Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOTC3_HUMAN
Description:notch 3 [Source:HGNC Symbol;Acc:7883]
Location:chr19 p13.12
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S84EDPCHsGPCAGPhosphoSitePlus
Y1849HLAARyARADAPhosphoSitePlus
Y1197TCPPGyTGLRCPhosphoSitePlus
S1672RKREHsTLWFPPhosphoSitePlus
T211CRNGGtCRQSGPhosphoSitePlus
Y529DQPDGyECRCAPhosphoSitePlus
T1908MADGStALILAPhosphoSitePlus

Dephosphorylation site
NOTC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263388V356ACOSMICOvarian Cancer21720365
ENSP00000263388P226SCOSMICSkin Cancer21984974
ENSP00000263388V1155MCOSMICCentral Nervous System Neoplasms18772396
ENSP00000263388P914LDing2008, COSMICLung Cancer18948947
ENSP00000263388Q1699*COSMICMelanoma21499247
ENSP00000263388R1589QCOSMICHead and Neck Cancer21798893
ENSP00000263388L1795MCOSMICOvarian Cancer21720365
ENSP00000263388P2074LCOSMICLung Cancer18948947
ENSP00000263388G1104WCOSMICLung Cancer20668451
ENSP00000263388Q1699ECOSMICBreast Cancer20668451
ENSP00000263388G413DCOSMICLung Cancer20668451
ENSP00000263388D1124GCOSMICLung Cancer20668451
ENSP00000263388E434KCOSMICHead and Neck Cancer21798893
ENSP00000263388Q1830*COSMICProstate Cancer20668451
ENSP00000263388C617SCOSMICHead and Neck Cancer21798893
ENSP00000263388I1760MCOSMICOvarian Cancer21720365
ENSP00000263388H325YCOSMICMelanoma21499247
ENSP00000263388K1473*COSMICHead and Neck Cancer21798893
ENSP00000263388G1612*COSMICLung Cancer20668451
ENSP00000263388M1704RCOSMICOvarian Cancer21720365
ENSP00000263388P2074LDing2008Lung Cancer18948947

Differential expressed protein
NOTC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NOTC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAG1_HUMANNOTC3_HUMANligand -> receptorHPMR
JAG2_HUMANNOTC3_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04330Notch signaling pathway
hsa04320Dorso-ventral axis formation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0048663neuron fate commitmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0072104glomerular capillary formationIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0050793regulation of developmental processIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0019899enzyme bindingIEAmolecular_function
GO:0007220Notch receptor processingTASbiological_process
GO:0000139Golgi membraneTAScellular_component