| UniProt/SwissProt ID: | NOC2L_HUMAN |
| Description: | nucleolar complex associated 2 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:24517] |
| Location: | chr1 p36.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T616 | EGTPLtLYYSH | Noc2 | PhosphoSitePlus |
| S58 | PGGSPsASRRK | PhosphoSitePlus; HPRD | |
| S710 | EGEEDsSNSED | PhosphoSitePlus; HPRD | |
| S682 | DTEGFsERGIL | HPRD | |
| S691 | ILRPLsTRHGV | HPRD | |
| T15 | RLAELtVDEFL | PhosphoSitePlus | |
| S67 | RKGRAsEHKDQ | HPRD | |
| S56 | DKPGGsPSASR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S620 | LTLYYsHWRKL | Noc2 | PhosphoSitePlus |
| S746 | EDLQLsE | HPRD; phosphoELM | |
| S60 | GSPSAsRRKGR | PhosphoSitePlus; HPRD | |
| S28 | GFDSEsESESE | PhosphoSitePlus; HPRD; phosphoELM | |
| S112 | EGPFHsLPDVL | HPRD | |
| S30 | DSESEsESENS | HPRD; phosphoELM | |
| S35 | SESENsPQAET | PhosphoSitePlus; HPRD; phosphoELM | |
| S32 | ESESEsENSPQ | HPRD; phosphoELM | |
| T678 | SEEDDtEGFSE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y618 | TPLTLyYSHWR | Noc2 | PhosphoSitePlus |
| S102 | FSDSDsSEEEE | HPRD; phosphoELM | |
| S103 | SDSDSsEEEEG | HPRD; phosphoELM | |
| S22 | DEFLAsGFDSE | HPRD | |
| S49 | REAARsPDKPG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S238 | RMLQPsSSPLW | PhosphoSitePlus | |
| T40 | SPQAEtREARE | PhosphoSitePlus | |
| S711 | GEEDSsNSEDG | PhosphoSitePlus; HPRD | |
| S240 | LQPSSsPLWGK | HPRD | |
| S673 | FDLNSsEEDDT | PhosphoSitePlus; HPRD; phosphoELM | |
| Y533 | DLTLEyLHSQA | Noc2 | PhosphoSitePlus |
| S93 | QENDQsLLNFS | HPRD; phosphoELM | |
| S713 | EDSSNsEDGDP | PhosphoSitePlus; HPRD | |
| S672 | LFDLNsSEEDD | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S100 | LNFSDsDSSEE | HPRD; phosphoELM | |
| S26 | ASGFDsESESE | PhosphoSitePlus; HPRD; phosphoELM | |
| S746 | EDLQLsEDD__ | PhosphoSitePlus | |
| S98 | SLLNFsDSDSS | HPRD; phosphoELM | |
| S121 | VLEEAsEEEDG | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NOC2L_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000317992 | G108R | COSMIC | Skin Cancer | 21984974 | ENSP00000317992 | N565H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000317992 | S67P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| NOC2L_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NOC2L_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK7_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ILK_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK3_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | NOC2L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NOC2L_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070491 | repressing transcription factor binding | IDA | molecular_function |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0003682 | chromatin binding | IDA | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IMP | biological_process |
| GO:0005678 | chromatin assembly complex | IDA | cellular_component |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0032066 | nucleolus to nucleoplasm transport | IDA | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0042393 | histone binding | IDA | molecular_function |
| GO:0035067 | negative regulation of histone acetylation | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0031491 | nucleosome binding | IDA | molecular_function |
| GO:0002903 | negative regulation of B cell apoptotic process | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0034644 | cellular response to UV | IDA | biological_process |