronsIEAbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0021675nerve developmentIEAbiological_process
GO:0007403glial cell fate determinationIEAbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0043523regulation of neuron apoptotic processIEAbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIDAbiological_process
GO:0002092positive regulation of receptor internalizationIDAbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process