Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MRCKA_HUMAN
Description:CDC42 binding protein kinase alpha (DMPK-like) [Source:HGNC Symbol;Acc:1737]
Location:chr1 q42.13
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1532NKRRYsFRVPEHPRD
S1173SQLSAsNNKCSPhosphoSitePlus
Y1416TIRLIyFKNKMHPRD
S1706PRKTKsLSLESHPRD
T846LASKMtEELEAPhosphoSitePlus; HPRD
S1611TVFSGsVSIPSPhosphoSitePlus
S725KELHDsEGQQLMyosin_tail_1PhosphoSitePlus
S1639LSARSsAQNGSPhosphoSitePlus
T1725LSLEStDRGSWPhosphoSitePlus
S1703TASNSsNLSSPPhosphoSitePlus
Y1544NNKRRySFRVPPhosphoSitePlus
S1629PGRSMsASSGLPhosphoSitePlus
S1724SLSLEsTDRGSPhosphoSitePlus
S1641EFSGGsYSAKRHPRD
Y474VQALQySTVDGMyosin_tail_1PhosphoSitePlus
S1616SVSIPsITKSRPhosphoSitePlus
S843LQALAsKMTEEPhosphoSitePlus
S2EVRLHPRD
T862LGTRAtDMPWKPhosphoSitePlus
T1492LLGLEtIRLIYHPRD
S1378CVGFQsGFLRYCNHPhosphoSitePlus
S1654EFSGGsYSAKRPhosphoSitePlus
S1545NKRRYsFRVPEPhosphoSitePlus; phosphoELM
T1411LLGLEtIRLIYHPRD
S1557LKREFsGGSYSHPRD
S1719PRKTKsLSLESPhosphoSitePlus; phosphoELM
S475QALQYsTVDGPMyosin_tail_1PhosphoSitePlus
S1710LSSPPsPASPRPhosphoSitePlus
S856ALRNSsLGTRAPhosphoSitePlus
S1721KTKSLsLESTDPhosphoSitePlus; phosphoELM
T240SVAVGtPDYISPkinasePhosphoSitePlus
Y1497TIRLIyFKNKMHPRD
S1700RHSTAsNSSNLPhosphoSitePlus
S1625PRKTKsLSLESHPRD
S1613FSGSVsIPSITPhosphoSitePlus
Y1510TIRLIyFKNKMPhosphoSitePlus
T403PFVGFtYTSSCPkinase_CPhosphoSitePlus
S1656SGGSYsAKRQPPhosphoSitePlus
S222LADFGsCLKLMPkinasePhosphoSitePlus
S1638LKREFsGGSYSHPRD
T765LASKMtEELEAHPRD
T1185LMLADtENEKNPhosphoSitePlus
Y444LATEAyERRIKMyosin_tail_1PhosphoSitePlus
S1451NKRRYsFRVPEHPRD
S1651LKREFsGGSYSPhosphoSitePlus
S1708KTKSLsLESTDHPRD
T1505LLGLEtIRLIYPhosphoSitePlus
S234DGTVQsSVAVGPkinasePhosphoSitePlus
S1171TASQLsASNNKPhosphoSitePlus
S2____MsGEVRLPhosphoSitePlus
S1632SMSASsGLSARPhosphoSitePlus
S1627KTKSLsLESTDHPRD
S1560EFSGGsYSAKRHPRD

Dephosphorylation site
MRCKA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355731R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355729S344CDing2008, COSMICLung Cancer18948947
ENSP00000355729E175VDing2008, COSMICLung Cancer18948947
ENSP00000355731I530MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000355729R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000335341R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355727R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355726R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355729I744LCOSMICGastric Cancer21097718
ENSP00000355729R460KDing2008, COSMICLung Cancer18948947
ENSP00000355727E50KGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000355729I530MCOSMICLung Cancer18948947
ENSP00000355729E50KGreenman2007, COSMICLung Cancer16140923, 17344846, 18428421
ENSP00000355729L1576FCOSMICOvarian Cancer21720365
ENSP00000355728R328*BIOMARTBreast Cancer21930507, 21930502
ENSP00000355729E299QDing2008, COSMICLung Cancer18948947

Differential expressed protein
MRCKA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MRCKA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MRCKA_HUMANLIMK1_HUMANkinase -> substrateHPRD
MRCKA_HUMANMLRV_HUMANkinase -> substrateHPRD
MRCKA_HUMANLIMK2_HUMANkinase -> substrateHPRD
MRCKA_HUMANPP12C_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
MRCKA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0031252cell leading edgeISScellular_component
GO:0042641actomyosinIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0031032actomyosin structure organizationIMPbiological_process
GO:0031532actin cytoskeleton reorganizationIDAbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0016477cell migrationIMPbiological_process
GO:0007097nuclear migrationIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005911cell-cell junctionISScellular_component


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