Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAG1_HUMAN
Description:jagged 1 [Source:HGNC Symbol;Acc:6188]
Location:chr20 p12.2
Node attribute:PPI(source); glycosylation(target); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1139VPIKDyENKNSPhosphoSitePlus
T219QNGNKtCMEGWDSLPhosphoSitePlus
Y1176AKQPAyTLVDRPhosphoSitePlus
T1177KQPAYtLVDREPhosphoSitePlus

Dephosphorylation site
JAG1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000254958E1019KCOSMICBreast Cancer20668451
ENSP00000254958D684YCOSMICLung Cancer
ENSP00000254958R235*COSMICCentral Nervous System Neoplasms21163964
ENSP00000254958P279LCOSMICCentral Nervous System Neoplasms18772890
ENSP00000254958R1213QCOSMICLung Cancer20668451
ENSP00000254958N966KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000254958P848LCOSMICOvarian Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000254958Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
JAG1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAG1_HUMANNOTC2_HUMANligand -> receptorHPMR
JAG1_HUMANNOTC1_HUMANligand -> receptorHPMR
JAG1_HUMANNOTC3_HUMANligand -> receptorHPMR
OFUT1_HUMANJAG1_HUMANglycosylationNetPath
MFNG_HUMANJAG1_HUMANglycosylationNetPath
JAG1_HUMANNOTC1_HUMANotherKEGG
P63_HUMANJAG1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005112Notch bindingIEAmolecular_function
GO:0003215cardiac right ventricle morphogenesisIEAbiological_process
GO:0045446endothelial cell differentiationNASbiological_process
GO:0061156pulmonary artery morphogenesisIMPbiological_process
GO:0072017distal tubule developmentIEAbiological_process
GO:0032495response to muramyl dipeptideIEAbiological_process
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:0061444endocardial cushion cell developmentIEAbiological_process
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0061309cardiac neural crest cell development involved in IEAbiological_process
GO:0007399nervous system developmentNASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0005576extracellular regionNAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0030334regulation of cell migrationNASbiological_process
GO:0003184pulmonary valve morphogenesisIMPbiological_process
GO:0060411cardiac septum morphogenesisIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0042127regulation of cell proliferationNASbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0007275multicellular organismal developmentNASbiological_process
GO:0005198structural molecule activityNASmolecular_function
GO:0045177apical part of cellIEAcellular_component
GO:0009887organ morphogenesisIEAbiological_process
GO:0030216keratinocyte differentiationNASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0097150neuronal stem cell maintenanceIEPbiological_process
GO:0030097hemopoiesisNASbiological_process
GO:0061314Notch signaling involved in heart developmentIEAbiological_process
GO:0042491auditory receptor cell differentiationIEAbiological_process
GO:0001525angiogenesisNASbiological_process
GO:0045639positive regulation of myeloid cell differentiatioIEAbiological_process
GO:0016020membraneTAScellular_component
GO:2000737negative regulation of stem cell differentiationIMPbiological_process
GO:0072070loop of Henle developmentIEAbiological_process
GO:0007154cell communicationIEAbiological_process
GO:0001709cell fate determinationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0035909aorta morphogenesisIEAbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0007219Notch signaling pathwayIMPbiological_process
GO:0045747positive regulation of Notch signaling pathwayIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0045445myoblast differentiationNASbiological_process
GO:0008083growth factor activityNASmolecular_function