Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCM7_HUMAN
Description:minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:6950]
Location:chr7 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T406LADYItAAYVEHPRD
Y6MALKDyALEKEPhosphoSitePlus
S324YNPRRsLEQNIHPRD
S309VKMNKsEDDESPhosphoSitePlus; HPRD
Y600SKDATyTSARTMCMPhosphoSitePlus
S500YNPRRsLEQNIMCMPhosphoSitePlus; SysPTM
S113MMEQRsRDPGMPhosphoSitePlus; HPRD
S549SRQPPsQFEPLMCMPhosphoSitePlus
Y6LEKEHPRD
Y492AANPAyGRYNPMCMPhosphoSitePlus
T144GAGELtREELRHPRD
S121PGMVRsPQNQYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S133VKMNKsEDDESHPRD
T320GAGELtREELRMCMPhosphoSitePlus
Y580ESLADyITAAYMCMPhosphoSitePlus
S678RSVRFsEAEQRPhosphoSitePlus
S500YNPRRsLEQNIHPRD; phosphoELM; SysPTM
S549SRQPPsQFEPLHPRD; phosphoELM
S189GGVDQsPRGMKHPRD
T320GAGELtREELRHPRD
S314SEDDEsGAGELPhosphoSitePlus
S392KSQLLsYIDRLMCMPhosphoSitePlus
T582LADYItAAYVEHPRD
S373SRQPPsQFEPLHPRD
S365GGVDQsPRGMKHPRD
S365GGVDQsPRGMKMCMPhosphoSitePlus

Dephosphorylation site
MCM7_HUMAN do not have dephosphorylation site.

Mutation site
MCM7_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000307288Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4118646787

Hyperphosphorylation site
MCM7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK2_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
CDC7_HUMANMCM7_HUMANkinase -> substrateRegPhos
KS6A5_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
ATR_HUMANMCM7_HUMANkinase -> substrateRegPhos
ARAF_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMCM7_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMCM7_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa03030DNA replication

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0071364cellular response to epidermal growth factor stimuIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIDAmolecular_function
GO:0003697single-stranded DNA bindingIEAmolecular_function
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0015979photosynthesisIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0000785chromatinTAScellular_component
GO:0016851magnesium chelatase activityIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0006270DNA replication initiationIEAbiological_process
GO:0006268DNA unwinding involved in replicationIEAbiological_process
GO:0003678DNA helicase activityIEAmolecular_function
GO:0015995chlorophyll biosynthetic processIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0042555MCM complexIMPcellular_component
GO:0005634nucleusIEAcellular_component
GO:0016887ATPase activityIEAmolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0005829cytosolIEAcellular_component
GO:0042325regulation of phosphorylationIMPbiological_process


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