| UniProt/SwissProt ID: | GRB10_HUMAN |
| Description: | growth factor receptor-bound protein 10 [Source:HGNC Symbol;Acc:4564] |
| Location: | chr7 p12.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y9 | SLESLySACSM | FYN | HPRD |
| T155 | SPPVLtPGSLP | PhosphoSitePlus | |
| S372 | RKALLsPFSTP | MAPK1 | HPRD |
| Y67 | SLESLySACSM | FYN | HPRD; RegPhos |
| S150 | LCGPGsPPVLT | Erk2 | RegPhos |
| S476 | ILGSQsPLHPS | Erk2(MAPK1 | RegPhos |
| S476 | ILGSQsPLHPS | MAPK3 | phosphoELM |
| T364 | LSPFStPVRSV | HPRD | |
| Y404 | YGMLLyQNYRI | PhosphoSitePlus; HPRD; phosphoELM | |
| Y9 | SLESLySACSM | SRC | HPRD |
| S92 | LCGPGsPPVLT | MAPK1 | HPRD |
| S474 | MNILGsQSPLH | PhosphoSitePlus | |
| S431 | SVSENsLVAMD | RegPhos | |
| S418 | RKALLsPFSTP | PhosphoSitePlus; phosphoELM | |
| S418 | RKALLsPFSTP | Erk2 | RegPhos |
| T376 | LSPFStPVRSV | HPRD | |
| Y67 | SLESLySACSM | SRC | HPRD; phosphoELM; RegPhos |
| S476 | ILGSQsPLHPS | Erk2 | RegPhos |
| S150 | LCGPGsPPVLT | Erk1(MAPK3 | RegPhos |
| S418 | ILGSQsPLHPS | MAPK1 | HPRD |
| S430 | ILGSQsPLHPS | MAPK1 | HPRD |
| S46 | IQPQVsPRQRV | HPRD | |
| S150 | LCGPGsPPVLT | PhosphoSitePlus; RegPhos | |
| S360 | RKALLsPFSTP | MAPK1 | HPRD |
| S428 | PVRSVsENSLV | BPS | PhosphoSitePlus |
| S104 | IQPQVsPRQRV | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S375 | LLSPFsTPVRS | HPRD | |
| T422 | LSPFStPVRSV | PhosphoSitePlus; HPRD; phosphoELM | |
| S150 | LCGPGsPPVLT | Erk2(MAPK1 | RegPhos |
| T178 | FSEDGtSKVVE | HPRD | |
| S476 | ILGSQsPLHPS | MAPK1 | HPRD; phosphoELM |
| Y67 | SLESLySACSM | PhosphoSitePlus | |
| T120 | FSEDGtSKVVE | HPRD | |
| Y67 | SLESLySACSM | Src | RegPhos |
| Y67 | SLESLySACSM | Fyn | phosphoELM; RegPhos |
| Y346 | YGMLLyQNYRI | HPRD | |
| S421 | LLSPFsTPVRS | HPRD; phosphoELM | |
| S476 | ILGSQsPLHPS | PhosphoSitePlus; phosphoELM | |
| S476 | ILGSQsPLHPS | Erk1(MAPK3 | RegPhos |
| S150 | LCGPGsPPVLT | MAPK1 | HPRD; phosphoELM |
| S418 | RKALLsPFSTP | MAPK1 | HPRD |
| S363 | LLSPFsTPVRS | HPRD | |
| S150 | LCGPGsPPVLT | MAPK3 | phosphoELM |
| Y358 | YGMLLyQNYRI | HPRD | |
| Dephosphorylation site |
| GRB10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000381793 | A119V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000381793 | V486M | COSMIC | Lung Cancer | 20668451 | ENSP00000385544 | Q2R | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000381790 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000381793 | Y252N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385544 | Y246N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385770 | A119V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000385770 | K540E | COSMIC | Lung Cancer | 20668451 | ENSP00000349818 | Y252N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000338543 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000381793 | P30T | COSMIC | Lung Cancer | 20668451 | ENSP00000381793 | A415T | COSMIC | Skin Cancer | 21984974 | ENSP00000385046 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385770 | P30T | COSMIC | Lung Cancer | 20668451 | ENSP00000406716 | Y246N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000381793 | R520H | COSMIC | Ovarian Cancer | 20668451 | ENSP00000381793 | K540E | COSMIC | Lung Cancer | 20668451 | ENSP00000385770 | A415T | COSMIC | Skin Cancer | 21984974 | ENSP00000385366 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385770 | V486M | COSMIC | Lung Cancer | 20668451 | ENSP00000385770 | R520H | COSMIC | Ovarian Cancer | 20668451 | ENSP00000385770 | Y252N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385189 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000385748 | Y194N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000406716 | Q2R | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GRB10_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GRB10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK03_HUMAN | GRB10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | GRB10_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | GRB10_HUMAN | kinase -> substrate | RegPhos |
| SRC_HUMAN | GRB10_HUMAN | kinase -> substrate | HPRD; RegPhos |
| FYN_HUMAN | GRB10_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| GRB10_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008286 | insulin receptor signaling pathway | IEA | biological_process |
| GO:0030949 | positive regulation of vascular endothelial growth | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0042326 | negative regulation of phosphorylation | IEA | biological_process |
| GO:0030178 | negative regulation of Wnt receptor signaling path | IEA | biological_process |
| GO:0042327 | positive regulation of phosphorylation | IEA | biological_process |
| GO:0032868 | response to insulin stimulus | IEA | biological_process |
| GO:0046627 | negative regulation of insulin receptor signaling | IEA | biological_process |
| GO:0046627 | negative regulation of insulin receptor signaling | ISS | biological_process |
| GO:0032868 | response to insulin stimulus | ISS | biological_process |
| GO:0005158 | insulin receptor binding | ISS | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0045719 | negative regulation of glycogen biosynthetic proce | IEA | biological_process |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005070 | SH3/SH2 adaptor activity | IEA | molecular_function |
| GO:0046325 | negative regulation of glucose import | ISS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046325 | negative regulation of glucose import | IEA | biological_process |
| GO:0030178 | negative regulation of Wnt receptor signaling path | IDA | biological_process |
| GO:0048009 | insulin-like growth factor receptor signaling path | IEA | biological_process |
| GO:0005158 | insulin receptor binding | IEA | molecular_function |