| UniProt/SwissProt ID: | MLRV_HUMAN |
| Description: | myosin, light chain 2, regulatory, cardiac, slow [Source:HGNC Symbol;Acc:7583] |
| Location: | chr12 q24.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y152 | TGNLDyKNLVH | efhand | PhosphoSitePlus |
| Y118 | VLKADyVREML | efhand | PhosphoSitePlus |
| S15 | AGGANsNVFSM | PhosphoSitePlus | |
| T124 | VREMLtTQAER | efhand | PhosphoSitePlus |
| S19 | NSNVFsMFEQT | PhosphoSitePlus | |
| S19 | NSNVFsMFEQT | CDC42BPA | HPRD |
| Dephosphorylation site |
| MLRV_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000228841 | D48Y | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| MLRV_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MLRV_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MRCKA_HUMAN | MLRV_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05410 | Hypertrophic cardiomyopathy (HCM) |
| hsa04260 | Cardiac muscle contraction |
| hsa04510 | Focal adhesion |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04530 | Tight junction |
| hsa05414 | Dilated cardiomyopathy |
| hsa04670 | Leukocyte transendothelial migration |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0055010 | ventricular cardiac muscle tissue morphogenesis | IMP | biological_process |
| GO:0060048 | cardiac muscle contraction | IEA | biological_process |
| GO:0032036 | myosin heavy chain binding | NAS | molecular_function |
| GO:0030017 | sarcomere | TAS | cellular_component |
| GO:0060047 | heart contraction | IEA | biological_process |
| GO:0008307 | structural constituent of muscle | NAS | molecular_function |
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0060047 | heart contraction | ISS | biological_process |
| GO:0030049 | muscle filament sliding | TAS | biological_process |
| GO:0016459 | myosin complex | TAS | cellular_component |
| GO:0009791 | post-embryonic development | IEA | biological_process |
| GO:0030016 | myofibril | IEA | cellular_component |
| GO:0003007 | heart morphogenesis | IEA | biological_process |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0030308 | negative regulation of cell growth | IMP | biological_process |
| GO:0055003 | cardiac myofibril assembly | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006942 | regulation of striated muscle contraction | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0042694 | muscle cell fate specification | IEA | biological_process |
| GO:0048747 | muscle fiber development | IEA | biological_process |
| GO:0005856 | cytoskeleton | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003785 | actin monomer binding | IDA | molecular_function |