| UniProt/SwissProt ID: | GRM8_HUMAN |
| Description: | glutamate receptor, metabotropic 8 [Source:HGNC Symbol;Acc:4600] |
| Location: | chr7 q31.33 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S867 | AATMQsKLIQK | PhosphoSitePlus | |
| T864 | VVTAAtMQSKL | PhosphoSitePlus; HPRD | |
| Y471 | DAPGRyDIFQY | ANF_receptor | PhosphoSitePlus |
| S107 | ILDTCsRDTYA | ANF_receptor | PhosphoSitePlus |
| S855 | QKRKRsFKAVV | PhosphoSitePlus | |
| Dephosphorylation site |
| GRM8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000344173 | R729W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344173 | P259L | COSMIC | Melanoma | 21946352 | ENSP00000344173 | L48* | COSMIC | Melanoma | 21946352 | ENSP00000344173 | I575M | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | I676M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344173 | I574V | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | A808E | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | A128S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344173 | C64W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344173 | M206I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344173 | L76M | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | G465E | COSMIC | Melanoma | 21946352 | ENSP00000344173 | S894F | COSMIC | Melanoma | 21946352 | ENSP00000344173 | E365K | COSMIC | Skin Cancer | 21984974 | ENSP00000344173 | V773D | COSMIC | Melanoma | 21946352 | ENSP00000344173 | E463K | COSMIC | Melanoma | 21946352 | ENSP00000344173 | S691T | COSMIC | Breast Cancer | 20668451 | ENSP00000344173 | V150I | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | S649F | COSMIC | Melanoma | 21946352 | ENSP00000344173 | K669N | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | I629V | COSMIC | Melanoma | 21499247 | ENSP00000344173 | G709R | COSMIC | Skin Cancer | 21984974 | ENSP00000344173 | R619L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000344173 | A282D | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | G523W | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | T118I | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | P643T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000344173 | W215C | COSMIC | Lung Cancer | 20668451 | ENSP00000344173 | G49R | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| GRM8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRM8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GRM8_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GRM8_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GRM8_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GRM8_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04724 | Glutamatergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007601 | visual perception | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007608 | sensory perception of smell | IEA | biological_process |
| GO:0001642 | group III metabotropic glutamate receptor activity | IEA | molecular_function |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0030818 | negative regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008066 | glutamate receptor activity | TAS | molecular_function |