Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IEX1_HUMAN
Description:immediate early response 3 [Source:HGNC Symbol;Acc:5392]
Location:chrHSCHR6_MHC_COX p2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S31GPRRGsGPEIFPhosphoSitePlus; HPRD; phosphoELM
T18ILQAPtPAPSTErk3(MAPK6RegPhos
T18ILQAPtPAPSTMAPK1HPRD
T18ILQAPtPAPSTMAPK6phosphoELM
S55GRPSAsRGHRKHPRD; phosphoELM
T18ILQAPtPAPSTErk2RegPhos
T18ILQAPtPAPSTPhosphoSitePlus
S53PAGRPsASRGHHPRD; phosphoELM

Dephosphorylation site
IEX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000259874A107GBIOMARTBreast Cancer21930507, 21930502
ENSP00000259874*157SCOSMICMelanoma9354451

Differential expressed protein
IEX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IEX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANIEX1_HUMANkinase -> substrateHPRD
MK06_HUMANIEX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
IEX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0006915apoptotic processTASbiological_process
GO:2001020regulation of response to DNA damage stimulusIMPbiological_process
GO:0001562response to protozoanIEAbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0045820negative regulation of glycolysisIEAbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:2000377regulation of reactive oxygen species metabolic prIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045732positive regulation of protein catabolic processIEAbiological_process
GO:0003085negative regulation of systemic arterial blood preIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process


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