Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HIPK2_HUMAN
Description:homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:14402]
Location:chr7 q34
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S46MTGYGsHSKVYPhosphoSitePlus
Y361AVCSTyLQSRYHPRD; phosphoELM
Y366YLQSRyYRAPEPkinasePhosphoSitePlus
T221CWKRGtNEIVAPkinasePhosphoSitePlus
S827SQAISsPQRSKPhosphoSitePlus
Y360KAVCStYLQSRHPRD
T360KAVCStYLQSRPkinasePhosphoSitePlus
S359SKAVCsTYLQSPkinasePhosphoSitePlus
T796MRQQPtSTTSSPhosphoSitePlus
T838RVKENtPPRCAPhosphoSitePlus
Y361AVCSTyLQSRYPkinasePhosphoSitePlus
S364STYLQsRYYRAPkinasePhosphoSitePlus
Y367LQSRYyRAPEIPkinasePhosphoSitePlus
S826SSQAIsSPQRSPhosphoSitePlus

Dephosphorylation site
HIPK2_HUMAN do not have dephosphorylation site.

Mutation site
HIPK2_HUMAN do not have mutation site.

Differential expressed protein
HIPK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
HIPK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK2_HUMANP53_HUMANkinase -> substrateHPRD; RegPhos
HIPK2_HUMANRUNX1_HUMANkinase -> substrateHPRD
HIPK2_HUMANPAX6_HUMANkinase -> substrateHPRD
HIPK2_HUMANCTBP1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
HIPK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051726regulation of cell cycleTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationISSbiological_process
GO:0042771intrinsic apoptotic signaling pathway in response IEAbiological_process
GO:0030578PML body organizationTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016604nuclear bodyIDAcellular_component
GO:0060235lens induction in camera-type eyeIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiISSbiological_process
GO:0043388positive regulation of DNA bindingIEAbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0019048virus-host interactionNASbiological_process
GO:0032092positive regulation of protein bindingISSbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0030514negative regulation of BMP signaling pathwayIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0018107peptidyl-threonine phosphorylationIEAbiological_process
GO:0001654eye developmentISSbiological_process
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0001105RNA polymerase II transcription coactivator activiISSmolecular_function
GO:0071456cellular response to hypoxiaTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0060059embryonic retina morphogenesis in camera-type eyeIEAbiological_process
GO:0046790virion bindingIPImolecular_function
GO:0061072iris morphogenesisIEAbiological_process
GO:0010842retina layer formationIEAbiological_process
GO:0018105peptidyl-serine phosphorylationISSbiological_process
GO:0030511positive regulation of transforming growth factor IMPbiological_process
GO:0042771intrinsic apoptotic signaling pathway in response TASbiological_process
GO:0001102RNA polymerase II activating transcription factor ISSmolecular_function
GO:0031965nuclear membraneIDAcellular_component
GO:0060395SMAD protein signal transductionIDAbiological_process
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0005737cytoplasmISScellular_component
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0001102RNA polymerase II activating transcription factor IEAmolecular_function
GO:0007628adult walking behaviorIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0004674protein serine/threonine kinase activityISSmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0030218erythrocyte differentiationISSbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0046330positive regulation of JNK cascadeIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016605PML bodyIDAcellular_component
GO:0097193intrinsic apoptotic signaling pathwayNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045766positive regulation of angiogenesisIDAbiological_process
GO:0001105RNA polymerase II transcription coactivator activiIEAmolecular_function
GO:0050882voluntary musculoskeletal movementIEAbiological_process
GO:0003714transcription corepressor activityIEAmolecular_function
GO:0006978DNA damage response, signal transduction by p53 clIDAbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process