Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAX6_HUMAN
Description:paired box 6 [Source:HGNC Symbol;Acc:8620]
Location:chr11 p13
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S216QRNRTsFTQEQHPRD; phosphoELM
T373SYDTYtPPHMQHIPK2HPRD
S216QRNRTsFTQEQHomeoboxPhosphoSitePlus
T295RQASNtPSHIPHIPK2HPRD
T373SYDTYtPPHMQPhosphoSitePlus
T304IPQPTtPVSSFHIPK2HPRD
T387SYDTYtPPHMQHIPK2HPRD
T317PIPQPtTPVSSHIPK2HPRD
T281RQASNtPSHIPHIPK2HPRD
S230QRNRTsFTQEQHPRD

Dephosphorylation site
PAX6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000368401Q149ECOSMICOvarian Cancer21720365
ENSP00000368401G190VCOSMICOvarian Cancer21720365
ENSP00000404100Q149ECOSMICOvarian Cancer21720365
ENSP00000368401E195KCOSMICMelanoma21499247
ENSP00000404100E195KCOSMICMelanoma21499247
ENSP00000368410R139GCOSMICCentral Nervous System Neoplasms21163964
ENSP00000368424N164KCOSMICLung Cancer20668451
ENSP00000368410Q149ECOSMICOvarian Cancer21720365
ENSP00000368424R139GCOSMICCentral Nervous System Neoplasms21163964
ENSP00000368424G190VCOSMICOvarian Cancer21720365
ENSP00000368410E195KCOSMICMelanoma21499247
ENSP00000404100G190VCOSMICOvarian Cancer21720365
ENSP00000368410G190VCOSMICOvarian Cancer21720365
ENSP00000368401N164KCOSMICLung Cancer20668451
ENSP00000368424Q149ECOSMICOvarian Cancer21720365
ENSP00000368424E195KCOSMICMelanoma21499247
ENSP00000368410N164KCOSMICLung Cancer20668451
ENSP00000368401R139GCOSMICCentral Nervous System Neoplasms21163964
ENSP00000404100R139GCOSMICCentral Nervous System Neoplasms21163964
ENSP00000404100N164KCOSMICLung Cancer20668451

Differential expressed protein
PAX6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PAX6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK2_HUMANPAX6_HUMANkinase -> substrateHPRD
TFCP2_HUMANPAX6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04950Maturity onset diabetes of the young

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033365protein localization to organelleIEAbiological_process
GO:0030858positive regulation of epithelial cell differentiaIEAbiological_process
GO:0021796cerebral cortex regionalizationIEAbiological_process
GO:0016567protein ubiquitinationISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007417central nervous system developmentTASbiological_process
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0048663neuron fate commitmentNASbiological_process
GO:0007435salivary gland morphogenesisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0001709cell fate determinationIEAbiological_process
GO:0009950dorsal/ventral axis specificationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0070410co-SMAD bindingIEAmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0021905forebrain-midbrain boundary formationIEAbiological_process
GO:0000790nuclear chromatinIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0045664regulation of neuron differentiationIEAbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0004842ubiquitin-protein ligase activityISSmolecular_function
GO:0021912regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0042462eye photoreceptor cell developmentIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0035035histone acetyltransferase bindingIEAmolecular_function
GO:0050768negative regulation of neurogenesisISSbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIMPbiological_process
GO:0032808lacrimal gland developmentIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0023019signal transduction involved in regulation of geneIEAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0048505regulation of timing of cell differentiationIEAbiological_process
GO:0007224smoothened signaling pathwayIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0050767regulation of neurogenesisIEAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0009953dorsal/ventral pattern formationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0007601visual perceptionTASbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0007417central nervous system developmentIEAbiological_process
GO:0021918regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0021798forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0048708astrocyte differentiationIEAbiological_process
GO:0021543pallium developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0021913regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0042660positive regulation of cell fate specificationIEAbiological_process
GO:0070412R-SMAD bindingIEAmolecular_function
GO:0030334regulation of cell migrationIEAbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0021983pituitary gland developmentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002088lens development in camera-type eyeIEAbiological_process
GO:0043010camera-type eye developmentIEAbiological_process
GO:0021778oligodendrocyte cell fate specificationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0001568blood vessel developmentIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0021902commitment of neuronal cell to specific neuron typIEAbiological_process
GO:0003680AT DNA bindingIEAmolecular_function
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0003322pancreatic A cell developmentIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0010468regulation of gene expressionIEAbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0061303cornea development in camera-type eyeIMPbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0021797forebrain anterior/posterior pattern specificationIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0009611response to woundingIEPbiological_process
GO:0001654eye developmentTASbiological_process
GO:0061072iris morphogenesisIMPbiological_process
GO:0044424intracellular partIEAcellular_component