| UniProt/SwissProt ID: | SQSTM_HUMAN |
| Description: | sequestosome 1 [Source:HGNC Symbol;Acc:11280] |
| Location: | chr5 q35.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S277 | SPESSsTEEKS | PhosphoSitePlus; HPRD; phosphoELM | |
| Y433 | LDTIQySKHPP | PhosphoSitePlus | |
| S349 | KEVDPsTGELQ | PhosphoSitePlus | |
| S275 | PVSPEsSSTEE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y148 | SVCPDyDLCSV | phosphoELM | |
| Y89 | TMAMSyVKDDI | HPRD | |
| S24 | EIRRFsFCCSP | HPRD | |
| S170 | KLAFPsPFGHL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S24 | EIRRFsFCCSP | PB1 | PhosphoSitePlus |
| Y383 | KEAALyPHLPP | PhosphoSitePlus | |
| T375 | SQEGPtGLKEA | PhosphoSitePlus; HPRD | |
| S276 | VSPESsSTEEK | PhosphoSitePlus; HPRD; phosphoELM | |
| S282 | STEEKsSSQPS | PhosphoSitePlus; HPRD; phosphoELM | |
| S266 | HGGKRsRLTPV | PhosphoSitePlus; HPRD; phosphoELM | |
| Y9 | LTVKAyLLGKE | PhosphoSitePlus | |
| S287 | SSSQPsSCCSD | HPRD; phosphoELM | |
| T339 | GDDDWtHLSSK | PhosphoSitePlus; HPRD | |
| S434 | DTIQYsKHPPP | PhosphoSitePlus | |
| S180 | LSEGFsHSRWL | HPRD; SysPTM | |
| S332 | ESDNCsGGDDD | PhosphoSitePlus; HPRD; phosphoELM | |
| S226 | TAESAsGPSED | PhosphoSitePlus; HPRD | |
| S318 | KIALEsEGRPE | HPRD | |
| S291 | PSSCCsDPSKP | PhosphoSitePlus; HPRD; phosphoELM | |
| S288 | SSQPSsCCSDP | PhosphoSitePlus; HPRD; phosphoELM | |
| S403 | LSQMLsMGFSD | PhosphoSitePlus | |
| S328 | EEQMEsDNCSG | PhosphoSitePlus; HPRD; phosphoELM | |
| S176 | PFGHLsEGFSH | HPRD | |
| S343 | WTHLSsKEVDP | PhosphoSitePlus; HPRD; phosphoELM | |
| S342 | DWTHLsSKEVD | PhosphoSitePlus; HPRD | |
| S249 | VAAALsPLGIE | PhosphoSitePlus; HPRD | |
| S284 | EEKSSsQPSSC | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T278 | PESSStEEKSS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T430 | GAALDtIQYSK | PhosphoSitePlus | |
| S49 | CERLLsRVAAL | PB1 | PhosphoSitePlus |
| S366 | SEGPSsLDPSQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T269 | KRSRLtPVSPE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S272 | RLTPVsPESSS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S361 | LQMPEsEGPSS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S355 | TGELQsLQMPE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y67 | GFQAHyRDEDG | PB1 | PhosphoSitePlus |
| S28 | FSFCCsPEPEA | PB1 | PhosphoSitePlus; SysPTM |
| S207 | PPGNWsPRPPR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y148 | SVCPDyDLCSV | ZZ | PhosphoSitePlus |
| S283 | TEEKSsSQPSS | HPRD | |
| S370 | SSLDPsQEGPT | PhosphoSitePlus; HPRD | |
| S28 | FSFCCsPEPEA | HPRD; phosphoELM; SysPTM | |
| S182 | EGFSHsRWLRK | HPRD; phosphoELM; SysPTM | |
| S365 | ESEGPsSLDPS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| SQSTM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353944 | D9Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000374455 | D93Y | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000374455 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 0.32 | 19016532 |
| Hyperphosphorylation site |
| SQSTM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MYO3A_HUMAN | SQSTM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| SQSTM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031410 | cytoplasmic vesicle | IEA | cellular_component |
| GO:0006511 | ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0042169 | SH2 domain binding | IDA | molecular_function |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0019901 | protein kinase binding | IDA | molecular_function |
| GO:0043130 | ubiquitin binding | IDA | molecular_function |
| GO:0000932 | cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
| GO:0046578 | regulation of Ras protein signal transduction | NAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005080 | protein kinase C binding | IPI | molecular_function |
| GO:0000407 | pre-autophagosomal structure | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0005764 | lysosome | IEA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0016236 | macroautophagy | ISS | biological_process |
| GO:0005770 | late endosome | IEA | cellular_component |
| GO:0030971 | receptor tyrosine kinase binding | TAS | molecular_function |
| GO:0006914 | autophagy | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016197 | endosomal transport | TAS | biological_process |
| GO:0008104 | protein localization | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | NAS | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0001934 | positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB cascade | IMP | biological_process |
| GO:0070530 | K63-linked polyubiquitin binding | IEA | molecular_function |
| GO:0051291 | protein heterooligomerization | IEA | biological_process |
| GO:0005776 | autophagic vacuole | IDA | cellular_component |
| GO:0045944 | positive regulation of transcription from RNA poly | TAS | biological_process |