| UniProt/SwissProt ID: | PTPS_HUMAN |
| Description: | 6-pyruvoyltetrahydropterin synthase [Source:HGNC Symbol;Acc:9689] |
| Location: | chr11 q23.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S23 | ISFSAsHRLYS | HPRD | |
| S19 | VSRRIsFSASH | PKG2 | RegPhos; SysPTM |
| S19 | VSRRIsFSASH | HPRD; phosphoELM; SysPTM | |
| S19 | VSRRIsFSASH | PRKG2 | HPRD; SysPTM |
| S19 | VSRRIsFSASH | PKG_group | RegPhos; SysPTM |
| S21 | RRISFsASHRL | HPRD | |
| Y128 | PVGVLyKVKVY | PTPS | PhosphoSitePlus |
| S19 | VSRRIsFSASH | PTPS | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| PTPS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PTPS_HUMAN do not have mutation site. |
| Differential expressed protein |
| PTPS_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTPS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KGP2_HUMAN | PTPS_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00790 | Folate biosynthesis |
| hsa01100 | Metabolic pathways |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |
| GO:0046209 | nitric oxide metabolic process | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0050999 | regulation of nitric-oxide synthase activity | TAS | biological_process |
| GO:0003874 | 6-pyruvoyltetrahydropterin synthase activity | IEA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0006729 | tetrahydrobiopterin biosynthetic process | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042802 | identical protein binding | IEA | molecular_function |
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0006520 | cellular amino acid metabolic process | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |