| UniProt/SwissProt ID: | NELFB_HUMAN |
| Description: | negative elongation factor complex member B [Source:HGNC Symbol;Acc:24324] |
| Location: | chr9 q34.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T564 | AQAAEtPALEL | COBRA1 | PhosphoSitePlus |
| S557 | DHRKPsPAQAA | HPRD; phosphoELM; SysPTM | |
| S557 | DHRKPsPAQAA | COBRA1 | PhosphoSitePlus; SysPTM |
| T330 | LVGQEtLPRDS | COBRA1 | PhosphoSitePlus |
| T564 | AQAAEtPALEL | HPRD | |
| T406 | VSYPNtLPESF | HPRD | |
| S573 | ELPLPsVPAPA | HPRD; SysPTM | |
| Dephosphorylation site |
| NELFB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339495 | P394L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000339495 | K364T | COSMIC | Skin Cancer | 21984974 | ENSP00000339495 | G198S | COSMIC | Skin Cancer | 21984974 | ENSP00000339495 | A268V | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000339495 | Ovarian Cancer | Treatment (cisplatin-sensitive vs. cisplatin-resistant) | cell line | Down | 0.21 | 16319398 |
| Hyperphosphorylation site |
| NELFB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DDR1_HUMAN | NELFB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | NELFB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| HIPK1_HUMAN | NELFB_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NELFB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0050434 | positive regulation of viral transcription | TAS | biological_process |
| GO:0032021 | NELF complex | IDA | cellular_component |
| GO:0006368 | transcription elongation from RNA polymerase II pr | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |