Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LAT_HUMAN
Description:linker for activation of T cells [Source:HGNC Symbol;Acc:18874]
Location:chr16 p11.2
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y131YHNPGyLVVLPZAP70HPRD
S241PAALSsQEAEEPhosphoSitePlus
Y226EGAPDyENLQEZAP70HPRD
T39GSYDStSSDSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y255EGAPDyENLQEZAP70HPRD; RegPhos
S195EYVNVsQELHPHPRD
S206VNVPEsGESAEPhosphoSitePlus
S217ASLDGsREYVNPhosphoSitePlus
Y171ESIDDyVNVPEHPRD
Y127EDEDDyHNPGYZAP70HPRD
S40SYDSTsSDSLYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y255EGAPDyENLQEPhosphoSitePlus; RegPhos
S101SSRRDsDGANSPhosphoSitePlus; HPRD; phosphoELM
S84LPIPRsPQPLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y171ESIDDyVNVPEZAP70HPRD
S96SHRTPsSRRDSPhosphoSitePlus
T94GGSHRtPSSRRPhosphoSitePlus
T184APALStPGIRDPhosphoSitePlus
Y191DGSREyVNVSQHPRD
Y156EDEDDyHNPGYPhosphoSitePlus; RegPhos
Y200ESIDDyVNVPEPhosphoSitePlus; RegPhos
S35HRLPGsYDSTSPhosphoSitePlus
S38PGSYDsTSSDSPhosphoSitePlus; phosphoELM; RegPhos
Y170ESIDDyVNVPEZAP70HPRD
Y36RLPGSyDSTSSPhosphoSitePlus
Y161YHNPGyLVVLPPhosphoSitePlus; RegPhos
S224EYVNVsQELHPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y156EDEDDyHNPGYZAP70HPRD; RegPhos
Y161YHNPGyLVVLPZAP70HPRD; RegPhos
Y70PPVTSyPPLSQPhosphoSitePlus
S109ANSVAsYENEGPhosphoSitePlus; HPRD; phosphoELM
S183SAPALsTPGIRPhosphoSitePlus
S213ESAEAsLDGSRPhosphoSitePlus
S41YDSTSsDSLYPPhosphoSitePlus
S106SDGANsVASYEPhosphoSitePlus
Y191DGSREyVNVSQZAP70HPRD
Y220DGSREyVNVSQZAP70HPRD; RegPhos
S43STSSDsLYPRGPhosphoSitePlus
Y132YHNPGyLVVLPZAP70HPRD
S83LLPIPsPQPLGHPRD
S91QPLGGsHRTPSPhosphoSitePlus
Y126EDEDDyHNPGYZAP70HPRD
S74SYPPLsQPDLLPhosphoSitePlus
S240EPAALsSQEAEPhosphoSitePlus
Y220DGSREyVNVSQPhosphoSitePlus; phosphoELM; RegPhos
Y45SSDSLyPRGIQPhosphoSitePlus
T68AYPPVtSYPPLPhosphoSitePlus
Y225EGAPDyENLQEZAP70HPRD
Y200ESIDDyVNVPEZAP70HPRD; RegPhos
S97HRTPSsRRDSDPhosphoSitePlus
Y110NSVASyENEGAPhosphoSitePlus; RegPhos
S194EYVNVsQELHPHPRD
Y190DGSREyVNVSQZAP70HPRD

Dephosphorylation site
LAT_HUMAN do not have dephosphorylation site.

Mutation site
LAT_HUMAN do not have mutation site.

Differential expressed protein
LAT_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LAT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAP70_HUMANLAT_HUMANkinase -> substrateRegPhos; NetPath
KSYK_HUMANLAT_HUMANkinase -> substrateKEGG
ITK_HUMANLAT_HUMANkinase -> substrateNetPath
ZAGL2_HUMANLAT_HUMANkinase -> substrateRegPhos
PTPRJ_HUMANLAT_HUMANphosphatase -> substrateNetPath
LAT_HUMANGRB2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04660T cell receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007265Ras protein signal transductionIMPbiological_process
GO:0006955immune responseIDAbiological_process
GO:0016021integral to membraneIDAcellular_component
GO:0042110T cell activationTASbiological_process
GO:0045121membrane raftTAScellular_component
GO:0008180signalosomeISScellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0043303mast cell degranulationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0001772immunological synapseIDAcellular_component
GO:0007229integrin-mediated signaling pathwayIDAbiological_process
GO:0019722calcium-mediated signalingIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0035556intracellular signal transductionIDAbiological_process
GO:0005070SH3/SH2 adaptor activityIDAmolecular_function
GO:0050863regulation of T cell activationIMPbiological_process


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