| UniProt/SwissProt ID: | ROCK2_HUMAN |
| Description: | Rho-associated, coiled-coil containing protein kinase 2 [Source:HGNC Symbol;Acc:10252] |
| Location: | chr2 p25.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T567 | RQLDEtNALLR | Myosin_tail_1 | PhosphoSitePlus |
| S298 | PFYADsLVGTY | Pkinase | PhosphoSitePlus |
| S1366 | SSPRTsMKIQQ | PhosphoSitePlus | |
| Y1232 | IFQILyANEGE | PH | PhosphoSitePlus |
| S1379 | SIRRPsRQLAP | PhosphoSitePlus | |
| S1133 | IGLDSsSIGSG | PhosphoSitePlus; HPRD; phosphoELM | |
| Y722 | DKNKIyESIEE | PhosphoSitePlus; HPRD; SysPTM | |
| Y936 | IAEEQySDLEK | PhosphoSitePlus | |
| T577 | RTESDtAARLR | Myosin_tail_1 | PhosphoSitePlus |
| S1374 | IQQNQsIRRPS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S724 | NKIYEsIEEAK | PhosphoSitePlus | |
| S575 | LLRTEsDTAAR | Myosin_tail_1 | PhosphoSitePlus |
| S1132 | HIGLDsSSIGS | PhosphoSitePlus; HPRD; phosphoELM | |
| T567 | RQLDEtNALLR | HPRD | |
| S425 | LLLSDsPSCRE | PhosphoSitePlus; HPRD; SysPTM | |
| S1238 | ANEGEsKKEQE | PH | PhosphoSitePlus |
| T1078 | EREKLtQQMIK | PhosphoSitePlus; HPRD; phosphoELM | |
| S1361 | DPFARsSPRTS | HPRD; SysPTM | |
| S1362 | PFARSsPRTSM | HPRD; SysPTM | |
| S1134 | GLDSSsIGSGP | PhosphoSitePlus; HPRD; phosphoELM | |
| T1165 | PVRNNtKKFGW | PH | PhosphoSitePlus |
| S1137 | SSSIGsGPGDA | PhosphoSitePlus; HPRD; phosphoELM | |
| Y1319 | PCKVYyDISTA | PH | PhosphoSitePlus |
| S1121 | IEQLRsQLQAL | HPRD | |
| T573 | NALLRtESDTA | Myosin_tail_1 | PhosphoSitePlus |
| Dephosphorylation site |
| ROCK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000317985 | N657T | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000317985 | Breast Cancer | Normal vs. Cancer | cell line | Up | 5.2 | 20052998 | ENSP00000317985 | Breast Cancer | Normal vs. Cancer | cell line | Up | 8 | 20052998 | ENSP00000317985 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.39 | 20052998 | ENSP00000317985 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.64 | 20052998 | ENSP00000317985 | Breast Cancer | Metastasis | cell line | Down | 0.049 | 20052998 | ENSP00000317985 | Breast Cancer | Metastasis | cell line | Down | 0.12 | 20052998 |
| Hyperphosphorylation site |
| ROCK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ROCK2_HUMAN | DPYL2_HUMAN | kinase -> substrate | RegPhos |
| ROCK2_HUMAN | MYPT1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa04510 | Focal adhesion |
| hsa04062 | Chemokine signaling pathway |
| hsa04310 | Wnt signaling pathway |
| hsa05131 | Shigellosis |
| hsa04670 | Leukocyte transendothelial migration |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05132 | Salmonella infection |
| hsa04350 | TGF-beta signaling pathway |
| hsa04270 | Vascular smooth muscle contraction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001843 | neural tube closure | IEA | biological_process |
| GO:2000114 | regulation of establishment of cell polarity | TAS | biological_process |
| GO:0051492 | regulation of stress fiber assembly | TAS | biological_process |
| GO:0045616 | regulation of keratinocyte differentiation | IMP | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0031616 | spindle pole centrosome | IEA | cellular_component |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0032956 | regulation of actin cytoskeleton organization | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005813 | centrosome | IEA | cellular_component |
| GO:2000145 | regulation of cell motility | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0051893 | regulation of focal adhesion assembly | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0030155 | regulation of cell adhesion | TAS | biological_process |
| GO:0010825 | positive regulation of centrosome duplication | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005198 | structural molecule activity | NAS | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006939 | smooth muscle contraction | TAS | biological_process |
| GO:0016525 | negative regulation of angiogenesis | IMP | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0000910 | cytokinesis | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0051298 | centrosome duplication | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |