Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MATK_HUMAN
Description:megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:6906]
Location:chr19 p13.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S502ADGSTsPRSQHPRD
S463STSPRsQHPRD
S504STSPRsQEP__PhosphoSitePlus
S460ADGSTsPRSQHPRD
S505STSPRsQHPRD
S85ACENKsWYRVKSH3_1PhosphoSitePlus
T501DADGStSPRSQHPRD
T500DADGStSPRSQPhosphoSitePlus; HPRD; phosphoELM
S504STSPRsQHPRD; phosphoELM
T459DADGStSPRSQHPRD
T76KGDVVtILEACSH3_1PhosphoSitePlus
S501ADGSTsPRSQEPhosphoSitePlus; SysPTM
S501ADGSTsPRSQHPRD; phosphoELM; SysPTM
Y87ENKSWyRVKHHSH3_1PhosphoSitePlus

Dephosphorylation site
MATK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308734R503QHPIColorectal Cancer17344846
ENSP00000308734R503QGreenman2007Intestines Cancer17344846, 18428421
ENSP00000308734A354TGreenman2007, HPIOvarian Cancer17344846, 18428421
ENSP00000378485E417ADing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MATK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MATK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MATK_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MATK_HUMANLYN_HUMANkinase -> substrateHPRD; RegPhos
MATK_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
MATK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0008283cell proliferationTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0007498mesoderm developmentTASbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0004672protein kinase activityIEAmolecular_function


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