Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FHL2_HUMAN
Description:four and a half LIM domains 2 [Source:HGNC Symbol;Acc:3703]
Location:chr2 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y93LCTDCySNEYSLIMPhosphoSitePlus
T175TTGGVtYREQPLIMPhosphoSitePlus
Y236LGGTKyISFEELIMPhosphoSitePlus
S140PIGTKsFIPKDLIMPhosphoSitePlus
Y154FCVPCyEKQHALIMPhosphoSitePlus
T112TIMPGtRKMEYLIMPhosphoSitePlus
Y97CYSNEySSKCQPhosphoSitePlus
Y176TGGVTyREQPWLIMPhosphoSitePlus
T138QQPIGtKSFIPLIMPhosphoSitePlus
T107QECKKtIMPGTLIMPhosphoSitePlus
S238GTKYIsFEERQLIMPhosphoSitePlus
S238GTKYIsFEERQHPRD; phosphoELM
Y27REESPyCVVCFLIMPhosphoSitePlus
T171KKPITtGGVTYHPRD

Dephosphorylation site
FHL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377021D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000386665D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000350846D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000377020D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000322909D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000386633D58VBIOMARTMyeloproliferative Disorders21930507, 21930502
ENSP00000386892D58VBIOMARTMyeloproliferative Disorders21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000350846Gastric CancerMetastasiscell lineDown0.5417022644
ENSP00000350846Lung CancerNormal vs. CancertissueUp15626334
ENSP00000350846Gastric CancerMetastasiscell lineDown0.5417022644

Hyperphosphorylation site
FHL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FHL2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0055014atrial cardiac muscle cell developmentIEAbiological_process
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0031430M bandIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0003713transcription coactivator activityNASmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0009725response to hormone stimulusIMPbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0060347heart trabecula formationIEAbiological_process
GO:0055015ventricular cardiac muscle cell developmentIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function


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