Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP2BB_HUMAN
Description:protein phosphatase 3, catalytic subunit, beta isozyme [Source:HGNC Symbol;Acc:9315]
Location:chr10 q22.2
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S471AIRGFsPPHRIPhosphoSitePlus
S478PHRICsFEEAKPhosphoSitePlus
S420MARVFsVLREEPhosphoSitePlus

Dephosphorylation site
PP2BB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378305R288SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353881R288SBIOMARTBreast Cancer21930507, 21930502
ENSP00000353881P50LCOSMICMelanoma
ENSP00000378299R306SBIOMARTBreast Cancer21930507, 21930502
ENSP00000378306R288SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PP2BB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PP2BB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PP2BB_HUMANNFAC2_HUMANphosphatase -> substrateHPRD; NetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04728Dopaminergic synapse
hsa04360Axon guidance
hsa05031Amphetamine addiction
hsa04650Natural killer cell mediated cytotoxicity
hsa05166HTLV-I infection
hsa04310Wnt signaling pathway
hsa04114Oocyte meiosis
hsa04662B cell receptor signaling pathway
hsa04010MAPK signaling pathway
hsa05152Tuberculosis
hsa04660T cell receptor signaling pathway
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04380Osteoclast differentiation
hsa05010Alzheimer's disease
hsa04724Glutamatergic synapse
hsa04720Long-term potentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006470protein dephosphorylationIEAbiological_process
GO:0048675axon extensionTASbiological_process
GO:0005509calcium ion bindingIDAmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0006470protein dephosphorylationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0033192calmodulin-dependent protein phosphatase activityIEAmolecular_function
GO:0005886plasma membraneISScellular_component
GO:0035774positive regulation of insulin secretion involved IEAbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0001915negative regulation of T cell mediated cytotoxicitIEAbiological_process
GO:0007612learningTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0046983protein dimerization activityIPImolecular_function
GO:0005955calcineurin complexIDAcellular_component
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0042098T cell proliferationNASbiological_process
GO:0035774positive regulation of insulin secretion involved ISSbiological_process
GO:0035176social behaviorIEPbiological_process
GO:0016311dephosphorylationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0033192calmodulin-dependent protein phosphatase activityISSmolecular_function
GO:0017156calcium ion-dependent exocytosisIEAbiological_process
GO:0035690cellular response to drugIDAbiological_process
GO:0030346protein phosphatase 2B bindingIDAmolecular_function
GO:0007613memoryTASbiological_process
GO:0019899enzyme bindingIDAmolecular_function
GO:0007165signal transductionNASbiological_process
GO:0048167regulation of synaptic plasticityTASbiological_process
GO:0004722protein serine/threonine phosphatase activityNASmolecular_function
GO:0042110T cell activationTASbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0005516calmodulin bindingIDAmolecular_function
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0017156calcium ion-dependent exocytosisISSbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0050796regulation of insulin secretionISSbiological_process