| UniProt/SwissProt ID: | NPY2R_HUMAN |
| Description: | neuropeptide Y receptor Y2 [Source:HGNC Symbol;Acc:7957] |
| Location: | chr4 q32.1 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T217 | KSIYGtVYSLS | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| NPY2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000426366 | S165I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000332591 | S165I | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| NPY2R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NPY2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NPY_HUMAN | NPY2R_HUMAN | ligand -> receptor | HPMR |
| NPY2R_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| NPY2R_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| NPY2R_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| NPY2R_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007626 | locomotory behavior | TAS | biological_process |
| GO:0004983 | neuropeptide Y receptor activity | TAS | molecular_function |
| GO:0004983 | neuropeptide Y receptor activity | IEA | molecular_function |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0003214 | cardiac left ventricle morphogenesis | IMP | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005246 | calcium channel regulator activity | TAS | molecular_function |
| GO:0001601 | peptide YY receptor activity | IEA | molecular_function |
| GO:0003151 | outflow tract morphogenesis | IMP | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |