Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IL2RB_HUMAN
Description:interleukin 2 receptor, beta [Source:HGNC Symbol;Acc:6009]
Location:chr22 q12.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T282VLKCNtPDPSKPhosphoSitePlus
Y387FTYDPySEEDPLckphosphoELM; RegPhos
Y387FTYDPySEEDPPhosphoSitePlus
Y536LNTDAyLSLQELckphosphoELM; RegPhos
Y364FTNQGyFFFHLJAK1HPRD; RegPhos
S293FFSQLsSEHGGPhosphoSitePlus
S458ERMPPsLQERVPhosphoSitePlus
Y364FTNQGyFFFHLPhosphoSitePlus; phosphoELM; RegPhos
Y536LNTDAyLSLQEPhosphoSitePlus
Y418GEDDAyCTFPSPhosphoSitePlus
Y418GEDDAyCTFPSLckphosphoELM; RegPhos
Y418GEDDAyCTFPSLCKHPRD; RegPhos
T105TVDIVtLRVLCIL6Ra-bind; APOBEC_CPhosphoSitePlus
Y381EACQVyFTYDPPhosphoSitePlus
Y387FTYDPySEEDPLCKHPRD; RegPhos
Y536LNTDAyLSLQELCKHPRD; RegPhos
Y381EACQVyFTYDPLckphosphoELM; RegPhos
Y381EACQVyFTYDPLCKHPRD; RegPhos
Y384QVYFTyDPYSEPhosphoSitePlus
Y384QVYFTyDPYSELckphosphoELM; RegPhos
Y384QVYFTyDPYSELCKHPRD; RegPhos

Dephosphorylation site
IL2RB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216223Y262*BIOMARTBreast Cancer21930507, 21930502
ENSP00000216223D426ECOSMICOvarian Cancer21720365
ENSP00000216223W152*COSMICSkin Cancer21984974

Differential expressed protein
IL2RB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IL2RB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANIL2RB_HUMANkinase -> substrateRegPhos
JAK1_HUMANIL2RB_HUMANkinase -> substrateHPRD; RegPhos; NetPath
LCK_HUMANIL2RB_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
PTN6_HUMANIL2RB_HUMANphosphatase -> substrateNetPath
GABPA_HUMANIL2RB_HUMANTF -> target geneTRANSFAC
ETS1_HUMANIL2RB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa05166HTLV-I infection
hsa05202Transcriptional misregulation in cancer
hsa04630Jak-STAT signaling pathway
hsa04144Endocytosis
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneTAScellular_component
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0038110interleukin-2-mediated signaling pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0004911interleukin-2 receptor activityTASmolecular_function
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0019976interleukin-2 bindingIEAmolecular_function


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