Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NP1L1_HUMAN
Description:nucleosome assembly protein 1-like 1 [Source:HGNC Symbol;Acc:7637]
Location:chr12 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y110KYAVLyQPLFDNAPPhosphoSitePlus
S242SEPDDsDPFSFNAPPhosphoSitePlus
Y125IINAIyEPTEENAPPhosphoSitePlus
T64LVETPtGYIESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S143EEDEIsEELKENAPPhosphoSitePlus; SysPTM
Y377ENDPDyDPKKDPhosphoSitePlus
S237TYRMRsEPDDSNAPPhosphoSitePlus
T62DGLVEtPTGYIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y66ETPTGyIESLPPhosphoSitePlus; HPRD; phosphoELM
Y96IEAKFyEEVHDNAPPhosphoSitePlus
T269KGKNVtLKTIKNAPPhosphoSitePlus
Y106DLERKyAVLYQNAPPhosphoSitePlus
S143EEDEIsEELKEHPRD; phosphoELM; SysPTM
S10DNKEQsELDQDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S69TGYIEsLPRVVPhosphoSitePlus; HPRD; phosphoELM
T39KARQLtVQMMQPhosphoSitePlus
T31ETGEEtKLKARPhosphoSitePlus
Y223FEPNEyFTNEVNAPPhosphoSitePlus

Dephosphorylation site
NP1L1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376947K276QCOSMICOvarian Cancer21720365
ENSP00000376947T31KCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376947Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.5419329653
ENSP00000376947Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp3.216807943

Hyperphosphorylation site
NP1L1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K7_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NP1L1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0042470melanosomeIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006334nucleosome assemblyIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0005678chromatin assembly complexTAScellular_component
GO:0006260DNA replicationTASbiological_process


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