Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KAP3_HUMAN
Description:protein kinase, cAMP-dependent, regulatory, type II, beta [Source:HGNC Symbol;Acc:9392]
Location:chr7 q22.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S114FTRRAsVCAEAPRKAR2BHPRD; SysPTM
S85PMQSDsEDGEEPhosphoSitePlus; HPRD
T69AAGGGtPSKGVPhosphoSitePlus; HPRD
T357ELALVtNKPRAcNMP_bindingPhosphoSitePlus
S114FTRRAsVCAEAPKB_groupphosphoELM; SysPTM
T417DIVEPtA____PhosphoSitePlus
S83EEPMQsDSEDGPhosphoSitePlus; HPRD
Y120VCAEAyNPDEEPhosphoSitePlus
S114FTRRAsVCAEAPKA_groupphosphoELM; SysPTM
S114FTRRAsVCAEAPhosphoSitePlus; phosphoELM; SysPTM

Dephosphorylation site
KAP3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265717E223KTCGAOvarian Cancer21720365, 18772890
ENSP00000440531E223KCOSMICOvarian Cancer21720365
ENSP00000440531E223KTCGAOvarian Cancer21720365, 18772890
ENSP00000265717E223KCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265717Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueUp4.816807943

Hyperphosphorylation site
KAP3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KAP3_HUMANLASP1_HUMANkinase -> substrateHPRD
KAP3_HUMANKAP3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04210Apoptosis
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0050796regulation of insulin secretionTASbiological_process
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0045121membrane raftIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0097338response to clozapineIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0055085transmembrane transportTASbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0001932regulation of protein phosphorylationIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0006833water transportTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0008603cAMP-dependent protein kinase regulator activityIEAmolecular_function
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0007612learningIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0097332response to antipsychotic drugIEAbiological_process
GO:0005952cAMP-dependent protein kinase complexIEAcellular_component
GO:0030552cAMP bindingIEAmolecular_function


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