Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IF4E_HUMAN
Description:eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:3287]
Location:chr4 q23
Node attribute:PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S209ATKSGsTTKNRPRKCAHPRD
S209ATKSGsTTKNRPRKCBHPRD
S209ATKSGsTTKNRMNK2RegPhos
S209ATKSGsTTKNRMNK1RegPhos
S209ATKSGsTTKNRPRKCGHPRD
T3___MAtVEPETPhosphoSitePlus
S53FKNDKsKTWQAIF4EPhosphoSitePlus
T210TKSGStTKNRFPhosphoSitePlus
T9VEPETtPTPNPPhosphoSitePlus; HPRD
Y183HIGRVyKERLGIF4EPhosphoSitePlus
T22TEEEKtESNQEHPRD
S209ATKSGsTTKNRPKCgRegPhos
S209ATKSGsTTKNRPKCaRegPhos
S209ATKSGsTTKNRPKCbRegPhos
S53FKNDKsKTWQAHPRD; phosphoELM; RegPhos
S209ATKSGsTTKNRMKNK2HPRD
S209ATKSGsTTKNRMKNK1HPRD
T17PNPPTtEEEKTPhosphoSitePlus
S209ATKSGsTTKNRPhosphoSitePlus; phosphoELM
S209ATKSGsTTKNRMnk2phosphoELM; RegPhos
S209ATKSGsTTKNRMnk1phosphoELM; RegPhos
T203QSHADtATKSGPhosphoSitePlus
T16TPNPPtTEEEKPhosphoSitePlus
S209ATKSGsTTKNRPKC_groupRegPhos

Dephosphorylation site
IF4E_HUMAN do not have dephosphorylation site.

Mutation site
IF4E_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000389624LeukemiaNormal vs. Cancercell lineUp6.417022645
ENSP00000389624LeukemiaNormal vs. Cancercell lineUp3.317022645
ENSP00000389624Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineDown0.1614557597

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S209DTATKSGsTTKNRFVpsoriasis19663871PhosphoSitePlus
S209DTATKSGsTTKNRFVprostate cancer20679199PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCG_HUMANIF4E_HUMANkinase -> substrateHPRD
ZAGL2_HUMANIF4E_HUMANkinase -> substrateRegPhos
KPCB_HUMANIF4E_HUMANkinase -> substrateHPRD
MKNK1_HUMANIF4E_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KPCA_HUMANIF4E_HUMANkinase -> substrateHPRD
MKNK2_HUMANIF4E_HUMANkinase -> substrateKEGG; HPRD; RegPhos; Robert H Newman (2013)
4EBP1_HUMANIF4E_HUMANotherKEGG
MYC_HUMANIF4E_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa03013RNA transport
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0005845mRNA cap binding complexIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0000288nuclear-transcribed mRNA catabolic process, deadenTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016281eukaryotic translation initiation factor 4F compleIEAcellular_component
GO:0010494cytoplasmic stress granuleIDAcellular_component
GO:0006406mRNA export from nucleusTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005845mRNA cap binding complexIDAcellular_component
GO:0031370eukaryotic initiation factor 4G bindingIEAmolecular_function
GO:0006417regulation of translationIEAbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0000932cytoplasmic mRNA processing bodyIDAcellular_component
GO:0006412translationTASbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0016442RNA-induced silencing complexIDAcellular_component
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0003743translation initiation factor activityISSmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0006413translational initiationTASbiological_process
GO:0000339RNA cap bindingTASmolecular_function
GO:0016070RNA metabolic processTASbiological_process
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0000289nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process


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