Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LASP1_HUMAN
Description:LIM and SH3 protein 1 [Source:HGNC Symbol;Acc:6513]
Location:chr17 q12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S151SQDGSsYRRPLPhosphoSitePlus; HPRD; RegPhos
T63PKQSFtMVADTHPRD
S146PERRDsQDGSSPKG1/cGK-IphosphoELM; SysPTM
Y171TSAPVyQQPQQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y52YEKKPyCNAHYLIMPhosphoSitePlus
S99KGKGFsVVADTP31323(Protein kinase cA)RegPhos
S146PERRDsQDGSSPKG2/cGK-IIphosphoELM; SysPTM
S167HHIPTsAPVYQPhosphoSitePlus
S146PERRDsQDGSSPKG1RegPhos; SysPTM
S146PERRDsQDGSSPKG2RegPhos; SysPTM
S118TQDQIsNIKYHHPRD
S118TQDQIsNIKYHNebulinPhosphoSitePlus
T38ETCKMtLNMKNHPRD
S146PERRDsQDGSSPRKG2HPRD; SysPTM
S146PERRDsQDGSSPRKAR2BHPRD; SysPTM
Y241DDGWMyGTVERSH3_1PhosphoSitePlus
S82QSELQsQVRYKNebulinPhosphoSitePlus
T68TMVADtPENLRNebulinPhosphoSitePlus; SysPTM
T113QRIKKtQDQISNebulinPhosphoSitePlus
Y183PVAQSyGGYKEPhosphoSitePlus
Y257MLPANyVEAI_PhosphoSitePlus
Y122ISNIKyHEEFEHPRD
S146PERRDsQDGSSPKA_groupphosphoELM; RegPhos; SysPTM
S99KGKGFsVVADTPRKAR2BHPRD
T104SVVADtPELQRHPRD; phosphoELM; RegPhos; SysPTM
S134SRMGPsGGEGMHPRD
S61HYPKQsFTMVALIMPhosphoSitePlus
T104SVVADtPELQRNebulinPhosphoSitePlus; SysPTM
Y86QSQVRyKEEFENebulinPhosphoSitePlus
S146PERRDsQDGSSPhosphoSitePlus; phosphoELM; SysPTM
Y152QDGSSyRRPLEPhosphoSitePlus; HPRD; phosphoELM
T68TMVADtPENLRHPRD; phosphoELM; RegPhos; SysPTM
S182QPVAQsYGGYKPhosphoSitePlus
Y57YCNAHyPKQSFLIMPhosphoSitePlus
S194PAAPVsIQRSAPhosphoSitePlus
T38ETCKMtLNMKNzf-C2HC5; LIMPhosphoSitePlus
T166PHHIPtSAPVYPhosphoSitePlus
S61HYPKQsFTMVAPRKG2HPRD
Y13CGKIVyPTEKVzf-C2HC5; LIMPhosphoSitePlus
Y122ISNIKyHEEFENebulinPhosphoSitePlus
S146PERRDsQDGSSP31323(Protein kinase cA)RegPhos; SysPTM
S150DSQDGsSYRRPPhosphoSitePlus; HPRD
S146PERRDsQDGSSCDK7HPRD; phosphoELM; RegPhos; SysPTM
S61HYPKQsFTMVAPKG2RegPhos
Y186QSYGGyKEPAAPhosphoSitePlus
Y47KNYKGyEKKPYLIMPhosphoSitePlus

Dephosphorylation site
LASP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000325240V12MCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000325240Non-small cell lung carcinomaMetastasiscell lineDown17537172
ENSP00000325240Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.218646787
ENSP00000325240Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.719120023
ENSP00000325240Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.3320804217
ENSP00000325240chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000325240acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1717655343
ENSP00000325240Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.716807943
ENSP00000325240Biliary Tract CancerMetastasiscell lineDown0.1819299076

Hyperphosphorylation site
LASP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK7_HUMANLASP1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KGP2_HUMANLASP1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANLASP1_HUMANkinase -> substrateRegPhos
KAP3_HUMANLASP1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
LASP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0051015actin filament bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0030864cortical actin cytoskeletonIEAcellular_component
GO:0034220ion transmembrane transportIEAbiological_process
GO:0006811ion transportISSbiological_process
GO:0005925focal adhesionIEAcellular_component
GO:0006811ion transportIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0015075ion transmembrane transporter activityIEAmolecular_function


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