Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SQSTM_HUMAN
Description:sequestosome 1 [Source:HGNC Symbol;Acc:11280]
Location:chr5 q35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S277SPESSsTEEKSPhosphoSitePlus; HPRD; phosphoELM
Y433LDTIQySKHPPPhosphoSitePlus
S349KEVDPsTGELQPhosphoSitePlus
S275PVSPEsSSTEEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y148SVCPDyDLCSVphosphoELM
Y89TMAMSyVKDDIHPRD
S24EIRRFsFCCSPHPRD
S170KLAFPsPFGHLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S24EIRRFsFCCSPPB1PhosphoSitePlus
Y383KEAALyPHLPPPhosphoSitePlus
T375SQEGPtGLKEAPhosphoSitePlus; HPRD
S276VSPESsSTEEKPhosphoSitePlus; HPRD; phosphoELM
S282STEEKsSSQPSPhosphoSitePlus; HPRD; phosphoELM
S266HGGKRsRLTPVPhosphoSitePlus; HPRD; phosphoELM
Y9LTVKAyLLGKEPhosphoSitePlus
S287SSSQPsSCCSDHPRD; phosphoELM
T339GDDDWtHLSSKPhosphoSitePlus; HPRD
S434DTIQYsKHPPPPhosphoSitePlus
S180LSEGFsHSRWLHPRD; SysPTM
S332ESDNCsGGDDDPhosphoSitePlus; HPRD; phosphoELM
S226TAESAsGPSEDPhosphoSitePlus; HPRD
S318KIALEsEGRPEHPRD
S291PSSCCsDPSKPPhosphoSitePlus; HPRD; phosphoELM
S288SSQPSsCCSDPPhosphoSitePlus; HPRD; phosphoELM
S403LSQMLsMGFSDPhosphoSitePlus
S328EEQMEsDNCSGPhosphoSitePlus; HPRD; phosphoELM
S176PFGHLsEGFSHHPRD
S343WTHLSsKEVDPPhosphoSitePlus; HPRD; phosphoELM
S342DWTHLsSKEVDPhosphoSitePlus; HPRD
S249VAAALsPLGIEPhosphoSitePlus; HPRD
S284EEKSSsQPSSCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T278PESSStEEKSSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T430GAALDtIQYSKPhosphoSitePlus
S49CERLLsRVAALPB1PhosphoSitePlus
S366SEGPSsLDPSQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T269KRSRLtPVSPEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S272RLTPVsPESSSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S361LQMPEsEGPSSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S355TGELQsLQMPEPhosphoSitePlus; HPRD; phosphoELM
Y67GFQAHyRDEDGPB1PhosphoSitePlus
S28FSFCCsPEPEAPB1PhosphoSitePlus; SysPTM
S207PPGNWsPRPPRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y148SVCPDyDLCSVZZPhosphoSitePlus
S283TEEKSsSQPSSHPRD
S370SSLDPsQEGPTPhosphoSitePlus; HPRD
S28FSFCCsPEPEAHPRD; phosphoELM; SysPTM
S182EGFSHsRWLRKHPRD; phosphoELM; SysPTM
S365ESEGPsSLDPSPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
SQSTM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353944D9YBIOMARTBreast Cancer21930507, 21930502
ENSP00000374455D93YBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000374455Hepatocellular CarcinomaMetastasiscell lineDown0.3219016532

Hyperphosphorylation site
SQSTM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MYO3A_HUMANSQSTM_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SQSTM_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0006511ubiquitin-dependent protein catabolic processTASbiological_process
GO:0006950response to stressTASbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0019901protein kinase bindingIDAmolecular_function
GO:0043130ubiquitin bindingIDAmolecular_function
GO:0000932cytoplasmic mRNA processing bodyIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0046578regulation of Ras protein signal transductionNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005080protein kinase C bindingIPImolecular_function
GO:0000407pre-autophagosomal structureIEAcellular_component
GO:0035556intracellular signal transductionTASbiological_process
GO:0005764lysosomeIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0016236macroautophagyISSbiological_process
GO:0005770late endosomeIEAcellular_component
GO:0030971receptor tyrosine kinase bindingTASmolecular_function
GO:0006914autophagyIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042802identical protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0016197endosomal transportTASbiological_process
GO:0008104protein localizationTASbiological_process
GO:0004674protein serine/threonine kinase activityNASmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043122regulation of I-kappaB kinase/NF-kappaB cascadeIMPbiological_process
GO:0070530K63-linked polyubiquitin bindingIEAmolecular_function
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0005776autophagic vacuoleIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyTASbiological_process


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