| UniProt/SwissProt ID: | GRP3_HUMAN |
| Description: | RAS guanyl releasing protein 3 (calcium and DAG-regulated) [Source:HGNC Symbol;Acc:14545] |
| Location: | chr2 p22.3 |
| Node attribute: | PPI(source); substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T133 | WMRRVtQRKKV | PhosphoSitePlus; HPRD; RegPhos | |
| S638 | FPKMKsKFHDK | PhosphoSitePlus | |
| T133 | WMRRVtQRKKV | PKC_theta | phosphoELM |
| T133 | WMRRVtQRKKV | PKCt(PKC theta | RegPhos |
| T610 | LQRATtSQATQ | PhosphoSitePlus | |
| Dephosphorylation site |
| GRP3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000385886 | D175N | COSMIC | Lung Cancer | ENSP00000384192 | D175N | COSMIC | Lung Cancer | ENSP00000384192 | F452L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000384192 | F452L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384192 | T506A | COSMIC | Lung Cancer | 20668451 | ENSP00000384192 | N283S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385886 | N283S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000385886 | T506A | COSMIC | Lung Cancer | 20668451 | ENSP00000385886 | F452L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384192 | I448L | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000385886 | F452L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| GRP3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRP3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCB_HUMAN | GRP3_HUMAN | kinase -> substrate | NetPath |
| ZAGL2_HUMAN | GRP3_HUMAN | kinase -> substrate | RegPhos |
| KPCT_HUMAN | GRP3_HUMAN | kinase -> substrate | NetPath; Robert H Newman (2013) |
| PLCG2_HUMAN | GRP3_HUMAN | other | KEGG |
| GRP3_HUMAN | RASH_HUMAN | other | KEGG |
| SOS1_HUMAN | GRP3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04662 | B cell receptor signaling pathway |
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032045 | guanyl-nucleotide exchange factor complex | IEA | cellular_component |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0032854 | positive regulation of Rap GTPase activity | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0005509 | calcium ion binding | NAS | molecular_function |
| GO:0004871 | signal transducer activity | TAS | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0019900 | kinase binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0043087 | regulation of GTPase activity | IEA | biological_process |
| GO:0019992 | diacylglycerol binding | NAS | molecular_function |
| GO:0046582 | Rap GTPase activator activity | IDA | molecular_function |
| GO:0000165 | MAPK cascade | NAS | biological_process |