| UniProt/SwissProt ID: | MOS_HUMAN |
| Description: | v-mos Moloney murine sarcoma viral oncogene homolog [Source:HGNC Symbol;Acc:7199] |
| Location: | chr8 q12.1 |
| Node attribute: | kinase; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T339 | LLVDLtSLKAE | PhosphoSitePlus | |
| S340 | LVDLTsLKAEL | PhosphoSitePlus | |
| Y79 | VYKATyRGVPV | Pkinase | PhosphoSitePlus |
| S16 | LRSEFsPSVDA | HPRD; phosphoELM | |
| Y263 | PKADIySFAIT | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| MOS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000310722 | *347C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000310722 | *347S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000310722 | A123T | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000310722 | S99Y | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| MOS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MOS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MOS_HUMAN | MP2K1_HUMAN | kinase -> substrate | KEGG |
| MOS_HUMAN | TIF1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MOS_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MOS_HUMAN | MBNL3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MOS_HUMAN | MP2K2_HUMAN | kinase -> substrate | KEGG |
| RRAS2_HUMAN | MOS_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04114 | Oocyte meiosis |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04010 | MAPK signaling pathway |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0040020 | regulation of meiosis | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |