| UniProt/SwissProt ID: | KHDR2_HUMAN |
| Description: | KH domain containing, RNA binding, signal transduction associated 2 [Source:HGNC Symbol;Acc:18114] |
| Location: | chr6 q11.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y163 | FLVPDyNDEIR | PhosphoSitePlus | |
| S106 | ILGKGsMRDKA | KH_1 | PhosphoSitePlus |
| Y6 | MEEEKyLPELM | PhosphoSitePlus | |
| T95 | RLQEEtGAKMS | HPRD | |
| S106 | ILGKGsMRDKA | HPRD | |
| S25 | SFVHAsRLLAE | PhosphoSitePlus | |
| Dephosphorylation site |
| KHDR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000281156 | L28M | COSMIC | Melanoma | 21499247 | ENSP00000281156 | L60F | COSMIC | Melanoma | 21499247 | ENSP00000281156 | R348I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000281156 | P245S | COSMIC | Melanoma | 21499247 | ENSP00000281156 | A24V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000281156 | H150Y | COSMIC | Melanoma | ENSP00000281156 | D15A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000281156 | R186C | COSMIC | Melanoma | 21499247 | ENSP00000281156 | P19L | COSMIC | Skin Cancer | 21984974 | ENSP00000281156 | D315H | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000281156 | R206L | COSMIC | Hepatocellular Carcinoma | ENSP00000281156 | R224W | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| KHDR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KHDR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FAK2_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | KHDR2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KHDR2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042169 | SH2 domain binding | IEA | molecular_function |
| GO:0008266 | poly(U) RNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0008143 | poly(A) RNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |