| UniProt/SwissProt ID: | MMP1_HUMAN |
| Description: | matrix metallopeptidase 1 (interstitial collagenase) [Source:HGNC Symbol;Acc:7155] |
| Location: | chr11 q22.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S280 | PKACDsKLTFD | HPRD | |
| Y360 | NVLHGyPKDIY | Hemopexin | PhosphoSitePlus |
| S153 | TFTKVsEGQAD | Peptidase_M10 | PhosphoSitePlus |
| Y360 | NVLHGyPKDIY | HPRD | |
| T289 | FDAITtIRGEV | HPRD | |
| T288 | TFDAItTIRGE | HPRD | |
| Dephosphorylation site |
| MMP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000322788 | L181I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000322788 | E313Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000322788 | V312I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000322788 | E39K | COSMIC | Skin Cancer | 21984974 | ENSP00000322788 | A330S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000322788 | T274I | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000322788 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.054 | 19053080 |
| Hyperphosphorylation site |
| MMP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ETV5_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| SMAD4_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| JUN_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| FOS_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| SMAD3_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| ETS1_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| ETV4_HUMAN | MMP1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MMP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0022617 | extracellular matrix disassembly | TAS | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0004222 | metalloendopeptidase activity | IDA | molecular_function |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0030574 | collagen catabolic process | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0008237 | metallopeptidase activity | IEA | molecular_function |