Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK06_HUMAN
Description:mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:6879]
Location:chr15 q21.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S688HSPVGsPLKSIPhosphoSitePlus
S189HKGHLsEGLVTErk3(MAPK6RegPhos; SysPTM
S189HKGHLsEGLVTMAPK_groupphosphoELM; RegPhos; SysPTM
S363HDCQFsEHDWPPhosphoSitePlus
S483NWKEQsKEKSDPhosphoSitePlus
T54KKIVLtDPQSVPkinasePhosphoSitePlus
Y209LSPNNyTKAIDPkinasePhosphoSitePlus
Y628NTYTSyLDKFFRegPhos
S684IPQFHsPVGSPPhosphoSitePlus
S665GFLNNsGEFLFPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S189HKGHLsEGLVTPkinasePhosphoSitePlus; SysPTM
S189HKGHLsEGLVTphosphoELM; SysPTM
T626KENTYtSYLDKRegPhos
S386DPRALsDVTDEPhosphoSitePlus; HPRD; phosphoELM
S189HKGHLsEGLVTErk3RegPhos; SysPTM
T389ALSDVtDEEEVPhosphoSitePlus; HPRD; phosphoELM
S705SAMKSsPQIPHPhosphoSitePlus
S189HKGHLsEGLVTMAPK6HPRD; phosphoELM; SysPTM
S452KTRSSsYLDNLPhosphoSitePlus
Y467SEVNHyYEPKLPhosphoSitePlus
T698IQATLtPSAMKPhosphoSitePlus
Y182IMDPHySHKGHPkinasePhosphoSitePlus
Y453TRSSSyLDNLVPhosphoSitePlus
T644TEMLEtEPVEDPhosphoSitePlus

Dephosphorylation site
MK06_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261845R64CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261845T534ABIOMARTBreast Cancer21930507, 21930502
ENSP00000261845K489TTCGAOvarian Cancer21720365, 18772890
ENSP00000261845L290VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000261845G234CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MK06_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK06_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMK06_HUMANkinase -> substrateRegPhos
MK06_HUMANPDLI5_HUMANkinase -> substrateRobert H Newman (2013)
MK06_HUMANORC1_HUMANkinase -> substrateRobert H Newman (2013)
MK06_HUMANDAZP1_HUMANkinase -> substrateRobert H Newman (2013)
MK06_HUMANRCC1_HUMANkinase -> substrateRobert H Newman (2013)
MK06_HUMANMK06_HUMANkinase -> substrateHPRD
MK06_HUMANIEX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MK06_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004707MAP kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusISScellular_component
GO:0005634nucleusIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0004707MAP kinase activityISSmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0000165MAPK cascadeIEAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmISScellular_component


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